Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0KMJML
ADC Name	HSL156 mAb-DT3C conjugate
Synonyms	HSL156 mAb-DT3C; HSL156 mAb DT3C conjugate Click to Show/Hide
Drug Status	Investigative
Indication	In total 1 Indication(s) Small cell lung cancer [ICD11:2C25] Investigative
	3D MOL	2D MOL
Antibody Name	HSL156		Antibody Info
Antigen Name	Junctional adhesion molecule C (JAM3)		Antigen Info
Payload Name	Diphtheria toxin containing streptococcal protein G (DT3C)		Payload Info
Therapeutic Target	Eukaryotic elongation factor 2 (EEF2)		Target Info
Linker Name	Undisclosed

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	1.9	ug/mL	LU-134-A cells	Lung small cell carcinoma
Half Maximal Inhibitory Concentration (IC50)	15	ug/mL	LU-135 cells	Lung small cell carcinoma
Half Maximal Inhibitory Concentration (IC50)	15	ug/mL	SBC-5 cells	Lung small cell carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.90 ng/mL	Positive JAM3 expression (JAM3 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human small cell cancer cell lines.
In Vitro Model	Lung small cell carcinoma	LU-134-A cells		CVCL_1387
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	15.00 ng/mL	Positive JAM3 expression (JAM3 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human small cell cancer cell lines.
In Vitro Model	Lung small cell carcinoma	LU-135 cells		CVCL_1389
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	15.00 ng/mL	Positive JAM3 expression (JAM3 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human small cell cancer cell lines.
In Vitro Model	Lung small cell carcinoma	SBC-5 cells		CVCL_1679

References

Ref 1	Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma. Exp Cell Res. 2023 May 15;426(2):113570. doi: 10.1016/j.yexcr.2023.113570. Epub 2023 Mar 27.