Antibody Information

General Information of This Antibody

Antibody ID	ANI0CKYEB
Antibody Name	HSL156
Synonyms	Anti-human JAM3 mouse mAb Click to Show/Hide
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG3-kappa
Antigen Name	Junctional adhesion molecule C (JAM3)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

HSL156 mAb-DT3C conjugate [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.90 ng/mL	Positive JAM3 expression (JAM3 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human small cell cancer cell lines.
In Vitro Model	Lung small cell carcinoma	LU-134-A cells		CVCL_1387
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	15.00 ng/mL	Positive JAM3 expression (JAM3 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human small cell cancer cell lines.
In Vitro Model	Lung small cell carcinoma	LU-135 cells		CVCL_1389
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	15.00 ng/mL	Positive JAM3 expression (JAM3 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human small cell cancer cell lines.
In Vitro Model	Lung small cell carcinoma	SBC-5 cells		CVCL_1679

References

Ref 1	Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma. Exp Cell Res. 2023 May 15;426(2):113570. doi: 10.1016/j.yexcr.2023.113570. Epub 2023 Mar 27.

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