Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0JNJQT
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| ADC Name |
EP4471061A1 17c10_MC-Dxd
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| Synonyms |
EP4471061A1 17c10_MC-Dxd
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| Organization |
Emergence Therapeutics AG
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
7.72
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| Antibody Name |
huASCT2 17c10 mAb
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Antibody Info | ||||
| Antigen Name |
Amino acid transporter (ASCT2)
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Antigen Info | ||||
| Payload Name |
DX-8951 derivative (DXd)
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
6-Maleimidocaproic acid
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Linker Info | ||||
| Combination Type |
MC-Dxd
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 5- 2 × 10 -5 ug/mL | Positive ASCT2 expression (ASCT2+++/++) | ||
| Method Description |
Target cells were seeded in triplicates into flat-bottom 384-wells plate (400 cells for HCT116 cells). Cells were incubated for 3 to 4 hours at 37°C before addition of an equivalent volume of 2X concentrated ADC or free drug-linker dose range (see table 1 for details). Cells were then incubated into a live cell imaging instrument (Incucyte®) for 6 to 8 days and their confluency was monitored all along the culture.
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| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 135- 6.9 × 10 -3 g/mL | Positive ASCT2 expression (ASCT2+++/++) | ||
| Method Description |
Target cells were seeded in triplicates into flat-bottom 384-wells plate (400 cells for HCT116 cells). Cells were incubated for 3 to 4 hours at 37°C before addition of an equivalent volume of 2X concentrated ADC or free drug-linker dose range (see table 1 for details). Cells were then incubated into a live cell imaging instrument (Incucyte®) for 6 to 8 days and their confluency was monitored all along the culture.
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| In Vitro Model | Colon adenocarcinoma | WiDr cells | CVCL_2760 | ||