Antigen Information
General Information of This Antigen (ID: TAR0YXJAE)
| Antigen Name | Amino acid transporter (ASCT2) |
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|---|---|---|---|---|---|---|
| Gene Name | ASCT2 |
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| Gene ID | ||||||
| Sequence |
MVADPPKGDPKGFSAAAEPTANGDPVAVPVDHHVPAPGGGCGSPQQVRRCLRANLLVLLT
VLAVLAGVALGLGMSGAGGRHALDPAHLVAFSFPGELLLRLLRMIILPLVVCSLVGGAAS LDPSSLGRLGAWALLFFLVTTLLSSALGVALALVLQPGATAAAINASVGATRAAEATPTK EVLDSFLDLLRNIFPSNLVSAAFRSYSTQWEMKWVDEIQNRTSVKTAGEVEGMNILGLVV FAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPVGILFLVASKIMEMDDVG LLFAVLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGILTPLATAFGTSSSSAT LPLMMKFVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNEKPLDFVKIII ILVTATASSVGAAGIPAGGVLTLAIILEAVSLPVHDLSLILAVDWLVDRFCTVINVEGDA FGAGLLQSYAARAEVKSSVPELLQVKSKTPLAPTEEGNPLLRRCPGPPGDAHTCEKESVM Click to Show/Hide
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| Family | Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
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| Uniprot Entry | ||||||
| KEGG ID | ||||||
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
huASCT2 17c10 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
EP4471061A1 17c10_MC-Dxd
[1]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
6-Maleimidocaproic acid |
|
|
ICT_MC-Dxd (Isotype control)
[1]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
6-Maleimidocaproic acid |
|
|
EP4471061A1 17c10_betaGlu-EXA-2
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ICT_betaGlu-EXA-2
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
EP4471061A1 MC_Dxd
[1]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
6-Maleimidocaproic acid |
|
|
betaGlu-EXA-2
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
Idactamab
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
MEDI7247
|
SG3199 (SC-DR002) |
Human deoxyribonucleic acid (hDNA) |
Mal-PEG8-Val-Ala-PABC |