General Information of This Antigen (ID: TAR0ZFUOH)
Antigen Name
Albumin (ALB)
Gene Name
ALB
Gene ID
213
Sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

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Family
ADP-ribosyl cyclase family
Function
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.

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Uniprot Entry
ALBU_HUMAN
HGNC ID
HGNC:399
KEGG ID
hsa:213
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
Alb-DMBA-SIL-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
DMBA-SIL
Alb-DMBA-SIL-DOX [1]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
DMBA-SIL
Undisclosed
ADC Name Payload Target Linker ADC Info
ONS-3015 [2]
Undisclosed
Undisclosed
Undisclosed
ONS-2010 [3]
Undisclosed
Undisclosed
Undisclosed
ONS-1220 [4]
Undisclosed
Undisclosed
Undisclosed
ONS-1035 [5]
Undisclosed
Undisclosed
Undisclosed
ONS-1030 [6]
Undisclosed
Undisclosed
Undisclosed
ONS-1025 [7]
Undisclosed
Undisclosed
Undisclosed
ONS-1020 [8]
Undisclosed
Undisclosed
Undisclosed
ONS-1015 [9]
Undisclosed
Undisclosed
Undisclosed
ONS-1010 [10]
Undisclosed
Undisclosed
Undisclosed
WO2024107885A1 ADC-1 [11]
diABZI STING
Undisclosed
DBCO-PEG8-glu
References
Ref 1 Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33(8):1474-1484.
Ref 2 Introduction to basic information on ADC drug ONS-3015.
Ref 3 Introduction to basic information on ADC drug ONS-2010.
Ref 4 Introduction to basic information on ADC drug ONS-1220.
Ref 5 Introduction to basic information on ADC drug ONS-1035.
Ref 6 Introduction to basic information on ADC drug ONS-1030.
Ref 7 Introduction to basic information on ADC drug ONS-1025.
Ref 8 Introduction to basic information on ADC drug ONS-1020.
Ref 9 Introduction to basic information on ADC drug ONS-1015.
Ref 10 Introduction to basic information on ADC drug ONS-1010.
Ref 11 Nanobody-drug conjugates and methods of preparing thereof