Antigen Information
General Information of This Antigen (ID: TAR0ZFUOH)
| Antigen Name | Albumin (ALB) |
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|---|---|---|---|---|---|---|
| Gene Name | ALB |
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| Gene ID | ||||||
| Sequence |
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV AASQAALGL Click to Show/Hide
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| Family | ADP-ribosyl cyclase family |
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| Function |
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Alb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Alb-DMBA-SIL-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
DMBA-SIL |
|
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Alb-DMBA-SIL-DOX
[1]
|
Doxorubicin |
DNA topoisomerase 2-alpha (TOP2A) |
DMBA-SIL |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
ONS-3015
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
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ONS-2010
[3]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ONS-1220
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
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ONS-1035
[5]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
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ONS-1030
[6]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ONS-1025
[7]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
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ONS-1020
[8]
|
Undisclosed |
Undisclosed |
Undisclosed |
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ONS-1015
[9]
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Undisclosed |
Undisclosed |
Undisclosed |
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ONS-1010
[10]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
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WO2024107885A1 ADC-1
[11]
|
diABZI STING |
Undisclosed |
DBCO-PEG8-glu |
References
