Antibody Information

General Information of This Antibody
Antibody ID
ANI0SURML
Antibody Name
Alb
Antibody Type
Monoclonal antibody (mAb)
Antigen Name
Albumin (ALB)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Alb-DMBA-SIL-MMAE [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 5 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.76 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Thyroid gland anaplastic carcinoma 8505C cells CVCL_1054
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
2.00 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Mouse colon adenocarcinoma MC-38 cells CVCL_B288
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
7.29 nM
Low FOLR1 expression (FOLR1+)
Method Description
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Acute erythroid leukemia TBP-3743 cancer cells Mus musculus
Experiment 4 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
8.92 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Oral cavity squamous cell carcinoma MOC-L2 cells CVCL_A9X4
Experiment 5 Reporting the Activity Date of This ADC [2]
Efficacy Data Half Maximal Effective Concentration (EC50)
1.40 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-MMAE against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated MMAE is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Skin squamous cell carcinoma A431 cells CVCL_0037
Alb-DMBA-SIL-DOX [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 4 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
21.41 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-DOX against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated DOX is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Acute erythroid leukemia TBP-3743 cancer cells Mus musculus
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
35.57 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-DOX against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated DOX is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Thyroid gland anaplastic carcinoma 8505C cells CVCL_1054
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
52.13 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-DOX against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated DOX is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Mouse colon adenocarcinoma MC-38 cells CVCL_B288
Experiment 4 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
224.40 nM
Method Description
The inhibitory activity of Alb-DMBA-SIL-DOX against cancer cell growth was evaluated in various human cancer cell lines in vitro. Caged and conjugated DOX is selectively cytotoxic and activated by X-ray irradiation.
In Vitro Model Oral cavity squamous cell carcinoma MOC-L2 cells CVCL_A9X4
References
Ref 1 Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33(8):1474-1484.
Ref 2 Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers. Mol Cancer Ther. 2023 Feb 1;22(2):155-167.

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