Antigen Information

General Information of This Antigen
Antigen ID
TAR0GZXLR
Antigen Name
Epithelial cell adhesion molecule (EPCAM)
Gene Name
EPCAM
Gene ID
4072
Synonym
GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Adenocarcinoma-associated antigen;Cell surface glycoprotein Trop-1;Epithelial cell surface antigen;Epithelial glycoprotein;Epithelial glycoprotein 314;KS 1/4 antigen;KSA;Major gastrointestinal tumor-associated protein GA733-2;Tumor-associated calcium signal transducer 1;CD_antigen=CD326
Sequence
MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICS
KLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVN
TAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKF
ITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQL
DLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKA
EIKEMGEMHRELNA

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Family
CTL (choline transporter-like) family
Function
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

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Uniprot Entry
EPCAM_HUMAN
HGNC ID
HGNC:11529
KEGG ID
hsa:4072
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huHEA125-amanitin1
Beta-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-Amanitin1 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 3
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 3 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 4
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 4 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 7
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 7 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 10
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 10 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 11
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 11 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 14
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 14 linker
 [1]
 ADC Info 
huHEA125-alpha-amanitin conjugate 15
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-alpha-amanitin conjugate 15 linker
 [1]
 ADC Info 
huHEA125-amanitin3
Beta-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-Amanitin3 linker
 [1]
 ADC Info 
huHEA125-amanitin4
Beta-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
huHEA125-Amanitin4 linker
 [1]
Oportuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
VB4-845
Pseudomonas exotoxin ETA-252-608
Undisclosed
Undisclosed
Varsetatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Varsetatug masetecan
CAMP59
DNA topoisomerase 1 (TOP1)
L-ala-ala-ala (TAL)
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BA-3181
Undisclosed
Undisclosed
Undisclosed
 [2]
 ADC Info 
Oportuzumab monatox (Eleven Bio)
Undisclosed
Undisclosed
Undisclosed
 [3]
References
Ref 1 Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy.
Ref 2 Introduction to basic information on ADC drug BA 3181.
Ref 3 Introduction to basic information on ADC drug Oportuzumab Monatox(Eleven Bio).