Linker Information
General Information of This Linker
| Linker ID |
LIN0WAWEU
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Divinylpyrimidine-PEG4-Val-Ala-PABC
|
|||||
| Linker Type |
Rigid dual-reactive (thiol) linker; Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C39H57N9O8
|
|||||
| Isosmiles |
C=Cc1cc(C=C)nc(NCCCCc2cn(CCOCCOCCOCCOCC(=O)NC(C(=O)NC(C)C(=O)Nc3ccc(CO)cc3)C(C)C)nn2)n1
|
|||||
| InChI |
InChI=1S/C39H57N9O8/c1-6-31-24-32(7-2)44-39(43-31)40-15-9-8-10-34-25-48(47-46-34)16-17-53-18-19-54-20-21-55-22-23-56-27-35(50)45-36(28(3)4)38(52)41-29(5)37(51)42-33-13-11-30(26-49)12-14-33/h6-7,11-14,24-25,28-29,36,49H,1-2,8-10,15-23,26-27H2,3-5H3,(H,41,52)(H,42,51)(H,45,50)(H,40,43,44)
|
|||||
| InChIKey |
PXGKNSYYIRPCRB-UHFFFAOYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
779.94
|
Polar area
|
212.97
|
||
|
Complexity
|
56
|
xlogp Value
|
2.6318
|
|||
|
Heavy Count
|
56
|
Rot Bonds
|
29
|
|||
|
Hbond acc
|
14
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.