Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FSSAM
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| ADC Name |
EP4495597A2 54E-MMAE
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| Synonyms |
EP4495597A2 54E-MMAE
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| Organization |
ICONIC THERAPEUTICS LLC
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| Drug Status |
Investigative
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| Structure |
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| Antibody Name |
54E
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Antibody Info | ||||
| Antigen Name |
Tissue factor (F3)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.11 nM | Positive TF expression (TF+++/++) | ||
| Method Description |
The TF-specific ADCs were added to A431 cells, with either a 72 h incubation or a 4 h incubation followed by removal of excess ADC and culture for another 68 h. A440cells were lysed in CTG assay reagent after treatment.
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| In Vitro Model | Skin squamous cell carcinoma | A431 cells | CVCL_0037 | ||