Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0JGFSG |
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| Antibody Name | 54E |
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| Organization | ICONIC THERAPEUTICS LLC |
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| Synonyms |
54E
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG |
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| Antigen Name | Tissue factor (F3) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Varible Domain |
QVQLVQSGAEVKKPGASVKVSCKASGYTFANYYMHWVRQAPGQGLEWMGIINPSGGITVY
AQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGSKVAALAFDIWGQGTMVTVS S Click to Show/Hide
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| Heavy Chain CDR 1 |
GYTFANYYMH
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| Heavy Chain CDR 2 |
IINPSGGITVYAQKFQG
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| Heavy Chain CDR 3 |
GGSKVAALAFDI
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| Light Chain Varible Domain |
DIQMTQSPSSLSASVGDRVTITCQASQDISNSLNWYQQKPGKAPKLLIYDASNLETGVPS
RFSGSRSGTDFTFTISSLQPEDIATYYCQQYNFHPLTFGGGTKVEIK Click to Show/Hide
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| Light Chain CDR 1 |
QASQDISNSLN
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| Light Chain CDR 2 |
DASNLET
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| Light Chain CDR 3 |
QQYNFHPLT
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
EP4495597A2 54E-MMAE [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.11 nM
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Positive TF expression (TF+++/++) | ||
| Method Description |
The TF-specific ADCs were added to A431 cells, with either a 72 h incubation or a 4 h incubation followed by removal of excess ADC and culture for another 68 h. A440cells were lysed in CTG assay reagent after treatment.
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| In Vitro Model | Skin squamous cell carcinoma | A431 cells | CVCL_0037 | ||