Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FHIKQ
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| ADC Name |
aZO-ADC-4
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| Synonyms |
AZO-ADC-4
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| Organization |
Beijing Institute of Pharmacology and Toxicology.;Chinese Academy of Medical Sciences & Peking Union Medical College.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.6-4.1
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Solubilizing group-PEG4-Hypoxia sensitive linker-Azobenzene
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.038 nM | High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 0.1 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.1 nM | High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to BT474-HDR cells under 0.1 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 21.32 nM | High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 toBT474-HDR cells under 20 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 42.79 nM | High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 20 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
References