Linker Information
General Information of This Linker
| Linker ID |
LIN0KISOB
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| Linker Name |
Solubilizing group-PEG4-Hypoxia sensitive linker-Azobenzene
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| Linker Type |
Hypoxia sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H44N6O10
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| Isosmiles |
OCC1=CC=C(/N=N/C(C=C2)=CC=C2C(NCCNC(CCOCCOCCOCCOCCNC(CCN3C(C=CC3=O)=O)=O)=O)=O)C=C1
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| InChI |
InChI=1S/C34H44N6O10/c41-25-26-1-5-28(6-2-26)38-39-29-7-3-27(4-8-29)34(46)37-14-13-35-31(43)12-17-47-19-21-49-23-24-50-22-20-48-18-15-36-30(42)11-16-40-32(44)9-10-33(40)45/h1-10,41H,11-25H2,(H,35,43)(H,36,42)(H,37,46)/b39-38+
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| InChIKey |
OFIRLOHDBFPDDZ-YMZYAJTMSA-N
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| Pharmaceutical Properties |
Molecule Weight
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696.758
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Polar area
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206.55
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Complexity
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1354.516761
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xlogp Value
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1.3281
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Heavy Count
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50
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Rot Bonds
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25
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Hbond acc
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12
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
aZO-ADC-4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.038 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 0.1 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.1 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to BT474-HDR cells under 0.1 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
21.32 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 toBT474-HDR cells under 20 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
42.79 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 20 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
References