Antigen Information

General Information of This Antigen

Antigen ID	TAR0MKNCY
Antigen Name	Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Gene Name	CEACAM5
Synonym	CEA; Carcinoembryonic antigen;Meconium antigen 100;CD_antigen=CD66e
Sequence	MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN QSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTI SPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQAN NSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP PDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNL ATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI Click to Show/Hide
Family	CEA family
Function	Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. Click to Show/Hide
Uniprot Entry	CEAM5_HUMAN
HGNC ID	HGNC:1817
KEGG ID	hsa:1048

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Actuximab

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Actuximab-MMAE	Monomethyl auristatin E	Undisclosed	Mc-Val-Cit-PABC	[1]

Anti-CEACAM5 antibody

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	IBI3020	MMAE; TOP1 inhibitor	Microtubule (MT)+DNA topoisomerase 1 (TOP1)	A cleavable linker	[2]

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	B9-MMAE	Monomethyl auristatin E	Undisclosed	Mc-Val-Cit-PABC	[3]

BGA5384

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	BGA2588	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	BGA9962	ADC-C3 Payload	Undisclosed	Linker of ADC2-58	[4]
ADC Info	BGA8357	ADC-C3 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	BGA0084	BGA0084 Payload	Undisclosed	ADC-P1 BGB-C-269 Linker	[4]
ADC Info	BGA7413	ADC-C3 Payload	Undisclosed	BGA7413 Linker	[4]
ADC Info	BGA2490	ADC-C3 Payload	Undisclosed	BGA2490 Linker	[4]
ADC Info	BGA0179	ADC-C3 Payload	Undisclosed	BGA0179 Linker	[4]

CEA.5-G1fhL2

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	tWI857167B IC-12	undisclosed	Undisclosed	Undisclosed	[5]

Hu103

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Hu103-32-2-A (1)	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]
ADC Info	Hu103-32-2-A (2)	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]

Hu47

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Hu47-14-2-A	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]

Hu63

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Hu63-13-2-A (1)	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]
ADC Info	Hu63-13-2-A (2)	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]

Hu67

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Hu67-14-2-A (1)	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]
ADC Info	Hu67-14-2-A (2)	RU2833323C1+Hu63-13-2-A+payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[6]

huIgG1 LALA

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	aCEA5-iduronide-exatecan	Exatecan	Undisclosed	MC-iduronide	[7]
ADC Info	aCEA5-K (Ac)-exatecan	Exatecan	Undisclosed	MC-K (Ac)VC	[7]
ADC Info	aCEA5-AAN-exatecan	Exatecan	Undisclosed	MC-AAN	[7]
ADC Info	aCEA5-iduronide-duocarmycin	Undisclosed	Undisclosed	MC-iduronide	[7]

Labetuzumab

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Labetuzumab govitecan	SN-38	DNA topoisomerase 1 (TOP1)	CL2A
ADC Info	Lmab-CL2A-SN38	Active metabolite of irinotecan SN38	DNA topoisomerase 1 (TOP1)	CL2E	[8]
ADC Info	DTPA-hMN-14-700DX	IRDye 700DX	Undisclosed	Undisclosed	[9]
ADC Info	Labetuzumab-PE40 conjugate	Pseudomonas exotoxin PE40	Eukaryotic elongation factor 2 kinase (EEF2K)	Undisclosed	[10]
ADC Info	Labetuzumab-CL2E-SN-38	Active metabolite of irinotecan SN38	DNA topoisomerase 1 (TOP1)	CL2E	[11]
ADC Info	Labetuzumab-SN-38	Active metabolite of irinotecan SN38	DNA topoisomerase 1 (TOP1)	CL2A	[11]
ADC Info	JP7623413B2 ExampleADC47	Undisclosed	Undisclosed	Undisclosed	[12]

Precemtabart

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Precemtabart tocentecan	Exatecan	DNA topoisomerase 1 (TOP1)	Mal-glucuronide-PABC

Tusamitamab

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Tusamitamab ravtansine	DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
ADC Info	SGN-CEACAM5C	AMDCPT	DNA topoisomerase 1 (TOP1)	A cleavable linker
ADC Info	BGA7650	BGA7650 Payload	Undisclosed	BGA7650 Linker	[4]

undisclosed

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CEA-targeted ISAC	Undisclosed	Undisclosed	Undisclosed	[13]
ADC Info	AU2020291014A1 IC-80	AU2020291014A1-Payload-69	Undisclosed	Aminobenzazepine-linker Formula II-69	[14]
ADC Info	WO2024110905A1 ADC1-2	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC1-2	[4]
ADC Info	WO2024110905A1 ADC1-4	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC1-4	[4]
ADC Info	WO2024110905A1 ADC1-11	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC1-11	[4]
ADC Info	WO2024110905A1 ADC2-2	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC1-2	[4]
ADC Info	WO2024110905A1 ADC2-4	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC1-4	[4]
ADC Info	WO2024110905A1 ADC2-6-2	ADC2-6-2 Payload	Undisclosed	Linker of ADC1-4	[4]
ADC Info	WO2024110905A1 ADC2-7-2	ADC2-6-2 Payload	Undisclosed	Linker of ADC2-7-2	[4]
ADC Info	WO2024110905A1 ADC2-9-1	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC2-9-1	[4]
ADC Info	WO2024110905A1 ADC2-9-2	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC2-9-1	[4]
ADC Info	WO2024110905A1 ADC2-10	Exatecan	Undisclosed	Linker of ADC2-10	[4]
ADC Info	WO2024110905A1 ADC2-11	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC1-11	[4]
ADC Info	WO2024110905A1 ADC2-22	ADC2-22 Payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC2-23	ADC2-23 Payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC2-24	ADC2-24 Payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC2-25	ADC2-25 Payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC2-26	ADC2-26 Payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC2-27	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-27	[4]
ADC Info	WO2024110905A1 ADC2-29	ADC2-29 Payload	Undisclosed	Linker of ADC2-29	[4]
ADC Info	WO2024110905A1 ADC2-30	ADC2-29 Payload	Undisclosed	Linker of ADC2-30	[4]
ADC Info	WO2024110905A1 ADC2-31	ADC2-29 Payload	Undisclosed	Linker of ADC2-31	[4]
ADC Info	WO2024110905A1 ADC2-32	ADC2-29 Payload	Undisclosed	Linker of ADC2-32	[4]
ADC Info	WO2024110905A1 ADC2-33	ADC2-29 Payload	Undisclosed	Linker of ADC2-33	[4]
ADC Info	WO2024110905A1 ADC2-34	ADC2-29 Payload	Undisclosed	Linker of ADC2-34	[4]
ADC Info	WO2024110905A1 ADC2-35	ADC2-29 Payload	Undisclosed	Linker of ADC2-35	[4]
ADC Info	WO2024110905A1 ADC2-36-1	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC2-36-1	[4]
ADC Info	WO2024110905A1 ADC2-36-2	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC2-36-1	[4]
ADC Info	WO2024110905A1 ADC2-37	ADC2-37 Payload	Undisclosed	Linker of ADC2-37	[4]
ADC Info	WO2024110905A1 ADC2-38	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-38	[4]
ADC Info	WO2024110905A1 ADC2-39	ADC2-29 Payload	Undisclosed	Linker of ADC2-39	[4]
ADC Info	WO2024110905A1 ADC2-40	ADC2-29 Payload	Undisclosed	Linker of ADC2-40	[4]
ADC Info	WO2024110905A1 ADC2-41	ADC2-29 Payload	Undisclosed	Linker of ADC2-41	[4]
ADC Info	WO2024110905A1 ADC2-42	ADC2-29 Payload	Undisclosed	Linker of ADC2-42	[4]
ADC Info	WO2024110905A1 ADC2-42-RO	ADC2-29 Payload	Undisclosed	Linker of ADC2-42	[4]
ADC Info	WO2024110905A1 ADC2-43	Monomethyl auristatin E	Microtubule (MT)	Linker of ADC2-43	[4]
ADC Info	WO2024110905A1 ADC2-44	ADC2-23 Payload	Undisclosed	Linker of ADC2-44	[4]
ADC Info	WO2024110905A1 ADC2-45	ADC2-45 Payload	Undisclosed	Linker of ADC2-44	[4]
ADC Info	WO2024110905A1 ADC2-46	ADC2-23 Payload	Undisclosed	Linker of ADC2-46	[4]
ADC Info	WO2024110905A1 ADC2-47	ADC2-45 Payload	Undisclosed	Linker of ADC2-47	[4]
ADC Info	WO2024110905A1 ADC2-48	ADC2-48 Payload	Undisclosed	Linker of ADC2-48	[4]
ADC Info	WO2024110905A1 ADC2-49	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-49	[4]
ADC Info	WO2024110905A1 ADC2-50	ADC2-29 Payload	Undisclosed	Linker of ADC2-50	[4]
ADC Info	WO2024110905A1 ADC2-51	ADC2-29 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC2-53	ADC2-29 Payload	Undisclosed	Linker of ADC2-53	[4]
ADC Info	WO2024110905A1 ADC2-54	ADC2-29 Payload	Undisclosed	Linker of ADC2-54	[4]
ADC Info	WO2024110905A1 ADC2-55	ADC2-45 Payload	Undisclosed	Linker of ADC2-30	[4]
ADC Info	WO2024110905A1 ADC2-56	ADC2-56 Payload	Undisclosed	Linker of ADC2-56	[4]
ADC Info	WO2024110905A1 ADC2-57	ADC2-29 Payload	Undisclosed	Linker of ADC2-57	[4]
ADC Info	WO2024110905A1 ADC2-58	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-58	[4]
ADC Info	WO2024110905A1 ADC2-59	ADC2-45 Payload	Undisclosed	Linker of ADC2-57	[4]
ADC Info	WO2024110905A1 ADC2-60	ADC2-29 Payload	Undisclosed	Linker of ADC2-60	[4]
ADC Info	WO2024110905A1 ADC2-61	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-61	[4]
ADC Info	WO2024110905A1 ADC2-62-1	Monomethyl auristatin E	Microtubule (MT)	ADC2-62-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-62-2	Monomethyl auristatin E	Microtubule (MT)	ADC2-62-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-63-1	Monomethyl auristatin E	Microtubule (MT)	ADC2-63-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-63-2	Monomethyl auristatin E	Microtubule (MT)	ADC2-63-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-64-1	Monomethyl auristatin E	Microtubule (MT)	ADC2-64-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-64-2	Monomethyl auristatin E	Microtubule (MT)	ADC2-64-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-65-1	Monomethyl auristatin E	Microtubule (MT)	ADC2-62-1 Linker	[4]
ADC Info	WO2024110905A1 ADC2-65-2	Monomethyl auristatin E	Microtubule (MT)	ADC2-64-1 Linker	[4]
ADC Info	WO2024110905A1 ADC3-1	ADC2-29 Payload	Undisclosed	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC3-2	ADC2-29 Payload	Undisclosed	Linker of ADC2-30	[4]
ADC Info	WO2024110905A1 ADC3-3	ADC2-29 Payload	Undisclosed	Linker of ADC2-32	[4]
ADC Info	WO2024110905A1 ADC3-4	ADC2-29 Payload	Undisclosed	Linker of ADC2-40	[4]
ADC Info	WO2024110905A1 ADC3-5	ADC2-45 Payload	Undisclosed	Linker of ADC2-44	[4]
ADC Info	WO2024110905A1 ADC3-6	ADC2-48 Payload	Undisclosed	Linker of ADC2-48	[4]
ADC Info	WO2024110905A1 ADC3-7	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-49	[4]
ADC Info	WO2024110905A1 ADC3-8	ADC2-29 Payload	Undisclosed	Linker of ADC2-50	[4]
ADC Info	WO2024110905A1 ADC3-9	ADC2-29 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC3-10	ADC2-45 Payload	Undisclosed	Linker of ADC2-30	[4]
ADC Info	WO2024110905A1 ADC3-11	ADC2-29 Payload	Undisclosed	Linker of ADC2-57	[4]
ADC Info	WO2024110905A1 ADC3-12	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-58	[4]
ADC Info	WO2024110905A1 ADC3-13	ADC2-45 Payload	Undisclosed	Linker of ADC2-57	[4]
ADC Info	WO2024110905A1 ADC3-14	ADC2-29 Payload	Undisclosed	Linker of ADC2-60	[4]
ADC Info	WO2024110905A1 ADC3-15	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC2-61	[4]
ADC Info	WO2024110905A1 ADC3-16	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC3-16	[4]
ADC Info	WO2024110905A1 ADC3-17	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Linker of ADC3-16	[4]
ADC Info	WO2024110905A1 ADC3-18	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Val-Ala	[4]
ADC Info	WO2024110905A1 ADC3-19	ADC3-19 Payload	Undisclosed	Linker of ADC3-19	[4]
ADC Info	WO2024110905A1 ADC3-20	ADC2-29 Payload	Undisclosed	Linker of ADC3-20	[4]
ADC Info	WO2024110905A1 ADC-C2	ADC2-29 Payload	Undisclosed	ADCC2-Linker	[4]
ADC Info	WO2024110905A1 ADC-C3	ADC-C3 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-C4	ADC-C4 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-C5	ADC-C4 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-P1 BGB-C-269	ADC2-29 Payload	Undisclosed	ADC-P1 BGB-C-269 Linker	[4]
ADC Info	WO2024110905A1 ADC-P2 BGB-C-276	ADC-C3 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-P3 BGB-C-290	ADC-P3 BGB-C-290 Payload	Undisclosed	ADC-P1 BGB-C-269 Linker	[4]
ADC Info	WO2024110905A1 ADC-1 BGB-C-81	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly	[4]
ADC Info	WO2024110905A1 ADC-2 BGB-C-115	ADC2-29 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-3 BGB-C-245	ADC2-29 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-4 BGB-C-318	ADC2-29 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-5 BGB-C-277	ADC-5 BGB-C-277 Payload	Undisclosed	ADC-5 BGB-C-277 Linker	[4]
ADC Info	WO2024110905A1 ADC-6 BGB-C-306	ADC-6 BGB-C-306 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-7 BGB-C-329	ADC-7 BGB-C-329 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-8 BGB-C-323	ADC-8 BGB-C-323 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-9 BGB-C-331	ADC-9 BGB-C-331 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-10 BGB-C-325	ADC-10 BGB-C-325 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-11 BGB-C-307	ADC-11 BGB-C-307 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-12 BGB-C-287	ADC-12 BGB-C-287 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-13 BGB-C-288	ADC-13 BGB-C-288 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-14 BGB-C-317	ADC-14 BGB-C-317 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-15 BGB-C-292	ADC-15 BGB-C-292 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-16 BGB-C-348	ADC-16 BGB-C-348 Payload	Undisclosed	ADC-16 BGB-C-348 Linker	[4]
ADC Info	WO2024110905A1 ADC-17 BGB-C-319	ADC-17 BGB-C-319 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-18 BGB-C-343	ADC-18 BGB-C-343 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-19 BGB-C-302	ADC-19 BGB-C-302 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-20 BGB-C-320	ADC-20 BGB-C-320 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-21 BGB-C-330	ADC-21 BGB-C-330 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-22 BGB-C-346	ADC-22 BGB-C-346 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-23 BGB-C-358	ADC-23 BGB-C-358 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-24 BGB-C-373	ADC-24 BGB-C-373 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-25 BGB-C-421	ADC-25 BGB-C-421 Payload	Undisclosed	Linker of ADC2-51	[4]
ADC Info	WO2024110905A1 ADC-26 BGB-C-395	ADC-26 BGB-C-395 Payload	Undisclosed	ADC-26 BGB-C-395 Linker	[4]

References

Ref 1	A high-affinity antibody-drug conjugates Actuximab-MMAE for potent and selective targeting of CEACAM5-Positive tumors
Ref 2	Innovent Biologics announced that the world's first CEACAM5 dual-payload ADC (IBI3020) has completed the first patient administration in its Phase I clinical study
Ref 3	A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Ref 4	Anti-CEA antibody drug conjugates and methods of use
Ref 5	Thienobenzodiazepine immunoconjugates and uses thereof
Ref 6	Conjugate of anti-CEA antibody and exatecan analog and pharmaceutical uses thereof
Ref 7	Generation and Characterization of Iduronidase-Cleavable ADCs
Ref 8	Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34.
Ref 9	Carcinoembryonic antigen-targeted photodynamic therapy in colorectal cancer models. EJNMMI Res. 2019 Dec 11;9(1):108. doi: 10.1186/s13550-019-0580-z.
Ref 10	Introduction to basic information on ADC drug Labetuzumab-PE40 conjugate; 27 Oct 2020.
Ref 11	Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 12	Antibody-drug complexes containing hemiasterlin derivatives
Ref 13	A highly efficacious next-generation CEACAM5 (CEA)-targeted Boltbody™ ISAC for the treatment of colorectal, pancreatic and lung tumors
Ref 14	Aminobenzazepine compounds, immunoconjugates, and uses thereof

Antigen Information

Citation

Visitor Map

Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xiaowu DONG (dongxw@zju.edu.cn)

Prof. Luo FANG (fangluo@zjcc.org.cn)