Antigen Information

General Information of This Antigen (ID: TAR0MKNCY)
Antigen Name
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Gene Name
CEACAM5
Gene ID
1048
Synonym
CEA; Carcinoembryonic antigen;Meconium antigen 100;CD66e
Sequence
MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ
HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY
TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV
NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP
TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ
AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN
QSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTI
SPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQAN
NSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS
LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP
PDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNL
ATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI

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Family
CEA family
Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.

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Uniprot Entry
CEAM5_HUMAN
HGNC ID
HGNC:1817
KEGG ID
hsa:1048
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Actuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Actuximab-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CEA antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BG-C477 [2]
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
BMS-986490
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-CEA mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BL-M09D1
Ed-04
DNA topoisomerase 1 (TOP1)
Gly-Mal-Gly-Gly-Phe-Gly
 ADC Info 
Anti-CEACAM5 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IBI3020 [3]
MMAE; TOP1 inhibitor
Microtubule (MT)+DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
B9-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
BGA2588 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
BGA9962 [5]
ADC-C3 Payload
Undisclosed
Linker of ADC2-58
 ADC Info 
BGA8357 [5]
ADC-C3 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
BGA0084 [5]
BGA0084 Payload
Undisclosed
ADC-P1 BGB-C-269 Linker
 ADC Info 
BGA7413 [5]
ADC-C3 Payload
Undisclosed
BGA7413 Linker
 ADC Info 
BGA2490 [5]
ADC-C3 Payload
Undisclosed
BGA2490 Linker
 ADC Info 
BGA0179 [5]
ADC-C3 Payload
Undisclosed
BGA0179 Linker
 ADC Info 
CEA.5-G1fhL2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TWI857167B IC-12 [6]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu103-32-2-A (1) [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Hu103-32-2-A (2) [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu47-14-2-A [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu63-13-2-A (1) [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Hu63-13-2-A (2) [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu67-14-2-A (1) [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Hu67-14-2-A (2) [7]
RU2833323C1+Hu63-13-2-A+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
huIgG1 LALA
 Antibody Info 
ADC Name Payload Target Linker ADC Info
aCEA5-iduronide-exatecan [8]
Exatecan
DNA topoisomerase 1 (TOP1)
MC-iduronide
 ADC Info 
aCEA5-K (Ac)-exatecan [8]
Exatecan
DNA topoisomerase 1 (TOP1)
MC-K (Ac)VC
 ADC Info 
aCEA5-AAN-exatecan [8]
Exatecan
DNA topoisomerase 1 (TOP1)
MC-AAN
 ADC Info 
aCEA5-iduronide-duocarmycin [8]
Undisclosed
Undisclosed
MC-iduronide
 ADC Info 
Labetuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Labetuzumab govitecan
SN-38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Lmab-CL2A-SN38 [9]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
 ADC Info 
DTPA-hMN-14-700DX [10]
IRDye 700DX
Undisclosed
Undisclosed
 ADC Info 
Labetuzumab-PE40 conjugate [11]
Pseudomonas exotoxin PE40
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Labetuzumab-CL2E-SN-38 [12]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
 ADC Info 
Labetuzumab-SN-38 [12]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
JP7623413B2 ExampleADC47 [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Precemtabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Precemtabart tocentecan
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-glucuronide-PABC
 ADC Info 
Tusamitamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tusamitamab ravtansine
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
SGN-CEACAM5C
AMDCPT
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
BGA7650 [5]
BGA7650 Payload
Undisclosed
BGA7650 Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CEA-targeted ISAC [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AU2020291014A1 IC-80 [15]
AU2020291014A1-Payload-69
Undisclosed
Aminobenzazepine-linker Formula II-69
 ADC Info 
WO2024110905A1 ADC1-2 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC1-2
 ADC Info 
WO2024110905A1 ADC1-4 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC1-4
 ADC Info 
WO2024110905A1 ADC1-11 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC1-11
 ADC Info 
WO2024110905A1 ADC2-2 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC1-2
 ADC Info 
WO2024110905A1 ADC2-4 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC1-4
 ADC Info 
WO2024110905A1 ADC2-6-2 [5]
ADC2-6-2 Payload
Undisclosed
Linker of ADC1-4
 ADC Info 
WO2024110905A1 ADC2-7-2 [5]
ADC2-6-2 Payload
Undisclosed
Linker of ADC2-7-2
 ADC Info 
WO2024110905A1 ADC2-9-1 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC2-9-1
 ADC Info 
WO2024110905A1 ADC2-9-2 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC2-9-1
 ADC Info 
WO2024110905A1 ADC2-10 [5]
Exatecan
DNA topoisomerase 1 (TOP1)
Linker of ADC2-10
 ADC Info 
WO2024110905A1 ADC2-11 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC1-11
 ADC Info 
WO2024110905A1 ADC2-22 [5]
ADC2-22 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC2-23 [5]
ADC2-23 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC2-24 [5]
ADC2-24 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC2-25 [5]
ADC2-25 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC2-26 [5]
ADC2-26 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC2-27 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-27
 ADC Info 
WO2024110905A1 ADC2-29 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-29
 ADC Info 
WO2024110905A1 ADC2-30 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-30
 ADC Info 
WO2024110905A1 ADC2-31 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-31
 ADC Info 
WO2024110905A1 ADC2-32 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-32
 ADC Info 
WO2024110905A1 ADC2-33 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-33
 ADC Info 
WO2024110905A1 ADC2-34 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-34
 ADC Info 
WO2024110905A1 ADC2-35 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-35
 ADC Info 
WO2024110905A1 ADC2-36-1 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC2-36-1
 ADC Info 
WO2024110905A1 ADC2-36-2 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC2-36-1
 ADC Info 
WO2024110905A1 ADC2-37 [5]
ADC2-37 Payload
Undisclosed
Linker of ADC2-37
 ADC Info 
WO2024110905A1 ADC2-38 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-38
 ADC Info 
WO2024110905A1 ADC2-39 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-39
 ADC Info 
WO2024110905A1 ADC2-40 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-40
 ADC Info 
WO2024110905A1 ADC2-41 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-41
 ADC Info 
WO2024110905A1 ADC2-42 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-42
 ADC Info 
WO2024110905A1 ADC2-42-RO [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-42
 ADC Info 
WO2024110905A1 ADC2-43 [5]
Monomethyl auristatin E
Microtubule (MT)
Linker of ADC2-43
 ADC Info 
WO2024110905A1 ADC2-44 [5]
ADC2-23 Payload
Undisclosed
Linker of ADC2-44
 ADC Info 
WO2024110905A1 ADC2-45 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-44
 ADC Info 
WO2024110905A1 ADC2-46 [5]
ADC2-23 Payload
Undisclosed
Linker of ADC2-46
 ADC Info 
WO2024110905A1 ADC2-47 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-47
 ADC Info 
WO2024110905A1 ADC2-48 [5]
ADC2-48 Payload
Undisclosed
Linker of ADC2-48
 ADC Info 
WO2024110905A1 ADC2-49 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-49
 ADC Info 
WO2024110905A1 ADC2-50 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-50
 ADC Info 
WO2024110905A1 ADC2-51 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC2-53 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-53
 ADC Info 
WO2024110905A1 ADC2-54 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-54
 ADC Info 
WO2024110905A1 ADC2-55 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-30
 ADC Info 
WO2024110905A1 ADC2-56 [5]
ADC2-56 Payload
Undisclosed
Linker of ADC2-56
 ADC Info 
WO2024110905A1 ADC2-57 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-57
 ADC Info 
WO2024110905A1 ADC2-58 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-58
 ADC Info 
WO2024110905A1 ADC2-59 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-57
 ADC Info 
WO2024110905A1 ADC2-60 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-60
 ADC Info 
WO2024110905A1 ADC2-61 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-61
 ADC Info 
WO2024110905A1 ADC2-62-1 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-62-1 Linker
 ADC Info 
WO2024110905A1 ADC2-62-2 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-62-1 Linker
 ADC Info 
WO2024110905A1 ADC2-63-1 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-63-1 Linker
 ADC Info 
WO2024110905A1 ADC2-63-2 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-63-1 Linker
 ADC Info 
WO2024110905A1 ADC2-64-1 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-64-1 Linker
 ADC Info 
WO2024110905A1 ADC2-64-2 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-64-1 Linker
 ADC Info 
WO2024110905A1 ADC2-65-1 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-62-1 Linker
 ADC Info 
WO2024110905A1 ADC2-65-2 [5]
Monomethyl auristatin E
Microtubule (MT)
ADC2-64-1 Linker
 ADC Info 
WO2024110905A1 ADC3-1 [5]
ADC2-29 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC3-2 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-30
 ADC Info 
WO2024110905A1 ADC3-3 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-32
 ADC Info 
WO2024110905A1 ADC3-4 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-40
 ADC Info 
WO2024110905A1 ADC3-5 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-44
 ADC Info 
WO2024110905A1 ADC3-6 [5]
ADC2-48 Payload
Undisclosed
Linker of ADC2-48
 ADC Info 
WO2024110905A1 ADC3-7 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-49
 ADC Info 
WO2024110905A1 ADC3-8 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-50
 ADC Info 
WO2024110905A1 ADC3-9 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC3-10 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-30
 ADC Info 
WO2024110905A1 ADC3-11 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-57
 ADC Info 
WO2024110905A1 ADC3-12 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-58
 ADC Info 
WO2024110905A1 ADC3-13 [5]
ADC2-45 Payload
Undisclosed
Linker of ADC2-57
 ADC Info 
WO2024110905A1 ADC3-14 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-60
 ADC Info 
WO2024110905A1 ADC3-15 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC2-61
 ADC Info 
WO2024110905A1 ADC3-16 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC3-16
 ADC Info 
WO2024110905A1 ADC3-17 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Linker of ADC3-16
 ADC Info 
WO2024110905A1 ADC3-18 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Val-Ala
 ADC Info 
WO2024110905A1 ADC3-19 [5]
ADC3-19 Payload
Undisclosed
Linker of ADC3-19
 ADC Info 
WO2024110905A1 ADC3-20 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC3-20
 ADC Info 
WO2024110905A1 ADC-C2 [5]
ADC2-29 Payload
Undisclosed
ADCC2-Linker
 ADC Info 
WO2024110905A1 ADC-C3 [5]
ADC-C3 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-C4 [5]
ADC-C4 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-C5 [5]
ADC-C4 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-P1 BGB-C-269 [5]
ADC2-29 Payload
Undisclosed
ADC-P1 BGB-C-269 Linker
 ADC Info 
WO2024110905A1 ADC-P2 BGB-C-276 [5]
ADC-C3 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-P3 BGB-C-290 [5]
ADC-P3 BGB-C-290 Payload
Undisclosed
ADC-P1 BGB-C-269 Linker
 ADC Info 
WO2024110905A1 ADC-1 BGB-C-81 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024110905A1 ADC-2 BGB-C-115 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-3 BGB-C-245 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-4 BGB-C-318 [5]
ADC2-29 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-5 BGB-C-277 [5]
ADC-5 BGB-C-277 Payload
Undisclosed
ADC-5 BGB-C-277 Linker
 ADC Info 
WO2024110905A1 ADC-6 BGB-C-306 [5]
ADC-6 BGB-C-306 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-7 BGB-C-329 [5]
ADC-7 BGB-C-329 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-8 BGB-C-323 [5]
ADC-8 BGB-C-323 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-9 BGB-C-331 [5]
ADC-9 BGB-C-331 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-10 BGB-C-325 [5]
ADC-10 BGB-C-325 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-11 BGB-C-307 [5]
ADC-11 BGB-C-307 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-12 BGB-C-287 [5]
ADC-12 BGB-C-287 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-13 BGB-C-288 [5]
ADC-13 BGB-C-288 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-14 BGB-C-317 [5]
ADC-14 BGB-C-317 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-15 BGB-C-292 [5]
ADC-15 BGB-C-292 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-16 BGB-C-348 [5]
ADC-16 BGB-C-348 Payload
Undisclosed
ADC-16 BGB-C-348 Linker
 ADC Info 
WO2024110905A1 ADC-17 BGB-C-319 [5]
ADC-17 BGB-C-319 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-18 BGB-C-343 [5]
ADC-18 BGB-C-343 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-19 BGB-C-302 [5]
ADC-19 BGB-C-302 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-20 BGB-C-320 [5]
ADC-20 BGB-C-320 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-21 BGB-C-330 [5]
ADC-21 BGB-C-330 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-22 BGB-C-346 [5]
ADC-22 BGB-C-346 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-23 BGB-C-358 [5]
ADC-23 BGB-C-358 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-24 BGB-C-373 [5]
ADC-24 BGB-C-373 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-25 BGB-C-421 [5]
ADC-25 BGB-C-421 Payload
Undisclosed
Linker of ADC2-51
 ADC Info 
WO2024110905A1 ADC-26 BGB-C-395 [5]
ADC-26 BGB-C-395 Payload
Undisclosed
ADC-26 BGB-C-395 Linker
 ADC Info 
References
Ref 1 A high-affinity antibody-drug conjugates Actuximab-MMAE for potent and selective targeting of CEACAM5-Positive tumors
Ref 2 BG-C477, a novel topoisomerase 1 inhibitor-based ADC, exhibits antitumor activity in carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)-expressing preclinical models
Ref 3 Innovent Biologics announced that the world's first CEACAM5 dual-payload ADC (IBI3020) has completed the first patient administration in its Phase I clinical study
Ref 4 A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Ref 5 Anti-CEA antibody drug conjugates and methods of use
Ref 6 Thienobenzodiazepine immunoconjugates and uses thereof
Ref 7 Conjugate of anti-CEA antibody and exatecan analog and pharmaceutical uses thereof
Ref 8 Generation and Characterization of Iduronidase-Cleavable ADCs
Ref 9 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34.
Ref 10 Carcinoembryonic antigen-targeted photodynamic therapy in colorectal cancer models. EJNMMI Res. 2019 Dec 11;9(1):108. doi: 10.1186/s13550-019-0580-z.
Ref 11 Introduction to basic information on ADC drug Labetuzumab-PE40 conjugate; 27 Oct 2020.
Ref 12 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 13 Antibody-drug complexes containing hemiasterlin derivatives
Ref 14 A highly efficacious next-generation CEACAM5 (CEA)-targeted Boltbody™ ISAC for the treatment of colorectal, pancreatic and lung tumors
Ref 15 Aminobenzazepine compounds, immunoconjugates, and uses thereof