Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0ALLLF
ADC Name
SAR-445953
Synonyms
SAR445953; SAR445953; SAR445953; PF-08046050; PF 08046050; PF08046050; SGN-CEACAM5C; SGN CEACAM5C
   Click to Show/Hide
Organization
Sanofi
Drug Status
Phase 1
Indication
In total 5 Indication(s)
Colorectal cancer
Phase 1
Clinical Trial
Gastric cancer
Phase 1
Clinical Trial
Lung cancer
Phase 1
Clinical Trial
Oesophageal cancer
Phase 1
Clinical Trial
Pancreatic cancer
Phase 1
Clinical Trial
Drug-to-Antibody Ratio
8
Antibody Name
Tusamitamab
  Antibody Info 
Antigen Name
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
  Antigen Info 
Payload Name
7-aminomethyl-10,11-methylenedioxycamptothecin (AMDCPT)
  Payload Info 
Therapeutic Target
DNA topoisomerase 1 (TOP1)
  Target Info 
Linker Name
Undisclosed
Conjugate Type
Undisclosed