Antigen Information

General Information of This Antigen (ID: TAR0KVKEF)
Antigen Name
HLA class II histocompatibility antigen gamma chain (CD74)
Gene Name
CD74
Gene ID
972
Synonym
DHLAG; HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;CD74
Sequence
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLL
LAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPM
GALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLP
LQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

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Function
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

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Uniprot Entry
HG2A_HUMAN
HGNC ID
HGNC:1697
KEGG ID
hsa:972
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD74 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
S227928
S64315 (MIK665)
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Val-Cit-(PEG24) linker
 ADC Info 
Anti-hCD74 clone11
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD74 ADC 12-13 [1]
Anti-CD74 ADC 12-13 payload
Undisclosed
Anti-CD74 ADC 12-13 linker
 ADC Info 
Anti-CD74 ADC 12-14 [1]
Anti-CD74 ADC 12-14 payload
Undisclosed
Anti-CD74 ADC 12-14 linker
 ADC Info 
Anti-CD74 ADC 12-15 [1]
Anti-CD74 ADC 12-15 payload
Undisclosed
Anti-CD74 ADC 12-15 linker
 ADC Info 
Anti-hCD74 LL1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD74 ADC 12-4 [1]
Anti-CD74 ADC 12-4 payload
Undisclosed
Anti-CD74 ADC 12-4 linker
 ADC Info 
Anti-CD74 ADC 2-7 [1]
Anti-CD74 ADC 2-7 payload
Undisclosed
Anti-CD74 ADC 2-7 linker
 ADC Info 
Anti-CD74 ADC 3-4 [1]
Anti-CD74 ADC 3-4 payload
Undisclosed
Anti-CD74 ADC 3-4 linker
 ADC Info 
Anti-CD74 ADC 4-3 [1]
Anti-CD74 ADC 4-3 payload
Undisclosed
Anti-CD74 ADC 4-3 linker
 ADC Info 
Anti-CD74 ADC 5-3 [1]
Anti-CD74 ADC 5-3 payload
Undisclosed
Anti-CD74 ADC 5-3 linker
 ADC Info 
Anti-CD74 ADC 6-2 [1]
Anti-CD74 ADC 6-2 payload
Undisclosed
Anti-CD74 ADC 6-2 linker
 ADC Info 
Anti-CD74 ADC 7-1 [1]
Anti-CD74 ADC 7-1 payload
Undisclosed
Anti-CD74 ADC 7-1 linker
 ADC Info 
Anti-CD74 ADC 8-5 [1]
Anti-CD74 ADC 8-5 payload
Undisclosed
Anti-CD74 ADC 8-5 linker
 ADC Info 
Anti-CD74 ADC 9-4 [1]
Anti-CD74 ADC 9-4 payload
Undisclosed
Anti-CD74 ADC 9-4 linker
 ADC Info 
Anti-CD74 ADC 10-1 [1]
Anti-CD74 ADC 10-1 payload
Undisclosed
Anti-CD74 ADC 10-1 linker
 ADC Info 
Anti-CD74 ADC 11-5 [1]
Anti-CD74 ADC 11-5 payload
Undisclosed
Anti-CD74 ADC 11-5 linker
 ADC Info 
Anti-CD74 ADC 12-3 [1]
Anti-CD74 ADC 12-3 payload
Undisclosed
Anti-CD74 ADC 12-3 linker
 ADC Info 
Anti-CD74 ADC 13-7 [1]
Anti-CD74 ADC 13-7 payload
Undisclosed
Anti-CD74 ADC 13-7 linker
 ADC Info 
Anti-CD74 ADC 14-5 [1]
Anti-CD74 ADC 14-5 payload
Undisclosed
Anti-CD74 ADC 14-5 linker
 ADC Info 
Anti-CD74 ADC 15-5 [1]
Anti-CD74 ADC 15-5 payload
Undisclosed
Anti-CD74 ADC 15-5 linker
 ADC Info 
Anti-CD74 ADC 16-5 [1]
Anti-CD74 ADC 16-5 payload
Undisclosed
Anti-CD74 ADC 16-5 linker
 ADC Info 
Anti-CD74 ADC 17-2 [1]
Anti-CD74 ADC 17-2 payload
Undisclosed
Anti-CD74 ADC 17-2 linker
 ADC Info 
Bezetabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Bezetabart debotansine
SC347
Microtubule (MT)
Cys-12 ADC linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD74 Milatuzumab DANAPAE152C S375C-P1-L35-P1 [2]
P1 payload
Undisclosed
L35 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L12-P4 [2]
P4 payload
Undisclosed
L12 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L12-P3 [2]
P3 payload
Undisclosed
L12 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P2-L13-P1 [2]
P1 payload
Undisclosed
L13 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L32-P2 [2]
P2 payload
Undisclosed
L32 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L30-P2 [2]
P2 payload
Undisclosed
L30 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L17-P2 [2]
P2 payload
Undisclosed
L17 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L27-P1 [2]
P1 payload
Undisclosed
L27 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L11-P1 [2]
P1 payload
Undisclosed
L11 linker
 ADC Info 
CD74 Milatuzumab DANAPAE152C S375C-P1-L18-P2 [2]
P2 payload
Undisclosed
L18 linker
 ADC Info 
HuMab-CD74-005
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMab-CD74-005-vcMMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
HuMab-CD74-005-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
HuMab-CD74-006
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMab-CD74-006-vcMMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
HuMab-CD74-006-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
HuMab-CD74-011
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMab-CD74-011-vcMMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Milatuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Milatuzumab doxorubicin
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
SMCC-hydrazide
 ADC Info 
Milatuzumab-RSL3-NH2 [4]
RSL3-NH2
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
Mal-PEG4-DBCO-Ala-Val
 ADC Info 
HLL1-CL2A-SN38 [5]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Antibody-drug conjugate (Ambrx Inc) [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody drug conjugate for anti-inflammatory applications; 2017-04-13.
Ref 2 Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
Ref 3 Antibodies, expression vectors, recombinant prokaryotic host cells, pharmaceutical compositions, and uses of the antibody
Ref 4 The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead. Eur J Med Chem. 2022 Dec 15;244:114863.
Ref 5 Optimal cleavable linker for antibody-SN-38 conjugates for cancer therapy: Impact of linker's stability on efficacy. Cancer Res (2012) 72 (8_Supplement): 2526.
Ref 6 Introduction to basic information on ADC drug Antibody-drug conjugate (Ambrx Inc)