Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ZQDBC
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| ADC Name |
Anti-CD74 ADC 12-14
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| Synonyms |
Anti-CD74-ADC 12-14
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| Organization |
Merck & Co., Inc.
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| Drug Status |
Investigative
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| Indication |
In total 3 Indication(s)
Diffuse large B-cell lymphoma [ICD11:2A81]
Investigative
Renal cell carcinoma [ICD11:2C90]
Investigative
Sezary syndrome [ICD11:2B02]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Anti-hCD74 clone11
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Antibody Info | ||||
| Antigen Name |
HLA class II histocompatibility antigen gamma chain (CD74)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
Anti-CD74 ADC 12-14 linker
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| Conjugate Type |
The drug linker was conjugated to the unnatural amino acid (UAA) para-azido phenylalanine (p-AF)
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 4.45 ug/mL | Negative CD74 expression (CD74 -) | ||
| Method Description |
Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls 12-11, 12-12, and naked anti-hCD74 (LL1) control were assessed in HUT-78 an SUDHL-6 cells as well as 786-O cells.
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| In Vitro Model | Renal cell carcinoma | 786-O cells | CVCL_1051 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 23.00 ng/mL | Positive CD74 expression (CD74 +++/++) | ||
| Method Description |
Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls 12-11, 12-12, and naked anti-hCD74 (LL1) control were assessed in HUT-78 an SUDHL-6 cells as well as 786-O cells.
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| In Vitro Model | Diffuse large B-cell lymphoma | SU-DHL-6 cells | CVCL_2206 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 55.00 ng/mL | Positive CD74 expression (CD74 +++/++) | ||
| Method Description |
Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls 12-11, 12-12, and naked anti-hCD74 (LL1) control were assessed in HUT-78 an SUDHL-6 cells as well as 786-O cells.
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| In Vitro Model | T lymphocytic leukemia | HuT 78 cells | CVCL_0337 | ||
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