Antigen Information

General Information of This Antigen (ID: TAR0DEDPZ)
Antigen Name
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Gene Name
TNFRSF1A
Gene ID
7132
Synonym
TNFAR; TNFR1; Tumor necrosis factor receptor 1;Tumor necrosis factor receptor type I;p55;p60;CD120a
Sequence
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR

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Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

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Uniprot Entry
TNR1A_HUMAN
HGNC ID
HGNC:11916
KEGG ID
hsa:7132
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-TNF mAb 8c11
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2022171101A1 ADC-47 [1]
WO2022171101A1 ADC-47 payload
Undisclosed
WO2022171101A1 ADC-47 linker
 ADC Info 
WO2022171101A1 ADC-49 [1]
WO2022171101A1 ADC-49 payload
Undisclosed
WO2022171101A1 ADC-49 linker
 ADC Info 
WO2023025248A1 ADC-50 [2]
WO2023025248A1 ADC-50 payload
Undisclosed
WO2023025248A1 ADC-50 linker
 ADC Info 
WO2023025248A1 ADC-51 [2]
WO2023025248A1 ADC-51 payload
Undisclosed
WO2023025248A1 ADC-51 linker
 ADC Info 
WO2023025248A1 ADC-52 [2]
WO2023025248A1 ADC-52 payload
Undisclosed
WO2023025248A1 ADC-52 linker
 ADC Info 
WO2023025248A1 ADC-53 [2]
WO2023025248A1 ADC-53 payload
Undisclosed
WO2023025248A1 ADC-53 linker
 ADC Info 
WO2023025248A1 ADC-54 [2]
WO2023025248A1 ADC-54 payload
Undisclosed
WO2023025248A1 ADC-54 linker
 ADC Info 
WO2023025248A1 ADC-55 [2]
WO2023025248A1 ADC-55 payload
Undisclosed
WO2023025248A1 ADC-55 linker
 ADC Info 
Anti-TNF mAb alpha-TNF
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-TNF ADC 121 [3]
GRM cpd 17
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 126 [3]
GRM cpd 20
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 127 [3]
GRM cpd 25
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 128 [3]
GRM cpd 26
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 129 [3]
GRM cpd 30
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 131 [3]
GRM cpd 31
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 134 [3]
GRM cpd 64
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 104 [3]
GRM cpd 5
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 105 [3]
GRM cpd 16
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 106 [3]
GRM cpd 17
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 107 [3]
GRM cpd 18
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 108 [3]
GRM cpd 19
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 109 [3]
GRM cpd 20
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 110 [3]
GRM cpd 22
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 111 [3]
GRM cpd 23
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 112 [3]
GRM cpd 24
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 113 [3]
GRM cpd 25
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 114 [3]
GRM cpd 26
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 115 [3]
GRM cpd 30
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 116 [3]
GRM cpd 31
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 117 [3]
GRM cpd 33
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 118 [3]
GRM cpd 61
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 119 [3]
GRM cpd 5
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 120 [3]
GRM cpd 5
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 123 [3]
GRM cpd 19
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 124 [3]
GRM cpd 19
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 125 [3]
GRM cpd 20
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 130 [3]
GRM cpd 31
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 132 [3]
GRM cpd 32
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 133 [3]
GRM cpd 32
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF ADC 135 [3]
GRM cpd 63
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-TNF mAb B-II-B059
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2022171101A1 ADC-46 [1]
WO2022171101A1 ADC-46 payload
Undisclosed
WO2022171101A1 ADC-46 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2023025248A1 ADC-58 [2]
WO2023025248A1 ADC-58 payload
Undisclosed
WO2023025248A1 ADC-58 linker
 ADC Info 
WO2023025248A1 ADC-59 [2]
WO2023025248A1 ADC-59 payload
Undisclosed
WO2023025248A1 ADC-59 linker
 ADC Info 
WO2023025248A1 ADC-60 [2]
WO2023025248A1 ADC-60 payload
Undisclosed
WO2023025248A1 ADC-60 linker
 ADC Info 
WO2022135332A1 1-12 [4]
WO2022135332A1_1-12 payload
Undisclosed
WO2022135332A1_1-12 linker
 ADC Info 
Iscalimab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2023025248A1 ADC-57 [2]
WO2023025248A1 ADC-57 payload
Undisclosed
WO2023025248A1 ADC-57 linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DB-2306 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Steroid conjugate; 2022-08-18.
Ref 2 Steroid compound and conjugate thereof; 2023-03-02.
Ref 3 Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.
Ref 4 Steroid conjugate; 2022-06-30.
Ref 5 DB-2306, a Novel Anti-TNFalpha Monoclonal Antibody Drug Conjugate, Is a Promising Novel Therapeutic Approach for Autoimmune Disease. Arthritis Rheumatol. 2022; 74 (suppl 9).