Antigen Information

General Information of This Antigen
Antigen ID
TAR0DEDPZ
Antigen Name
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Gene Name
TNFRSF1A
Gene ID
7132
Synonym
TNFAR; TNFR1; Tumor necrosis factor receptor 1;Tumor necrosis factor receptor type I;p55;p60;CD_antigen=CD120a
Sequence
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR

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Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

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Uniprot Entry
TNR1A_HUMAN
HGNC ID
HGNC:11916
KEGG ID
hsa:7132
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-TNF mAb 8c11
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2022171101A1 ADC-47
WO2022171101A1 ADC-47 payload
Undisclosed
WO2022171101A1 ADC-47 linker
 [1]
 ADC Info 
WO2022171101A1 ADC-49
WO2022171101A1 ADC-49 payload
Undisclosed
WO2022171101A1 ADC-49 linker
 [1]
 ADC Info 
WO2023025248A1 ADC-50
WO2023025248A1 ADC-50 payload
Undisclosed
WO2023025248A1 ADC-50 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-51
WO2023025248A1 ADC-51 payload
Undisclosed
WO2023025248A1 ADC-51 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-52
WO2023025248A1 ADC-52 payload
Undisclosed
WO2023025248A1 ADC-52 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-53
WO2023025248A1 ADC-53 payload
Undisclosed
WO2023025248A1 ADC-53 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-54
WO2023025248A1 ADC-54 payload
Undisclosed
WO2023025248A1 ADC-54 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-55
WO2023025248A1 ADC-55 payload
Undisclosed
WO2023025248A1 ADC-55 linker
 [2]
Anti-TNF mAb alpha-TNF
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-TNF ADC 121
GRM cpd 17
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 126
GRM cpd 20
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 127
GRM cpd 25
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 128
GRM cpd 26
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 129
GRM cpd 30
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 131
GRM cpd 31
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 134
GRM cpd 64
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 104
GRM cpd 5
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 105
GRM cpd 16
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 106
GRM cpd 17
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 107
GRM cpd 18
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 108
GRM cpd 19
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 109
GRM cpd 20
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 110
GRM cpd 22
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 111
GRM cpd 23
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 112
GRM cpd 24
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 113
GRM cpd 25
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 114
GRM cpd 26
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 115
GRM cpd 30
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 116
GRM cpd 31
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 117
GRM cpd 33
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 118
GRM cpd 61
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 119
GRM cpd 5
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 120
GRM cpd 5
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 123
GRM cpd 19
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 124
GRM cpd 19
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 125
GRM cpd 20
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 130
GRM cpd 31
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 132
GRM cpd 32
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 133
GRM cpd 32
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
 ADC Info 
Anti-TNF ADC 135
GRM cpd 63
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 [3]
Anti-TNF mAb B-II-B059
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2022171101A1 ADC-46
WO2022171101A1 ADC-46 payload
Undisclosed
WO2022171101A1 ADC-46 linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2023025248A1 ADC-58
WO2023025248A1 ADC-58 payload
Undisclosed
WO2023025248A1 ADC-58 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-59
WO2023025248A1 ADC-59 payload
Undisclosed
WO2023025248A1 ADC-59 linker
 [2]
 ADC Info 
WO2023025248A1 ADC-60
WO2023025248A1 ADC-60 payload
Undisclosed
WO2023025248A1 ADC-60 linker
 [2]
 ADC Info 
WO2022135332A1 1-12
WO2022135332A1_1-12 payload
Undisclosed
WO2022135332A1_1-12 linker
 [4]
Iscalimab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2023025248A1 ADC-57
WO2023025248A1 ADC-57 payload
Undisclosed
WO2023025248A1 ADC-57 linker
 [2]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DB-2306
Undisclosed
Undisclosed
Undisclosed
 [5]
References
Ref 1 Steroid conjugate; 2022-08-18.
Ref 2 Steroid compound and conjugate thereof; 2023-03-02.
Ref 3 Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. J Med Chem. 2022 Dec 8;65(23):15893-15934.
Ref 4 Steroid conjugate; 2022-06-30.
Ref 5 DB-2306, a Novel Anti-TNFalpha Monoclonal Antibody Drug Conjugate, Is a Promising Novel Therapeutic Approach for Autoimmune Disease. Arthritis Rheumatol. 2022; 74 (suppl 9).