General Information of This Antigen
Antigen ID
TAR0BKUOF
Antigen Name
B-lymphocyte antigen CD20 (MS4A1)
Gene Name
MS4A1
Gene ID
931
Synonym
CD20; B-lymphocyte surface antigen B1;Bp35;Leukocyte surface antigen Leu-16;Membrane-spanning 4-domains subfamily A member 1;CD_antigen=CD20
Sequence
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP

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Family
MHC class II family
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

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Uniprot Entry
CD20_HUMAN
HGNC ID
HGNC:7315
KEGG ID
hsa:931
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
CD20-A Anti-ody
ADC Info ADC Name Payload Target Linker Ref
CD20-A Antibody-Compound (X)
CD20-A Antibody-Compound (X) payload
Undisclosed
CD20-A Antibody-Compound (X) linker
[1]
CD20-A Antibody-Compound (XI)
CD20-A Antibody-Compound (XI) payload
Undisclosed
CD20-A Antibody-Compound (XI) linker
[1]
CD20-A Antibody-Compound (XIV)
CD20-A Antibody-Compound (XIV) payload
Undisclosed
CD20-A Antibody-Compound (XIV) linker
[1]
CD20-A Antibody-Compound (XVIII)
CD20-A Antibody-Compound (XVIII) payload
Undisclosed
CD20-A Antibody-Compound (XVIII) linker
[1]
CD20-A Antibody-Compound (Ie)
CD20-A Antibody-Compound (Ie) payload
Undisclosed
CD20-A Antibody-Compound (Ie) linker
[1]
CD20-A Antibody-Compound (XIX)
CD20-A Antibody-Compound (XIX) payload
Undisclosed
CD20-A Antibody-Compound (XIX) linker
[1]
CD20-A Antibody-Compound (Ii)
CD20-A Antibody-Compound (Ii) payload
Undisclosed
CD20-A Antibody-Compound (Ii) linker
[1]
CD20-A Antibody-Compound (XLI)
CD20-A Antibody-Compound (XLI) payload
Undisclosed
CD20-A Antibody-Compound (XLI) linker
[1]
CD20-A Antibody-Compound (XVI)
CD20-A Antibody-Compound (XIX) payload
Undisclosed
CD20-A Antibody-Compound (XIX) linker
[1]
CD20-A Antibody-Compound (XL)
CD20-A Antibody-Compound (XL) payload
Undisclosed
CD20-A Antibody-Compound (XL) linker
[1]
CD20-A Antibody-Compound (XLII)
CD20-A Antibody-Compound (XLII) payload
Undisclosed
CD20-A Antibody-Compound (XLII) linker
[1]
CD20-A Antibody-Compound (XV)
CD20-A Antibody-Compound (XV) payload
Undisclosed
CD20-A Antibody-Compound (XV) linker
[1]
CD20-A Antibody-Compound (XLIII)
CD20-A Antibody-Compound (XLIII) payload
Undisclosed
CD20-A Antibody-Compound (XLIII) linker
[1]
Chimeric Anti-CD20 mAb
ADC Info ADC Name Payload Target Linker Ref
MRG-001
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[2]
Ibritumomab
ADC Info ADC Name Payload Target Linker Ref
Ibritumomab-Compound 9
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 9 linker
[3]
Ibritumomab-Compound 17
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 17 linker
[3]
Ibritumomab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 25 linker
[3]
Ibritumomab-Compound 31
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 31 linker
[3]
Ibritumomab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 36 linker
[3]
Ibritumomab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 43 linker
[3]
Ibritumomab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 49 linker
[3]
Ibritumomab-Compound 55
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 55 linker
[3]
Ibritumomab-Compound 59
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 59 linker
[3]
Ibritumomab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 64 linker
[3]
Ibritumomab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 69 linker
[3]
Ibritumomab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 74 linker
[3]
Ibritumomab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 75 linker
[3]
Ibritumomab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 76 linker
[3]
Ibritumomab-Compound 77
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 77 linker
[3]
Ibritumomab-Compound 78
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 78 linker
[3]
Ibritumomab-Compound 79
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 79 linker
[3]
Ibritumomab-Compound 80
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 80 linker
[3]
Ofatumumab
ADC Info ADC Name Payload Target Linker Ref
Ofatumumab-Compound 9
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 9 linker
[3]
Ofatumumab-Compound 17
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 17 linker
[3]
Ofatumumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 25 linker
[3]
Ofatumumab-Compound 31
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 31 linker
[3]
Ofatumumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 36 linker
[3]
Ofatumumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 43 linker
[3]
Ofatumumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 49 linker
[3]
Ofatumumab-Compound 55
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 55 linker
[3]
Ofatumumab-Compound 59
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 59 linker
[3]
Ofatumumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 64 linker
[3]
Ofatumumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 69 linker
[3]
Ofatumumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 74 linker
[3]
Ofatumumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 75 linker
[3]
Ofatumumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 76 linker
[3]
Ofatumumab-Compound 77
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 77 linker
[3]
Ofatumumab-Compound 78
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 78 linker
[3]
Ofatumumab-Compound 79
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 79 linker
[3]
Ofatumumab-Compound 80
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 80 linker
[3]
Rituximab
ADC Info ADC Name Payload Target Linker Ref
Rituximab-Compound (la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (la) linker
[4]
Rituximab-Compound (lc)
NeoDegrader P4
Protein cereblon (CRBN)
Rituximab-Compound (lc) linker
[4]
Rituximab-Compound (le)
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (le) linker
[4]
Rituximab-Compound (lf)
NeoDegrader P6
Protein cereblon (CRBN)
Rituximab-Compound (lf) linker
[4]
Rituximab-Compound (lg)
NeoDegrader P2
Protein cereblon (CRBN)
Rituximab-Compound (lg) linker
[4]
Rituximab-Compound (lh)
NeoDegrader P13
Protein cereblon (CRBN)
Rituximab-Compound (lh) linker
[4]
Rituximab-Compound (li)
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (li) linker
[4]
Rituximab-Compound (lk)
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (lk) linker
[4]
Rituximab-Compound (ll)
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (ll) linker
[4]
Rituximab-Compound (lm)
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (lm) linker
[4]
Rituximab-Compound (la) DAR 4
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (la) linker
[4]
WO2017089895A1 ADC70
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC70 linker
[5]
WO2017089895A1 ADC71
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC71 linker
[5]
WO2017089895A1 ADC72
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC72 linker
[5]
Rituximab-Compound (X)
Rituximab-Compound (X) payload
Undisclosed
Rituximab-Compound (X) linker
[1]
Rituximab-Compound (XI)
Rituximab-Compound (XI) payload
Undisclosed
Rituximab-Compound (XI) linker
[1]
Rituximab-Compound (XIV)
Rituximab-Compound (XIV) payload
Undisclosed
Rituximab-Compound (XIV) linker
[1]
Rituximab-Compound (XVIII)
Rituximab-Compound (XVIII) payload
Undisclosed
Rituximab-Compound (XVIII) linker
[1]
Rituximab-Compound (Ie)
Rituximab-Compound (Ie) payload
Undisclosed
Rituximab-Compound (Ie) linker
[1]
Rituximab-Compound (XIX)
Rituximab-Compound (XIX) payload
Undisclosed
Rituximab-Compound (XIX) linker
[1]
Rituximab-Compound (Ii)
Rituximab-Compound (Ii) payload
Undisclosed
Rituximab-Compound (Ii) linker
[1]
Rituximab-Compound (XLI)
Rituximab-Compound (XLI) payload
Undisclosed
Rituximab-Compound (XLI) linker
[1]
Rituximab-Compound (XVI)
Rituximab-Compound (XIX) payload
Undisclosed
Rituximab-Compound (XIX) linker
[1]
Rituximab-Compound (XL)
Rituximab-Compound (XL) payload
Undisclosed
Rituximab-Compound (XL) linker
[1]
Rituximab-Compound (XLII)
Rituximab-Compound (XLII) payload
Undisclosed
Rituximab-Compound (XLII) linker
[1]
Rituximab-Compound (XV)
Rituximab-Compound (XV) payload
Undisclosed
Rituximab-Compound (XV) linker
[1]
EDC-9
Undisclosed
Undisclosed
Undisclosed
[6]
Rituximab-DNA conjugate
DNA mimics
Human Deoxyribonucleic acid (hDNA)
Undisclosed
[7]
Rituximab-Compound (lj)
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (lj) linker
[4]
Rituximab-Compound (XLIII)
Rituximab-Compound (XLIII) payload
Undisclosed
Rituximab-Compound (XLIII) linker
[1]
WO2017089890A1 ADC70
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC70 linker
[8]
WO2017089890A1 ADC71
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC71 linker
[8]
WO2017089890A1 ADC72
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC72 linker
[8]
Rituximab-Compound 9
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 9 linker
[3]
Rituximab-Compound 17
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 17 linker
[3]
Rituximab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 25 linker
[3]
Rituximab-Compound 31
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 31 linker
[3]
Rituximab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 36 linker
[3]
Rituximab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 43 linker
[3]
Rituximab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 49 linker
[3]
Rituximab-Compound 55
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 55 linker
[3]
Rituximab-Compound 59
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 59 linker
[3]
Rituximab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 64 linker
[3]
Rituximab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 69 linker
[3]
Rituximab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 74 linker
[3]
Rituximab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 75 linker
[3]
Rituximab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 76 linker
[3]
Rituximab-Compound 77
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 77 linker
[3]
Rituximab-Compound 78
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 78 linker
[3]
Rituximab-Compound 79
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 79 linker
[3]
Rituximab-Compound 80
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 80 linker
[3]
CN109310885B ADC-7
CN109310885B ADC-7 payload
Undisclosed
CN109310885B ADC-7 linker
[9]
CN109310885B ADC-8
CN109310885B ADC-8 payload
Undisclosed
CN109310885B ADC-8 linker
[9]
Tositumomab
ADC Info ADC Name Payload Target Linker Ref
Tositumomab-Compound 9
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 9 linker
[3]
Tositumomab-Compound 17
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 17 linker
[3]
Tositumomab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 25 linker
[3]
Tositumomab-Compound 31
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 31 linker
[3]
Tositumomab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 36 linker
[3]
Tositumomab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 43 linker
[3]
Tositumomab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 49 linker
[3]
Tositumomab-Compound 55
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 55 linker
[3]
Tositumomab-Compound 59
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 59 linker
[3]
Tositumomab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 64 linker
[3]
Tositumomab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 69 linker
[3]
Tositumomab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 74 linker
[3]
Tositumomab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 75 linker
[3]
Tositumomab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 76 linker
[3]
Tositumomab-Compound 77
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 77 linker
[3]
Tositumomab-Compound 78
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 78 linker
[3]
Tositumomab-Compound 79
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 79 linker
[3]
Tositumomab-Compound 80
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 80 linker
[3]
Veltuzumab
ADC Info ADC Name Payload Target Linker Ref
Veltuzumab-SN-38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[10]
Veltuzumab-CL2E-SN-38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
[10]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
CON-4619
Undisclosed
Undisclosed
Undisclosed
[11]
TRS-005
Undisclosed
Undisclosed
Undisclosed
[12]
APEC-1
Undisclosed
Undisclosed
Undisclosed
[13]
B-1452
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[14]
Tissue/Disease specific Abundances of This Antigen
Tissue specific Abundances of This Antigen
ICD Disease Classification 01
Click to Show/Hide the 1 Disease of This Class
Bacterial infection [ICD-11: 1A00-1C4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.40E-12; Fold-change: 1.216703593; Z-score: 1.315769335
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 02
Click to Show/Hide the 22 Disease of This Class
Brain cancer [ICD-11: 2A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Brainstem
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.712709155; Fold-change: 0.014223714; Z-score: 0.176213606
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.822410822; Fold-change: -0.127909132; Z-score: -0.85850914
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem
The Specific Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.017084588; Fold-change: -0.47626011; Z-score: -0.997662838
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Nervous
The Specific Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001365585; Fold-change: 0.052722889; Z-score: 0.113746929
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic myeloid leukemia [ICD-11: 2A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.91E-22; Fold-change: -1.739907356; Z-score: -2.950512191
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Whole blood
The Specific Disease Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000353647; Fold-change: -3.014152593; Z-score: -5.740869331
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
MyeloDysplastic syndromes [ICD-11: 2A37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 3.30E-05; Fold-change: -0.441996334; Z-score: -1.010247845
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.03525625; Fold-change: -2.318015384; Z-score: -1.834018106
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lymphoma [ICD-11: 2A90- 2A85]
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Differential expression pattern of antigen in diseases
The Studied Tissue Tonsil
The Specific Disease Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.723884372; Fold-change: 0.218856769; Z-score: 0.293414319
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Gastric cancer [ICD-11: 2B72]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric
The Specific Disease Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.150148092; Fold-change: -1.883888996; Z-score: -1.663341262
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000803619; Fold-change: -1.788783853; Z-score: -1.181988183
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Colon cancer [ICD-11: 2B90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon
The Specific Disease Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.58E-20; Fold-change: -1.380161265; Z-score: -0.86077679
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.07E-11; Fold-change: -0.850297489; Z-score: -0.576412537
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pancreatic cancer [ICD-11: 2C10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pancreas
The Specific Disease Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.567307243; Fold-change: 0.074793973; Z-score: 0.034427405
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.383767432; Fold-change: 0.206647516; Z-score: 0.089392326
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver cancer [ICD-11: 2C12]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.100022711; Fold-change: -0.084884064; Z-score: -0.331477504
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000185179; Fold-change: -0.31548436; Z-score: -0.639808613
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.923256193; Fold-change: -0.145737636; Z-score: -0.463161902
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lung cancer [ICD-11: 2C25]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.04E-13; Fold-change: 0.834017441; Z-score: 0.698157434
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.02E-11; Fold-change: 0.691989723; Z-score: 0.709787757
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Melanoma [ICD-11: 2C30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.86E-06; Fold-change: 0.777750607; Z-score: 1.029113437
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sarcoma [ICD-11: 2C35]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 5.52E-07; Fold-change: 0.019590703; Z-score: 0.088036495
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.655020462; Fold-change: -0.168424499; Z-score: -8.291447933
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Breast cancer [ICD-11: 2C60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Breast
The Specific Disease Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.00E-41; Fold-change: 0.185942743; Z-score: 0.385775823
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.015524495; Fold-change: 0.11415017; Z-score: 0.121297024
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ovarian cancer [ICD-11: 2C73]
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Differential expression pattern of antigen in diseases
The Studied Tissue Ovarian
The Specific Disease Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.49662401; Fold-change: -0.199009328; Z-score: -0.428283765
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.402248565; Fold-change: -0.336051074; Z-score: -0.95759095
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cervical cancer [ICD-11: 2C77]
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Differential expression pattern of antigen in diseases
The Studied Tissue Cervical
The Specific Disease Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.320974831; Fold-change: -0.013257905; Z-score: -0.052967459
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Uterine cancer [ICD-11: 2C78]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.007921513; Fold-change: -0.053430793; Z-score: -0.129231948
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.00056827; Fold-change: 0.57938241; Z-score: 2.328043681
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Prostate cancer [ICD-11: 2C82]
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Differential expression pattern of antigen in diseases
The Studied Tissue Prostate
The Specific Disease Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.174064176; Fold-change: -0.515081306; Z-score: -0.316445778
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Bladder cancer [ICD-11: 2C94]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.381522523; Fold-change: 0.352947233; Z-score: 0.297186786
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Retina cancer [ICD-11: 2D02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Uvea
The Specific Disease Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.10009362; Fold-change: 0.075716129; Z-score: 1.220239244
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thyroid cancer [ICD-11: 2D10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Thyroid
The Specific Disease Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.327599854; Fold-change: 0.198760936; Z-score: 0.083906233
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.387521481; Fold-change: 0.229327102; Z-score: 0.119121831
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Adrenal cancer [ICD-11: 2D11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adrenal cortex
The Specific Disease Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.685543789; Fold-change: -0.050099287; Z-score: -0.653392594
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Head and neck cancer [ICD-11: 2D42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Head and neck
The Specific Disease Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.086758129; Fold-change: 1.089617172; Z-score: 0.460446436
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pituitary cancer [ICD-11: 2F37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pituitary
The Specific Disease Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.716803812; Fold-change: 0.078806956; Z-score: 0.253300043
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Pituitary
The Specific Disease Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.945031508; Fold-change: -0.056284717; Z-score: -0.162242802
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 03
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Thrombocytopenia [ICD-11: 3B64]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.84968763; Fold-change: -1.565595288; Z-score: -0.65010836
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 04
Click to Show/Hide the 2 Disease of This Class
Lupus erythematosus [ICD-11: 4A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.002919926; Fold-change: -0.364713632; Z-score: -0.278840746
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autoimmune disease [ICD-11: 4A4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral monocyte
The Specific Disease Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.874495557; Fold-change: -0.050686514; Z-score: -0.162454579
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 05
Click to Show/Hide the 1 Disease of This Class
Hyperlipoproteinaemia [ICD-11: 5C80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.17E-08; Fold-change: -3.900590421; Z-score: -2.318447457
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 06
Click to Show/Hide the 1 Disease of This Class
Schizophrenia [ICD-11: 6A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Superior temporal cortex
The Specific Disease Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.888022229; Fold-change: 0.041585535; Z-score: 0.243334723
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 08
Click to Show/Hide the 3 Disease of This Class
Multiple sclerosis [ICD-11: 8A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Spinal cord
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.483171961; Fold-change: 0.152805595; Z-score: 1.269780411
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Plasmacytoid dendritic cells
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.998229558; Fold-change: 0.195171828; Z-score: 0.213417357
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Epilepsy [ICD-11: 8A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peritumoral cortex
The Specific Disease Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.194365942; Fold-change: 0.258016057; Z-score: 1.753972755
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cerebral ischaemic stroke [ICD-11: 8B11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.13E-06; Fold-change: -0.561445736; Z-score: -1.073179795
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.662845608; Fold-change: -0.169886965; Z-score: -0.138758177
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 1
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HIV [ICD-11: 1C60-1C62]
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Differential expression pattern of antigen in diseases
The Studied Tissue White matter
The Specific Disease HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.155963909; Fold-change: -0.038867531; Z-score: -0.15657478
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Influenza [ICD-11: 1E30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.070422778; Fold-change: 1.515304039; Z-score: 2.194182361
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic hepatitis C [ICD-11: 1E51.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.986061067; Fold-change: 0.424587373; Z-score: 0.388819303
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sepsis [ICD-11: 1G40-1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.20E-11; Fold-change: -1.52660992; Z-score: -1.103806894
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Septic shock [ICD-11: 1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.18E-46; Fold-change: -1.652337489; Z-score: -1.559057456
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pediatric respiratory syncytial virus infection [ICD-11: CA40.11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.018485145; Fold-change: -0.538012342; Z-score: -0.859171363
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 11
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Essential hypertension [ICD-11: BA00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.324851468; Fold-change: -0.964710772; Z-score: -2.448370949
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myocardial infarction [ICD-11: BA41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.392639083; Fold-change: 0.036453804; Z-score: 0.044623166
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Coronary artery disease [ICD-11: BA8Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.338053662; Fold-change: -0.637083142; Z-score: -0.289391484
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aortic stenosis [ICD-11: BB70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Calcified aortic valve
The Specific Disease Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.260901571; Fold-change: 0.005583445; Z-score: 0.013131282
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arteriosclerosis [ICD-11: BD40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.579529783; Fold-change: -0.071022014; Z-score: -0.084298549
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aneurysm [ICD-11: BD50]
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Differential expression pattern of antigen in diseases
The Studied Tissue Intracranial artery
The Specific Disease Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.246351834; Fold-change: 0.058436213; Z-score: 0.275770923
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 12
Click to Show/Hide the 8 Disease of This Class
Immunodeficiency [ICD-11: 4A00-4A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.57708459; Fold-change: 0.071540765; Z-score: 0.101704429
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Apnea [ICD-11: 7A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Hyperplastic tonsil
The Specific Disease Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.163221069; Fold-change: 2.129959948; Z-score: 5.681434118
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Olive pollen allergy [ICD-11: CA08.00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.138529937; Fold-change: -0.301923311; Z-score: -0.924848792
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic rhinosinusitis [ICD-11: CA0A]
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Differential expression pattern of antigen in diseases
The Studied Tissue Sinus mucosa
The Specific Disease Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.078675406; Fold-change: 0.296771962; Z-score: 1.462548221
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic obstructive pulmonary disease [ICD-11: CA22]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.328506396; Fold-change: 0.171395182; Z-score: 0.18421621
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Small airway epithelium
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000254771; Fold-change: -0.085037678; Z-score: -0.19905966
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Asthma [ICD-11: CA23]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal and bronchial airway
The Specific Disease Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.067728183; Fold-change: 0.120697949; Z-score: 0.165505128
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Human rhinovirus infection [ICD-11: CA42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal Epithelium
The Specific Disease Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.708045884; Fold-change: -0.022514188; Z-score: -0.032269094
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001880484; Fold-change: 0.886657418; Z-score: 1.808683076
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 13
Click to Show/Hide the 5 Disease of This Class
Periodontal disease [ICD-11: DA0C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 5.65E-10; Fold-change: 1.200841496; Z-score: 1.304531564
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Eosinophilic gastritis [ICD-11: DA42.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric antrum
The Specific Disease Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.990850078; Fold-change: -0.401264683; Z-score: -0.712102154
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver failure [ICD-11: DB99.7-DB99.8]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 7.70E-06; Fold-change: 1.187958151; Z-score: 4.112338896
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ulcerative colitis [ICD-11: DD71]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon mucosal
The Specific Disease Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 6.43E-05; Fold-change: 0.984825161; Z-score: 1.510808647
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Irritable bowel syndrome [ICD-11: DD91.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.20647983; Fold-change: 0.06534649; Z-score: 0.03776449
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 14
Click to Show/Hide the 5 Disease of This Class
Atopic dermatitis [ICD-11: EA80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.024017273; Fold-change: 0.071105654; Z-score: 0.242243799
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Psoriasis [ICD-11: EA90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.509860208; Fold-change: -0.040565887; Z-score: -0.14132477
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.83E-25; Fold-change: 0.515283293; Z-score: 1.816391091
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Vitiligo [ICD-11: ED63.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.126794592; Fold-change: -0.277605939; Z-score: -0.855940764
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alopecia [ICD-11: ED70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin from scalp
The Specific Disease Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.018010037; Fold-change: 0.209085793; Z-score: 0.311698275
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sensitive skin [ICD-11: EK0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.798636167; Fold-change: -0.038415224; Z-score: -0.098363703
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 15
Click to Show/Hide the 6 Disease of This Class
Osteoarthritis [ICD-11: FA00-FA0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.829929867; Fold-change: -0.013392292; Z-score: -0.054126081
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthropathy [ICD-11: FA00-FA5Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.698703934; Fold-change: -0.223322055; Z-score: -0.345748833
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.951197645; Fold-change: 0.07688488; Z-score: 0.138641118
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rheumatoid arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.040029292; Fold-change: 0.248758908; Z-score: 0.563360764
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ankylosing spondylitis [ICD-11: FA92.0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pheripheral blood
The Specific Disease Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.167020645; Fold-change: -0.240931448; Z-score: -0.31494915
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Osteoporosis [ICD-11: FB83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.206937392; Fold-change: 0.131361242; Z-score: 1.133907868
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 16
Click to Show/Hide the 2 Disease of This Class
Endometriosis [ICD-11: GA10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.1869272; Fold-change: 0.323647971; Z-score: 0.977957202
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Interstitial cystitis [ICD-11: GC00.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.002282485; Fold-change: 3.969808494; Z-score: 2.590161081
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 19
Click to Show/Hide the 1 Disease of This Class
Preterm birth [ICD-11: KA21.4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Myometrium
The Specific Disease Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.125888508; Fold-change: -0.167777774; Z-score: -0.723463666
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 2
Click to Show/Hide the 8 Disease of This Class
Acute myelocytic leukemia [ICD-11: 2A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.06E-30; Fold-change: -1.950320686; Z-score: -1.269513458
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myeloma [ICD-11: 2A83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.044451567; Fold-change: -0.728719237; Z-score: -1.54010728
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.153986639; Fold-change: 0.032626533; Z-score: 0.204607179
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Oral cancer [ICD-11: 2B6E]
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Differential expression pattern of antigen in diseases
The Studied Tissue Oral
The Specific Disease Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.925035726; Fold-change: 0.075312087; Z-score: 0.052763329
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.320103572; Fold-change: -0.083168066; Z-score: -0.084817123
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Esophagal cancer [ICD-11: 2B70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Esophagus
The Specific Disease Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.057676692; Fold-change: -1.888133123; Z-score: -1.234848879
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rectal cancer [ICD-11: 2B92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.244628948; Fold-change: -0.656351587; Z-score: -0.481853717
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.047064581; Fold-change: -1.786672914; Z-score: -1.421597692
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Skin cancer [ICD-11: 2C30-2C3Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.14E-29; Fold-change: 0.683114573; Z-score: 1.479986786
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.10E-41; Fold-change: 1.016961659; Z-score: 2.368773576
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Renal cancer [ICD-11: 2C90-2C91]
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Differential expression pattern of antigen in diseases
The Studied Tissue Kidney
The Specific Disease Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.00157132; Fold-change: 0.117830818; Z-score: 0.474667145
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.249554837; Fold-change: -0.242640762; Z-score: -0.385062914
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ureter cancer [ICD-11: 2C92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Urothelium
The Specific Disease Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.237401496; Fold-change: -0.202519707; Z-score: -0.818217249
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 20
Click to Show/Hide the 2 Disease of This Class
Simpson golabi behmel syndrome [ICD-11: LD2C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adipose
The Specific Disease Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.271294134; Fold-change: -0.187430744; Z-score: -1.660131291
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Tuberous sclerosis complex [ICD-11: LD2D.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Perituberal
The Specific Disease Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.170821227; Fold-change: 0.081955621; Z-score: 0.624737608
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 3
Click to Show/Hide the 3 Disease of This Class
Anemia [ICD-11: 3A00-3A9Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.51481739; Fold-change: -0.683204939; Z-score: -0.493936034
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sickle cell disease [ICD-11: 3A51.0-3A51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.499511545; Fold-change: -0.777629184; Z-score: -0.802899422
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thrombocythemia [ICD-11: 3B63]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.56E-05; Fold-change: -0.63700321; Z-score: -1.201965685
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 4
Click to Show/Hide the 4 Disease of This Class
Scleroderma [ICD-11: 4A42.Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.11E-08; Fold-change: -2.090662208; Z-score: -3.547420246
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sjogren syndrome [ICD-11: 4A43]
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Differential expression pattern of antigen in diseases
The Studied Tissue Salivary gland
The Specific Disease Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.787638636; Fold-change: -0.977282137; Z-score: -0.673081188
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.001010061; Fold-change: 1.275611118; Z-score: 4.440124437
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Behcet disease [ICD-11: 4A62]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.241658144; Fold-change: -0.9303581; Z-score: -0.932813523
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autosomal dominant monocytopenia [ICD-11: 4B04]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.003480785; Fold-change: -0.347656672; Z-score: -0.845483951
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 5
Click to Show/Hide the 5 Disease of This Class
Type 2 diabetes [ICD-11: 5A11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.985177101; Fold-change: 0.136117637; Z-score: 0.218291815
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Polycystic ovary syndrome [ICD-11: 5A80.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Vastus lateralis muscle
The Specific Disease Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.41695012; Fold-change: -0.049126772; Z-score: -0.384608856
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Obesity [ICD-11: 5B81]
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Differential expression pattern of antigen in diseases
The Studied Tissue Subcutaneous Adipose
The Specific Disease Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.477965615; Fold-change: 0.06439992; Z-score: 0.202819803
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pompe disease [ICD-11: 5C51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Biceps muscle
The Specific Disease Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.189016426; Fold-change: -0.031245271; Z-score: -0.233709723
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Batten disease [ICD-11: 5C56.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.695532482; Fold-change: 0.624249052; Z-score: 1.200500399
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 6
Click to Show/Hide the 2 Disease of This Class
Autism [ICD-11: 6A02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.144859215; Fold-change: -0.120786224; Z-score: -0.175226579
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Anxiety disorder [ICD-11: 6B00-6B0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.023079021; Fold-change: -0.163538991; Z-score: -0.27725982
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 8
Click to Show/Hide the 7 Disease of This Class
Parkinson disease [ICD-11: 8A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Substantia nigra
The Specific Disease Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.027445971; Fold-change: 0.038450741; Z-score: 0.539669446
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Huntington disease [ICD-11: 8A01]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.969477236; Fold-change: -0.126589189; Z-score: -0.128362436
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alzheimer disease [ICD-11: 8A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Entorhinal cortex
The Specific Disease Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.968740191; Fold-change: -0.006823825; Z-score: -0.031064468
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Seizure [ICD-11: 8A60-8A6Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.774185603; Fold-change: 0.373969869; Z-score: 0.429648344
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lateral sclerosis [ICD-11: 8B60.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.25841382; Fold-change: 0.176360808; Z-score: 0.937511057
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Cervical spinal cord
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.991201675; Fold-change: -0.043734917; Z-score: -0.159948453
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Muscular atrophy [ICD-11: 8C70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.025410278; Fold-change: 0.138806267; Z-score: 1.080750904
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myopathy [ICD-11: 8C70.6]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.006783579; Fold-change: 0.183174411; Z-score: 1.031779028
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
References
Ref 1 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 2 A Dose Escalation Phase Ia Study of Anti-CD20 Antibody Drug Conjugate, MRG001 in Relapsed/Refractory Advanced Non-Hodgkin Lymphom. Blood. 2021 ;138():-. doi: 10.1182/blood-2021-144829.
Ref 3 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 4 Neodegrader conjugates; 2021-10-07.
Ref 5 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 6 EDC technology company product EDC9
Ref 7 Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies. Bioconjug Chem. 2019 Aug 21;30(8):2127-2135. doi: 10.1021/acs.bioconjchem.9b00363. Epub 2019 Jul 12.
Ref 8 Conjugates comprising self-immolative groups and methods related thereto.
Ref 9 NaPi2b targeting antibody-drug conjugates and methods of use thereof.
Ref 10 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 11 Open-label Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Auriim.
Ref 12 A phase 1 study of TRS005 in patients with R/R CD20-positive B-NHL.
Ref 13 Introduction to basic information on ADC drug APEC-1.
Ref 14 Tasly pharma announcement; 2020

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