Antigen Information

General Information of This Antigen (ID: TAR0BKUOF)
Antigen Name
B-lymphocyte antigen CD20 (MS4A1)
Gene Name
MS4A1
Gene ID
931
Synonym
CD20; B-lymphocyte surface antigen B1;Bp35;Leukocyte surface antigen Leu-16;Membrane-spanning 4-domains subfamily A member 1;CD20
Sequence
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP

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Family
MHC class II family
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

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Uniprot Entry
CD20_HUMAN
HGNC ID
HGNC:7315
KEGG ID
hsa:931
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD20 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TRS005
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CD20-A Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD20-A Antibody-Compound (X) [1]
CD20-A Antibody-Compound (X) payload
Undisclosed
CD20-A Antibody-Compound (X) linker
 ADC Info 
CD20-A Antibody-Compound (XI) [1]
CD20-A Antibody-Compound (XI) payload
Undisclosed
CD20-A Antibody-Compound (XI) linker
 ADC Info 
CD20-A Antibody-Compound (XIV) [1]
CD20-A Antibody-Compound (XIV) payload
Undisclosed
CD20-A Antibody-Compound (XIV) linker
 ADC Info 
CD20-A Antibody-Compound (XVIII) [1]
CD20-A Antibody-Compound (XVIII) payload
Undisclosed
CD20-A Antibody-Compound (XVIII) linker
 ADC Info 
CD20-A Antibody-Compound (Ie) [1]
CD20-A Antibody-Compound (Ie) payload
Undisclosed
CD20-A Antibody-Compound (Ie) linker
 ADC Info 
CD20-A Antibody-Compound (XIX) [1]
CD20-A Antibody-Compound (XIX) payload
Undisclosed
CD20-A Antibody-Compound (XIX) linker
 ADC Info 
CD20-A Antibody-Compound (Ii) [1]
CD20-A Antibody-Compound (Ii) payload
Undisclosed
CD20-A Antibody-Compound (Ii) linker
 ADC Info 
CD20-A Antibody-Compound (XLI) [1]
CD20-A Antibody-Compound (XLI) payload
Undisclosed
CD20-A Antibody-Compound (XLI) linker
 ADC Info 
CD20-A Antibody-Compound (XVI) [1]
CD20-A Antibody-Compound (XIX) payload
Undisclosed
CD20-A Antibody-Compound (XIX) linker
 ADC Info 
CD20-A Antibody-Compound (XL) [1]
CD20-A Antibody-Compound (XL) payload
Undisclosed
CD20-A Antibody-Compound (XL) linker
 ADC Info 
CD20-A Antibody-Compound (XLIII) [1]
CD20-A Antibody-Compound (XLIII) payload
Undisclosed
CD20-A Antibody-Compound (XLIII) linker
 ADC Info 
CD20-A Antibody-Compound (XLII) [1]
CD20-A Antibody-Compound (XLII) payload
Undisclosed
CD20-A Antibody-Compound (XLII) linker
 ADC Info 
CD20-A Antibody-Compound (XV) [1]
CD20-A Antibody-Compound (XV) payload
Undisclosed
CD20-A Antibody-Compound (XV) linker
 ADC Info 
CD20-A antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AU2023226367A1-3b [2]
Auristatin E
Microtubule (MT)
RU20241285-3-linker
 ADC Info 
Chimeric anti-CD20 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MRG001
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EP4487874A1-3b [3]
undisclosed
Undisclosed
EP4487874A1-3linker
 ADC Info 
Ibritumomab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ibritumomab-Compound 9 [4]
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 9 linker
 ADC Info 
Ibritumomab-Compound 17 [4]
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 17 linker
 ADC Info 
Ibritumomab-Compound 25 [4]
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 25 linker
 ADC Info 
Ibritumomab-Compound 31 [4]
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 31 linker
 ADC Info 
Ibritumomab-Compound 36 [4]
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 36 linker
 ADC Info 
Ibritumomab-Compound 43 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 43 linker
 ADC Info 
Ibritumomab-Compound 49 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 49 linker
 ADC Info 
Ibritumomab-Compound 55 [4]
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 55 linker
 ADC Info 
Ibritumomab-Compound 59 [4]
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 59 linker
 ADC Info 
Ibritumomab-Compound 64 [4]
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 64 linker
 ADC Info 
Ibritumomab-Compound 69 [4]
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 69 linker
 ADC Info 
Ibritumomab-Compound 74 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 74 linker
 ADC Info 
Ibritumomab-Compound 75 [4]
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 75 linker
 ADC Info 
Ibritumomab-Compound 76 [4]
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 76 linker
 ADC Info 
Ibritumomab-Compound 77 [4]
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 77 linker
 ADC Info 
Ibritumomab-Compound 78 [4]
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 78 linker
 ADC Info 
Ibritumomab-Compound 79 [4]
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 79 linker
 ADC Info 
Ibritumomab-Compound 80 [4]
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 80 linker
 ADC Info 
Laprituximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7623413B2 ExampleADC59 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024140927A1-ADC-H (DAR2) [6]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
WO2024140927A1-ADC-I (DAR2) [6]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Ofatumumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ofatumumab-Compound 9 [4]
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 9 linker
 ADC Info 
Ofatumumab-Compound 17 [4]
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 17 linker
 ADC Info 
Ofatumumab-Compound 25 [4]
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 25 linker
 ADC Info 
Ofatumumab-Compound 31 [4]
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 31 linker
 ADC Info 
Ofatumumab-Compound 36 [4]
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 36 linker
 ADC Info 
Ofatumumab-Compound 43 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 43 linker
 ADC Info 
Ofatumumab-Compound 49 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 49 linker
 ADC Info 
Ofatumumab-Compound 55 [4]
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 55 linker
 ADC Info 
Ofatumumab-Compound 59 [4]
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 59 linker
 ADC Info 
Ofatumumab-Compound 64 [4]
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 64 linker
 ADC Info 
Ofatumumab-Compound 69 [4]
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 69 linker
 ADC Info 
Ofatumumab-Compound 74 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 74 linker
 ADC Info 
Ofatumumab-Compound 75 [4]
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 75 linker
 ADC Info 
Ofatumumab-Compound 76 [4]
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 76 linker
 ADC Info 
Ofatumumab-Compound 77 [4]
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 77 linker
 ADC Info 
Ofatumumab-Compound 78 [4]
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 78 linker
 ADC Info 
Ofatumumab-Compound 79 [4]
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 79 linker
 ADC Info 
Ofatumumab-Compound 80 [4]
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 80 linker
 ADC Info 
Rituximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Aurixim
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
EDC-9 [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-DNA conjugate [8]
DNA mimics
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
Rituximab-Compound (la) DAR 8 [9]
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (la) linker
 ADC Info 
Rituximab-Compound (lc) [9]
NeoDegrader P4
Protein cereblon (CRBN)
Rituximab-Compound (lc) linker
 ADC Info 
Rituximab-Compound (le) [9]
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (le) linker
 ADC Info 
Rituximab-Compound (lf) [9]
NeoDegrader P6
Protein cereblon (CRBN)
Rituximab-Compound (lf) linker
 ADC Info 
Rituximab-Compound (lg) [9]
NeoDegrader P2
Protein cereblon (CRBN)
Rituximab-Compound (lg) linker
 ADC Info 
Rituximab-Compound (lh) [9]
NeoDegrader P13
Protein cereblon (CRBN)
Rituximab-Compound (lh) linker
 ADC Info 
Rituximab-Compound (li) [9]
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (li) linker
 ADC Info 
Rituximab-Compound (lj) [9]
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (lj) linker
 ADC Info 
Rituximab-Compound (lk) [9]
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (lk) linker
 ADC Info 
Rituximab-Compound (ll) [9]
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (ll) linker
 ADC Info 
Rituximab-Compound (lm) [9]
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (lm) linker
 ADC Info 
Rituximab-Compound (la) DAR 4 [9]
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (la) linker
 ADC Info 
WO2017089895A1 ADC70 [10]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC70 linker
 ADC Info 
WO2017089895A1 ADC71 [10]
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC71 linker
 ADC Info 
WO2017089895A1 ADC72 [10]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC72 linker
 ADC Info 
Rituximab-Compound (X) [1]
Rituximab-Compound (X) payload
Undisclosed
Rituximab-Compound (X) linker
 ADC Info 
Rituximab-Compound (XI) [1]
Rituximab-Compound (XI) payload
Undisclosed
Rituximab-Compound (XI) linker
 ADC Info 
Rituximab-Compound (XIV) [1]
Rituximab-Compound (XIV) payload
Undisclosed
Rituximab-Compound (XIV) linker
 ADC Info 
Rituximab-Compound (XVIII) [1]
Rituximab-Compound (XVIII) payload
Undisclosed
Rituximab-Compound (XVIII) linker
 ADC Info 
Rituximab-Compound (Ie) [1]
Rituximab-Compound (Ie) payload
Undisclosed
Rituximab-Compound (Ie) linker
 ADC Info 
Rituximab-Compound (XIX) [1]
Rituximab-Compound (XIX) payload
Undisclosed
Rituximab-Compound (XIX) linker
 ADC Info 
Rituximab-Compound (Ii) [1]
Rituximab-Compound (Ii) payload
Undisclosed
Rituximab-Compound (Ii) linker
 ADC Info 
Rituximab-Compound (XLI) [1]
Rituximab-Compound (XLI) payload
Undisclosed
Rituximab-Compound (XLI) linker
 ADC Info 
Rituximab-Compound (XVI) [1]
Rituximab-Compound (XIX) payload
Undisclosed
Rituximab-Compound (XIX) linker
 ADC Info 
Rituximab-Compound (XL) [1]
Rituximab-Compound (XL) payload
Undisclosed
Rituximab-Compound (XL) linker
 ADC Info 
Rituximab-Compound (XLIII) [1]
Rituximab-Compound (XLIII) payload
Undisclosed
Rituximab-Compound (XLIII) linker
 ADC Info 
Rituximab-Compound (XLII) [1]
Rituximab-Compound (XLII) payload
Undisclosed
Rituximab-Compound (XLII) linker
 ADC Info 
Rituximab-Compound (XV) [1]
Rituximab-Compound (XV) payload
Undisclosed
Rituximab-Compound (XV) linker
 ADC Info 
WO2017089890A1 ADC70 [11]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC70 linker
 ADC Info 
WO2017089890A1 ADC71 [11]
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC71 linker
 ADC Info 
WO2017089890A1 ADC72 [11]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC72 linker
 ADC Info 
Rituximab-Compound 9 [4]
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 9 linker
 ADC Info 
Rituximab-Compound 17 [4]
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 17 linker
 ADC Info 
Rituximab-Compound 25 [4]
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 25 linker
 ADC Info 
Rituximab-Compound 31 [4]
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 31 linker
 ADC Info 
Rituximab-Compound 36 [4]
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 36 linker
 ADC Info 
Rituximab-Compound 43 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 43 linker
 ADC Info 
Rituximab-Compound 49 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 49 linker
 ADC Info 
Rituximab-Compound 55 [4]
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 55 linker
 ADC Info 
Rituximab-Compound 59 [4]
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 59 linker
 ADC Info 
Rituximab-Compound 64 [4]
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 64 linker
 ADC Info 
Rituximab-Compound 69 [4]
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 69 linker
 ADC Info 
Rituximab-Compound 74 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 74 linker
 ADC Info 
Rituximab-Compound 75 [4]
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 75 linker
 ADC Info 
Rituximab-Compound 76 [4]
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 76 linker
 ADC Info 
Rituximab-Compound 77 [4]
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 77 linker
 ADC Info 
Rituximab-Compound 78 [4]
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 78 linker
 ADC Info 
Rituximab-Compound 79 [4]
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 79 linker
 ADC Info 
Rituximab-Compound 80 [4]
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 80 linker
 ADC Info 
CN109310885B ADC-7 [12]
CN109310885B ADC-7 payload
Undisclosed
CN109310885B ADC-7 linker
 ADC Info 
CN109310885B ADC-8 [12]
CN109310885B ADC-8 payload
Undisclosed
CN109310885B ADC-8 linker
 ADC Info 
Rituximab-LplA-MMAE [13]
Monomethyl auristatin E
Microtubule (MT)
DBCO-Val-Cit-PABC
 ADC Info 
R-VCR 6a [14]
Vincristine (VCR)
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
R-VCR 6b [14]
Vincristine (VCR)
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
Rituximab-DM1 (K248) [15]
Mertansine DM1
Microtubule (MT)
Undisclosed
 ADC Info 
Rituximab-MMAE (K248) [15]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Rituximab-GDP-D-P1/P1-P1-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-D-P2/P8-P4-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-D-P2/P4-P4-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-D-P1/P1-P4-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-D-P1/P1-P2-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-D-P1/P1-C2-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-D-P2/P2-P2-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-N-P1/P1-P1-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd Linker
 ADC Info 
Rituximab-GDP-K-P2/P4-P4-GGFG-Dxd [16]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd Linker
 ADC Info 
JP7623413B2 ExampleADC48 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD12 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD3 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD4 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD5 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD6 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD7 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab-LD8 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ZA202500415A-ADC Example 2 [18]
NMT inhibitor 1
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
 ADC Info 
AU2020291014A1 IC-39 [19]
AU2020291014A1-Payload-35
Undisclosed
Undisclosed
 ADC Info 
AU2020291014A1 IC-63 [19]
AU2020291014A1-Payload-69
Undisclosed
Aminobenzazepine-linker Formula II-69
 ADC Info 
WO2019126691A1 Conjugate No.62 [20]
Conjugate No.60 Payload
Undisclosed
Conjugate No.5 Linker
 ADC Info 
WO2019126691A1 Conjugate No.94B [20]
Conjugate No.94 Payload
Undisclosed
Conjugate No.94 Linker
 ADC Info 
WO2019126691A1 Conjugate No.135A [20]
Conjugate No.135 Payload
Undisclosed
Conjugate No.105 Linker
 ADC Info 
WO2019126691A1 Conjugate No.136A [20]
Conjugate No.136 Payload
Undisclosed
Conjugate No.105 Linker
 ADC Info 
AU2023279443A1 Example A3b [21]
U-031
Microtubule (MT)
AU2023279443A1, Example A3, Linker
 ADC Info 
JP7560255B2 ControlADC48 [22]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
TWI857167B IC-33 [23]
TWI857167B IC-38 payload
Undisclosed
TWI857167B-IC-29-LINKER
 ADC Info 
JP2024501894A5-9 [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-10 [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-14 [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Rituximab (P41C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
KR1020250011922A ADC-RIT41C [25]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Tositumomab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tositumomab-Compound 9 [4]
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 9 linker
 ADC Info 
Tositumomab-Compound 17 [4]
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 17 linker
 ADC Info 
Tositumomab-Compound 25 [4]
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 25 linker
 ADC Info 
Tositumomab-Compound 31 [4]
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 31 linker
 ADC Info 
Tositumomab-Compound 36 [4]
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 36 linker
 ADC Info 
Tositumomab-Compound 43 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 43 linker
 ADC Info 
Tositumomab-Compound 49 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 49 linker
 ADC Info 
Tositumomab-Compound 55 [4]
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 55 linker
 ADC Info 
Tositumomab-Compound 59 [4]
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 59 linker
 ADC Info 
Tositumomab-Compound 64 [4]
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 64 linker
 ADC Info 
Tositumomab-Compound 69 [4]
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 69 linker
 ADC Info 
Tositumomab-Compound 74 [4]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 74 linker
 ADC Info 
Tositumomab-Compound 75 [4]
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 75 linker
 ADC Info 
Tositumomab-Compound 76 [4]
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 76 linker
 ADC Info 
Tositumomab-Compound 77 [4]
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 77 linker
 ADC Info 
Tositumomab-Compound 78 [4]
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 78 linker
 ADC Info 
Tositumomab-Compound 79 [4]
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 79 linker
 ADC Info 
Tositumomab-Compound 80 [4]
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 80 linker
 ADC Info 
Veltuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Veltuzumab-SN-38 [26]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Veltuzumab-CL2E-SN-38 [26]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
APEC-1 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
B-1452 [28]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CN108452318B ADC [29]
CN108452318B+ADC+payload
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
WO2024118785A3 Lot39 [30]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot40 [30]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot54 [30]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot74 [30]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 2 Antibody-drug conjugate
Ref 3 Antibody-drug conjugate precursor and intermediate for synthesis thereof
Ref 4 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 5 Antibody-drug complexes containing hemiasterlin derivatives
Ref 6 Use of hydroxypropyl-β-cyclodextrin in stabilizing antibody-drug conjugate formulations
Ref 7 EDC technology company product EDC9
Ref 8 Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies. Bioconjug Chem. 2019 Aug 21;30(8):2127-2135. doi: 10.1021/acs.bioconjchem.9b00363. Epub 2019 Jul 12.
Ref 9 Neodegrader conjugates; 2021-10-07.
Ref 10 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 11 Conjugates comprising self-immolative groups and methods related thereto.
Ref 12 NaPi2b targeting antibody-drug conjugates and methods of use thereof.
Ref 13 Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification
Ref 14 Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents
Ref 15 AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody-Drug Conjugate Synthesis
Ref 16 A drug conjugate and its preparation method and application
Ref 17 Non-linear self-immolative linkers and conjugates thereof
Ref 18 Antibody drug conjugate comprising NMT inhibitor and its use
Ref 19 Aminobenzazepine compounds, immunoconjugates, and uses thereof
Ref 20 Pyrrolobenzodiazepine antibody conjugates
Ref 21 Antibody-multidrug conjugate
Ref 22 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 23 Thienobenzodiazepine immunoconjugates and uses thereof
Ref 24 B7h4 targeting antibody-drug conjugate and its use
Ref 25 New shielded antibody
Ref 26 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 27 Introduction to basic information on ADC drug APEC-1.
Ref 28 Tasly pharma announcement; 2020
Ref 29 Anti-CD20 antibody-drug conjugates and their preparation methods and uses
Ref 30 TLR7 agonists and antibody-drug conjugates thereof