Antigen Information

General Information of This Antigen
Antigen ID
TAR0BKUOF
Antigen Name
B-lymphocyte antigen CD20 (MS4A1)
Gene Name
MS4A1
Gene ID
931
Synonym
CD20; B-lymphocyte surface antigen B1;Bp35;Leukocyte surface antigen Leu-16;Membrane-spanning 4-domains subfamily A member 1;CD_antigen=CD20
Sequence
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP

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Family
MHC class II family
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

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Uniprot Entry
CD20_HUMAN
HGNC ID
HGNC:7315
KEGG ID
hsa:931
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CD20 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TRS005
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
CD20-A Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD20-A Antibody-Compound (X)
CD20-A Antibody-Compound (X) payload
Undisclosed
CD20-A Antibody-Compound (X) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XI)
CD20-A Antibody-Compound (XI) payload
Undisclosed
CD20-A Antibody-Compound (XI) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XIV)
CD20-A Antibody-Compound (XIV) payload
Undisclosed
CD20-A Antibody-Compound (XIV) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XVIII)
CD20-A Antibody-Compound (XVIII) payload
Undisclosed
CD20-A Antibody-Compound (XVIII) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (Ie)
CD20-A Antibody-Compound (Ie) payload
Undisclosed
CD20-A Antibody-Compound (Ie) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XIX)
CD20-A Antibody-Compound (XIX) payload
Undisclosed
CD20-A Antibody-Compound (XIX) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (Ii)
CD20-A Antibody-Compound (Ii) payload
Undisclosed
CD20-A Antibody-Compound (Ii) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XLI)
CD20-A Antibody-Compound (XLI) payload
Undisclosed
CD20-A Antibody-Compound (XLI) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XVI)
CD20-A Antibody-Compound (XIX) payload
Undisclosed
CD20-A Antibody-Compound (XIX) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XL)
CD20-A Antibody-Compound (XL) payload
Undisclosed
CD20-A Antibody-Compound (XL) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XLIII)
CD20-A Antibody-Compound (XLIII) payload
Undisclosed
CD20-A Antibody-Compound (XLIII) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XLII)
CD20-A Antibody-Compound (XLII) payload
Undisclosed
CD20-A Antibody-Compound (XLII) linker
 [1]
 ADC Info 
CD20-A Antibody-Compound (XV)
CD20-A Antibody-Compound (XV) payload
Undisclosed
CD20-A Antibody-Compound (XV) linker
 [1]
CD20-A antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AU2023226367A1-3b
Auristatin E
Microtubule (MT)
RU20241285-3-linker
 [2]
Chimeric anti-CD20 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MRG001
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EP4487874A1-3b
undisclosed
Undisclosed
EP4487874A1-3linker
 [3]
Ibritumomab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ibritumomab-Compound 9
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 9 linker
 [4]
 ADC Info 
Ibritumomab-Compound 17
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 17 linker
 [4]
 ADC Info 
Ibritumomab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 25 linker
 [4]
 ADC Info 
Ibritumomab-Compound 31
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 31 linker
 [4]
 ADC Info 
Ibritumomab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 36 linker
 [4]
 ADC Info 
Ibritumomab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 43 linker
 [4]
 ADC Info 
Ibritumomab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 49 linker
 [4]
 ADC Info 
Ibritumomab-Compound 55
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 55 linker
 [4]
 ADC Info 
Ibritumomab-Compound 59
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 59 linker
 [4]
 ADC Info 
Ibritumomab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 64 linker
 [4]
 ADC Info 
Ibritumomab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 69 linker
 [4]
 ADC Info 
Ibritumomab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ibritumomab-Compound 74 linker
 [4]
 ADC Info 
Ibritumomab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 75 linker
 [4]
 ADC Info 
Ibritumomab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Ibritumomab-Compound 76 linker
 [4]
 ADC Info 
Ibritumomab-Compound 77
Mertansine DM1
Microtubule (MT)
Ibritumomab-Compound 77 linker
 [4]
 ADC Info 
Ibritumomab-Compound 78
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 78 linker
 [4]
 ADC Info 
Ibritumomab-Compound 79
Auristatin 0101
Microtubule (MT)
Ibritumomab-Compound 79 linker
 [4]
 ADC Info 
Ibritumomab-Compound 80
Mertansine DM4
Microtubule (MT)
Ibritumomab-Compound 80 linker
 [4]
Laprituximab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JP7623413B2 ExampleADC59
Undisclosed
Undisclosed
Undisclosed
 [5]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024140927A1-ADC-H (DAR2)
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [6]
 ADC Info 
WO2024140927A1-ADC-I (DAR2)
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [6]
Ofatumumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ofatumumab-Compound 9
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 9 linker
 [4]
 ADC Info 
Ofatumumab-Compound 17
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 17 linker
 [4]
 ADC Info 
Ofatumumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 25 linker
 [4]
 ADC Info 
Ofatumumab-Compound 31
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 31 linker
 [4]
 ADC Info 
Ofatumumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 36 linker
 [4]
 ADC Info 
Ofatumumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 43 linker
 [4]
 ADC Info 
Ofatumumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 49 linker
 [4]
 ADC Info 
Ofatumumab-Compound 55
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 55 linker
 [4]
 ADC Info 
Ofatumumab-Compound 59
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 59 linker
 [4]
 ADC Info 
Ofatumumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 64 linker
 [4]
 ADC Info 
Ofatumumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 69 linker
 [4]
 ADC Info 
Ofatumumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ofatumumab-Compound 74 linker
 [4]
 ADC Info 
Ofatumumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 75 linker
 [4]
 ADC Info 
Ofatumumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Ofatumumab-Compound 76 linker
 [4]
 ADC Info 
Ofatumumab-Compound 77
Mertansine DM1
Microtubule (MT)
Ofatumumab-Compound 77 linker
 [4]
 ADC Info 
Ofatumumab-Compound 78
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 78 linker
 [4]
 ADC Info 
Ofatumumab-Compound 79
Auristatin 0101
Microtubule (MT)
Ofatumumab-Compound 79 linker
 [4]
 ADC Info 
Ofatumumab-Compound 80
Mertansine DM4
Microtubule (MT)
Ofatumumab-Compound 80 linker
 [4]
Rituximab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Aurixim
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
EDC-9
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Rituximab-DNA conjugate
DNA mimics
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [8]
 ADC Info 
Rituximab-Compound (la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (la) linker
 [9]
 ADC Info 
Rituximab-Compound (lc)
NeoDegrader P4
Protein cereblon (CRBN)
Rituximab-Compound (lc) linker
 [9]
 ADC Info 
Rituximab-Compound (le)
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (le) linker
 [9]
 ADC Info 
Rituximab-Compound (lf)
NeoDegrader P6
Protein cereblon (CRBN)
Rituximab-Compound (lf) linker
 [9]
 ADC Info 
Rituximab-Compound (lg)
NeoDegrader P2
Protein cereblon (CRBN)
Rituximab-Compound (lg) linker
 [9]
 ADC Info 
Rituximab-Compound (lh)
NeoDegrader P13
Protein cereblon (CRBN)
Rituximab-Compound (lh) linker
 [9]
 ADC Info 
Rituximab-Compound (li)
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (li) linker
 [9]
 ADC Info 
Rituximab-Compound (lj)
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (lj) linker
 [9]
 ADC Info 
Rituximab-Compound (lk)
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (lk) linker
 [9]
 ADC Info 
Rituximab-Compound (ll)
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (ll) linker
 [9]
 ADC Info 
Rituximab-Compound (lm)
NeoDegrader P14
Protein cereblon (CRBN)
Rituximab-Compound (lm) linker
 [9]
 ADC Info 
Rituximab-Compound (la) DAR 4
NeoDegrader P1
Protein cereblon (CRBN)
Rituximab-Compound (la) linker
 [9]
 ADC Info 
WO2017089895A1 ADC70
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC70 linker
 [10]
 ADC Info 
WO2017089895A1 ADC71
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC71 linker
 [10]
 ADC Info 
WO2017089895A1 ADC72
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC72 linker
 [10]
 ADC Info 
Rituximab-Compound (X)
Rituximab-Compound (X) payload
Undisclosed
Rituximab-Compound (X) linker
 [1]
 ADC Info 
Rituximab-Compound (XI)
Rituximab-Compound (XI) payload
Undisclosed
Rituximab-Compound (XI) linker
 [1]
 ADC Info 
Rituximab-Compound (XIV)
Rituximab-Compound (XIV) payload
Undisclosed
Rituximab-Compound (XIV) linker
 [1]
 ADC Info 
Rituximab-Compound (XVIII)
Rituximab-Compound (XVIII) payload
Undisclosed
Rituximab-Compound (XVIII) linker
 [1]
 ADC Info 
Rituximab-Compound (Ie)
Rituximab-Compound (Ie) payload
Undisclosed
Rituximab-Compound (Ie) linker
 [1]
 ADC Info 
Rituximab-Compound (XIX)
Rituximab-Compound (XIX) payload
Undisclosed
Rituximab-Compound (XIX) linker
 [1]
 ADC Info 
Rituximab-Compound (Ii)
Rituximab-Compound (Ii) payload
Undisclosed
Rituximab-Compound (Ii) linker
 [1]
 ADC Info 
Rituximab-Compound (XLI)
Rituximab-Compound (XLI) payload
Undisclosed
Rituximab-Compound (XLI) linker
 [1]
 ADC Info 
Rituximab-Compound (XVI)
Rituximab-Compound (XIX) payload
Undisclosed
Rituximab-Compound (XIX) linker
 [1]
 ADC Info 
Rituximab-Compound (XL)
Rituximab-Compound (XL) payload
Undisclosed
Rituximab-Compound (XL) linker
 [1]
 ADC Info 
Rituximab-Compound (XLIII)
Rituximab-Compound (XLIII) payload
Undisclosed
Rituximab-Compound (XLIII) linker
 [1]
 ADC Info 
Rituximab-Compound (XLII)
Rituximab-Compound (XLII) payload
Undisclosed
Rituximab-Compound (XLII) linker
 [1]
 ADC Info 
Rituximab-Compound (XV)
Rituximab-Compound (XV) payload
Undisclosed
Rituximab-Compound (XV) linker
 [1]
 ADC Info 
WO2017089890A1 ADC70
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC70 linker
 [11]
 ADC Info 
WO2017089890A1 ADC71
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC71 linker
 [11]
 ADC Info 
WO2017089890A1 ADC72
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC72 linker
 [11]
 ADC Info 
Rituximab-Compound 9
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 9 linker
 [4]
 ADC Info 
Rituximab-Compound 17
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 17 linker
 [4]
 ADC Info 
Rituximab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 25 linker
 [4]
 ADC Info 
Rituximab-Compound 31
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 31 linker
 [4]
 ADC Info 
Rituximab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 36 linker
 [4]
 ADC Info 
Rituximab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 43 linker
 [4]
 ADC Info 
Rituximab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 49 linker
 [4]
 ADC Info 
Rituximab-Compound 55
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 55 linker
 [4]
 ADC Info 
Rituximab-Compound 59
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 59 linker
 [4]
 ADC Info 
Rituximab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 64 linker
 [4]
 ADC Info 
Rituximab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 69 linker
 [4]
 ADC Info 
Rituximab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Rituximab-Compound 74 linker
 [4]
 ADC Info 
Rituximab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 75 linker
 [4]
 ADC Info 
Rituximab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Rituximab-Compound 76 linker
 [4]
 ADC Info 
Rituximab-Compound 77
Mertansine DM1
Microtubule (MT)
Rituximab-Compound 77 linker
 [4]
 ADC Info 
Rituximab-Compound 78
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 78 linker
 [4]
 ADC Info 
Rituximab-Compound 79
Auristatin 0101
Microtubule (MT)
Rituximab-Compound 79 linker
 [4]
 ADC Info 
Rituximab-Compound 80
Mertansine DM4
Microtubule (MT)
Rituximab-Compound 80 linker
 [4]
 ADC Info 
CN109310885B ADC-7
CN109310885B ADC-7 payload
Undisclosed
CN109310885B ADC-7 linker
 [12]
 ADC Info 
CN109310885B ADC-8
CN109310885B ADC-8 payload
Undisclosed
CN109310885B ADC-8 linker
 [12]
 ADC Info 
Rituximab-LplA-MMAE
Monomethyl auristatin E
Microtubule (MT)
DBCO-Val-Cit-PABC
 [13]
 ADC Info 
R-VCR 6a
Vincristine (VCR)
Undisclosed
Mc-Val-Cit-PABC
 [14]
 ADC Info 
R-VCR 6b
Vincristine (VCR)
Undisclosed
Mc-Val-Cit-PABC
 [14]
 ADC Info 
Rituximab-DM1 (K248)
Mertansine DM1
Microtubule (MT)
Undisclosed
 [15]
 ADC Info 
Rituximab-MMAE (K248)
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [15]
 ADC Info 
Rituximab-GDP-D-P1/P1-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P1-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-D-P2/P8-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-D-P2/P4-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-D-P1/P1-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-D-P1/P1-P2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-D-P1/P1-C2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-D-P2/P2-P2-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-N-P1/P1-P1-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
CN119326907A Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd Linker
 [16]
 ADC Info 
Rituximab-GDP-K-P2/P4-P4-GGFG-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Trastuzumab-GDP-D-P2/P2-P2-GGFG-Dxd Linker
 [16]
 ADC Info 
JP7623413B2 ExampleADC48
Undisclosed
Undisclosed
Undisclosed
 [5]
 ADC Info 
Rituximab-LD12
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
Rituximab-LD3
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
Rituximab-LD4
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
Rituximab-LD5
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
Rituximab-LD6
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
Rituximab-LD7
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
Rituximab-LD8
Undisclosed
Undisclosed
Undisclosed
 [17]
 ADC Info 
ZA202500415A-ADC Example 2
NMT inhibitor 1
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
 [18]
 ADC Info 
AU2020291014A1 IC-39
AU2020291014A1-Payload-35
Undisclosed
Undisclosed
 [19]
 ADC Info 
AU2020291014A1 IC-63
AU2020291014A1-Payload-69
Undisclosed
Aminobenzazepine-linker Formula II-69
 [19]
 ADC Info 
WO2019126691A1 Conjugate No.62
Conjugate No.60 Payload
Undisclosed
Conjugate No.5 Linker
 [20]
 ADC Info 
WO2019126691A1 Conjugate No.94B
Conjugate No.94 Payload
Undisclosed
Conjugate No.94 Linker
 [20]
 ADC Info 
WO2019126691A1 Conjugate No.135A
Conjugate No.135 Payload
Undisclosed
Conjugate No.105 Linker
 [20]
 ADC Info 
WO2019126691A1 Conjugate No.136A
Conjugate No.136 Payload
Undisclosed
Conjugate No.105 Linker
 [20]
 ADC Info 
AU2023279443A1 Example A3b
U-031
Microtubule (MT)
AU2023279443A1, Example A3, Linker
 [21]
 ADC Info 
JP7560255B2 ControlADC48
Undisclosed
Undisclosed
Undisclosed
 [22]
 ADC Info 
TWI857167B IC-33
TWI857167B IC-38 payload
Undisclosed
TWI857167B-IC-29-LINKER
 [23]
 ADC Info 
JP2024501894A5-9
Undisclosed
Undisclosed
Undisclosed
 [24]
 ADC Info 
JP2024501894A5-10
Undisclosed
Undisclosed
Undisclosed
 [24]
 ADC Info 
JP2024501894A5-14
Undisclosed
Undisclosed
Undisclosed
 [24]
Rituximab (P41C)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
KR1020250011922A ADC-RIT41C
Undisclosed
Undisclosed
Undisclosed
 [25]
Tositumomab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Tositumomab-Compound 9
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 9 linker
 [4]
 ADC Info 
Tositumomab-Compound 17
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 17 linker
 [4]
 ADC Info 
Tositumomab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 25 linker
 [4]
 ADC Info 
Tositumomab-Compound 31
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 31 linker
 [4]
 ADC Info 
Tositumomab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 36 linker
 [4]
 ADC Info 
Tositumomab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 43 linker
 [4]
 ADC Info 
Tositumomab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 49 linker
 [4]
 ADC Info 
Tositumomab-Compound 55
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 55 linker
 [4]
 ADC Info 
Tositumomab-Compound 59
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 59 linker
 [4]
 ADC Info 
Tositumomab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 64 linker
 [4]
 ADC Info 
Tositumomab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 69 linker
 [4]
 ADC Info 
Tositumomab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Tositumomab-Compound 74 linker
 [4]
 ADC Info 
Tositumomab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 75 linker
 [4]
 ADC Info 
Tositumomab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Tositumomab-Compound 76 linker
 [4]
 ADC Info 
Tositumomab-Compound 77
Mertansine DM1
Microtubule (MT)
Tositumomab-Compound 77 linker
 [4]
 ADC Info 
Tositumomab-Compound 78
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 78 linker
 [4]
 ADC Info 
Tositumomab-Compound 79
Auristatin 0101
Microtubule (MT)
Tositumomab-Compound 79 linker
 [4]
 ADC Info 
Tositumomab-Compound 80
Mertansine DM4
Microtubule (MT)
Tositumomab-Compound 80 linker
 [4]
Veltuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Veltuzumab-SN-38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [26]
 ADC Info 
Veltuzumab-CL2E-SN-38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
 [26]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
APEC-1
Undisclosed
Undisclosed
Undisclosed
 [27]
 ADC Info 
B-1452
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [28]
 ADC Info 
CN108452318B ADC
CN108452318B+ADC+payload
Undisclosed
Mc-Val-Cit-PABC
 [29]
 ADC Info 
WO2024118785A3 Lot39
Undisclosed
Undisclosed
Undisclosed
 [30]
 ADC Info 
WO2024118785A3 Lot40
Undisclosed
Undisclosed
Undisclosed
 [30]
 ADC Info 
WO2024118785A3 Lot54
Undisclosed
Undisclosed
Undisclosed
 [30]
 ADC Info 
WO2024118785A3 Lot74
Undisclosed
Undisclosed
Undisclosed
 [30]
References
Ref 1 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 2 Antibody-drug conjugate
Ref 3 Antibody-drug conjugate precursor and intermediate for synthesis thereof
Ref 4 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 5 Antibody-drug complexes containing hemiasterlin derivatives
Ref 6 Use of hydroxypropyl-β-cyclodextrin in stabilizing antibody-drug conjugate formulations
Ref 7 EDC technology company product EDC9
Ref 8 Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies. Bioconjug Chem. 2019 Aug 21;30(8):2127-2135. doi: 10.1021/acs.bioconjchem.9b00363. Epub 2019 Jul 12.
Ref 9 Neodegrader conjugates; 2021-10-07.
Ref 10 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 11 Conjugates comprising self-immolative groups and methods related thereto.
Ref 12 NaPi2b targeting antibody-drug conjugates and methods of use thereof.
Ref 13 Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification
Ref 14 Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents
Ref 15 AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody-Drug Conjugate Synthesis
Ref 16 A drug conjugate and its preparation method and application
Ref 17 Non-linear self-immolative linkers and conjugates thereof
Ref 18 Antibody drug conjugate comprising NMT inhibitor and its use
Ref 19 Aminobenzazepine compounds, immunoconjugates, and uses thereof
Ref 20 Pyrrolobenzodiazepine antibody conjugates
Ref 21 Antibody-multidrug conjugate
Ref 22 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 23 Thienobenzodiazepine immunoconjugates and uses thereof
Ref 24 B7h4 targeting antibody-drug conjugate and its use
Ref 25 New shielded antibody
Ref 26 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 27 Introduction to basic information on ADC drug APEC-1.
Ref 28 Tasly pharma announcement; 2020
Ref 29 Anti-CD20 antibody-drug conjugates and their preparation methods and uses
Ref 30 TLR7 agonists and antibody-drug conjugates thereof