Antigen ID	TAR0AABNG
Antigen Name	Sodium-dependent phosphate transport protein 2B (SLC34A2)
Gene Name	SLC34A2
Gene ID	10568
Synonym	Na(+)-dependent phosphate cotransporter 2B;NaPi3b;Sodium/phosphate cotransporter 2B;Solute carrier family 34 member 2
Sequence	MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLI DEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSS AFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRA AIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHY LEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVK IWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLP DLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAI LVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNA LRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLI PLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSL KPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVK APETFDNITISREAQGEVPASDSKTECTAL     Click to Show/Hide
Family	SEZ6 family
Function	Involved in actively transporting phosphate into cells via Na(+) cotransport.     Click to Show/Hide
Uniprot Entry	NPT2B_HUMAN
HGNC ID	HGNC:11020
KEGG ID	hsa:10568

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN109310885B ADC-4	CN109310885B ADC-4 payload	Undisclosed	CN109310885B ADC-4 linker	[1]
ADC Info	CN109310885B ADC-5	CN109310885B ADC-5 payload	Undisclosed	CN109310885B ADC-5 linker	[1]
ADC Info	CN109310885B ADC-6	CN109310885B ADC-6 payload	Undisclosed	CN109310885B ADC-6 linker	[1]
ADC Info	CN109310885B ADC-9	CN109310885B ADC-9 payload	Undisclosed	CN109310885B ADC-9 linker	[1]
ADC Info	CN109310885B ADC-10	CN109310885B ADC-10 payload	Undisclosed	CN109310885B ADC-10 linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN106714844B ADC-121	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[2]
ADC Info	CN106714844B ADC-123	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[2]
ADC Info	CN106714844B ADC-125	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[2]
ADC Info	CN106714844B ADC-127	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[2]
ADC Info	CN107206101B ADC-1	Dolastatin10	Undisclosed	MC-Sq-CIt-PAB	[3]
ADC Info	CN107206101B ADC-2-1	Tubulysin M	Undisclosed	MC-Sq-CIt-PAB	[3]
ADC Info	Anti- Napi2b Disulfide-Tubulysin M	Tubulysin M	Undisclosed	Disulfide linker	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN106714844B ADC-106	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[2]
ADC Info	CN106714844B ADC-113	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	XMT-1592	AF-HPA	Microtubule (MT)	Cys-13 ADC linker

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TUB-040	Exatecan	DNA topoisomerase 1 (TOP1)	P5 (PEG24)-Val-Cit-PABC

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	YL205	YL0010014	DNA topoisomerase 1 (TOP1)	VK*G-NHCH2-O linker

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	NaPi2b PNU ADC3-1	NaPi2b PNU ADC3-1 payload	Undisclosed	NaPi2b PNU ADC3-1 linker	[4]
ADC Info	NaPi2b PNU ADC4-1	NaPi2b PNU ADC4-1 payload	Undisclosed	NaPi2b PNU ADC4-1 linker	[4]
ADC Info	NaPi2b-PNU-LD1	NaPi2b-PNU-LD1 payload	Undisclosed	NaPi2b-PNU-LD1 linker	[4]
ADC Info	NaPi2b-PNU-LD2	NaPi2b-PNU-LD2 payload	Undisclosed	NaPi2b-PNU-LD2 linker	[4]
ADC Info	NaPi2b-PNU-LD5	NaPi2b-PNU-LD5 payload	Undisclosed	NaPi2b-PNU-LD5 linker	[4]
ADC Info	NaPi2b-PNU-LD6	NaPi2b-PNU-LD6 payload	Undisclosed	NaPi2b-PNU-LD6 linker	[4]
ADC Info	NaPi2b-PNU-LD7	NaPi2b-PNU-LD7 payload	Undisclosed	NaPi2b-PNU-LD7 linker	[4]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Alpha-NaPi2b-LC-K149C-10	seco-CBI-dimer	Human Deoxyribonucleic acid (hDNA)	Mc-peptidomimetic based linker 10	[5]
ADC Info	Alpha-NaPi2b-LC-K149C-11	seco-CBI-dimer	Human Deoxyribonucleic acid (hDNA)	Mal-PEG2	[5]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN105828840B ADC-134	CN105828840B_ADC-134 payload	Undisclosed	CN105828840B_ADC-134 linker	[6]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN105828840B ADC-135	CN105828840B_ADC-135 payload	Undisclosed	CN105828840B_ADC-135 linker	[6]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN105828840B ADC-136	CN105828840B_ADC-136 payload	Undisclosed	CN105828840B_ADC-136 linker	[6]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	ZW-220	ZD06519	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly-AM	[7]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Lifastuzumab vedotin	MMAE	Microtubule (MT)	Mc-Val-Cit-PABC

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AGL-01332-93 (BrAc) 2.43	CN114929286A 93	Undisclosed	AGL-01332 linker	[8]
ADC Info	AGL-01332-93CI 2.19	CN114929286A 93CI	Undisclosed	AGL-01332 linker	[8]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AGL-01332-93 (BrAc) 1.98	CN114929286A 93	Undisclosed	AGL-01332 linker	[8]
ADC Info	AGL-01332-93CI 1.82	CN114929286A 93CI	Undisclosed	AGL-01332 linker	[8]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2017214024A1 ADC-102	WO2017214024A1_ADC-102 payload	Undisclosed	WO2017214024A1_ADC-102 linker	[9]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2017059289A1 ADC-208	WO2017059289A1_ADC-208 payload	Undisclosed	WO2017059289A1_ADC-208 linker	[10]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2014159981A2 ADC-205	WO2014159981A2_ADC-205 payload	Undisclosed	WO2014159981A2_ADC-205 linker	[11]
ADC Info	WO2014159981A2 ADC-SLC34A2-33	WO2014159981A2_ADC-SLC34A2-33 payload	Undisclosed	WO2014159981A2_ADC-SLC34A2-33 linker	[11]
ADC Info	WO2014159981A2 ADC-SLC34A2-37	WO2014159981A2_ADC-SLC34A2-37 payload	Undisclosed	WO2014159981A2_ADC-SLC34A2-37 linker	[11]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Upifitamab rilsodotin	AF-HPA	Microtubule (MT)	Dolaflexin polymer

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2018098269A2 conjugate 53A	WO2018098269A2_conjugate 53A payload	Undisclosed	WO2018098269A2_conjugate 53A linker	[12]
ADC Info	WO2018098269A2 conjugate 55A	WO2018098269A2_conjugate 55A payload	Undisclosed	WO2018098269A2_conjugate 55A linker	[12]
ADC Info	WO2018098269A2 conjugate 57	WO2018098269A2_conjugate 57 payload	Undisclosed	WO2018098269A2_conjugate 57 linker	[12]
ADC Info	WO2018098269A2 conjugate 59	WO2018098269A2_conjugate 59 payload	Undisclosed	WO2018098269A2_conjugate 59 linker	[12]
ADC Info	WO2018098269A2 conjugate 61	WO2018098269A2_conjugate 61 payload	Undisclosed	WO2018098269A2_conjugate 61 linker	[12]
ADC Info	WO2018098269A2 conjugate 66	WO2018098269A2_conjugate 66 payload	Undisclosed	WO2018098269A2_conjugate 66 linker	[12]
ADC Info	WO2018098269A2 conjugate 79A	WO2018098269A2_conjugate 79A payload	Undisclosed	WO2018098269A2_conjugate 79A linker	[12]
ADC Info	WO2018098269A2 conjugate 76	WO2018098269A2_conjugate 76 payload	Undisclosed	WO2018098269A2_conjugate 76 linker	[12]
ADC Info	WO2018098269A2 conjugate 83	WO2018098269A2_conjugate 83 payload	Undisclosed	WO2018098269A2_conjugate 83 linker	[12]
ADC Info	WO2018098269A2 conjugate 78	WO2018098269A2_conjugate 78 payload	Undisclosed	WO2018098269A2_conjugate 78 linker	[12]
ADC Info	WO2018098269A2 conjugate 85	WO2018098269A2_conjugate 85 payload	Undisclosed	WO2018098269A2_conjugate 85 linker	[12]
ADC Info	WO2018098269A2 conjugate 53B	WO2018098269A2_conjugate 53B payload	Undisclosed	WO2018098269A2_conjugate 53B linker	[12]
ADC Info	WO2018098269A2 conjugate 53C	WO2018098269A2_conjugate 53C payload	Undisclosed	WO2018098269A2_conjugate 53C linker	[12]
ADC Info	WO2018098269A2 conjugate 53D	WO2018098269A2_conjugate 53D payload	Undisclosed	WO2018098269A2_conjugate 53D linker	[12]
ADC Info	WO2018098269A2 conjugate 53E	WO2018098269A2_conjugate 53E payload	Undisclosed	WO2018098269A2_conjugate 53E linker	[12]
ADC Info	WO2018098269A2 conjugate 55B	WO2018098269A2_conjugate 55B payload	Undisclosed	WO2018098269A2_conjugate 55B linker	[12]
ADC Info	WO2018098269A2 conjugate 79B	WO2018098269A2_conjugate 79B payload	Undisclosed	WO2018098269A2_conjugate 79B linker	[12]
ADC Info	CN109310885B ADC-1	CN109310885B ADC-1 payload	Undisclosed	CN109310885B ADC-1 linker	[1]
ADC Info	CN109310885B ADC-2	CN109310885B ADC-2 payload	Undisclosed	CN109310885B ADC-2 linker	[1]
ADC Info	CN109310885B ADC-3	CN109310885B ADC-3 payload	Undisclosed	CN109310885B ADC-3 linker	[1]
ADC Info	AU2017363246B2 Conjugate53A	AU2017363246B2+Conjugate53+Payload	Undisclosed	AU2017363246B2+Conjugate53+Linker	[13]
ADC Info	AU2017363246B2 Conjugate53B	AU2017363246B2+Conjugate53+Payload	Undisclosed	AU2017363246B2+Conjugate53+Linker	[13]
ADC Info	AU2017363246B2 Conjugate53C	AU2017363246B2+Conjugate53+Payload	Undisclosed	AU2017363246B2+Conjugate53+Linker	[13]
ADC Info	AU2017363246B2 Conjugate53D	AU2017363246B2+Conjugate53+Payload	Undisclosed	AU2017363246B2+Conjugate53+Linker	[13]
ADC Info	AU2017363246B2 Conjugate53E	AU2017363246B2+Conjugate53+Payload	Undisclosed	AU2017363246B2+Conjugate53+Linker	[13]
ADC Info	AU2017363246B2 Conjugate55A	AU2017363246B2+Conjugate55+Payload	Undisclosed	AU2017363246B2+Conjugate55+Linker	[13]
ADC Info	AU2017363246B2 Conjugate55B	AU2017363246B2+Conjugate55+Payload	Undisclosed	AU2017363246B2+Conjugate55+Linker	[13]
ADC Info	AU2017363246B2 Conjugate55C	AU2017363246B2+Conjugate55+Payload	Undisclosed	AU2017363246B2+Conjugate55+Linker	[13]
ADC Info	AU2017363246B2 Conjugate57	AU2017363246B2+Conjugate57+Payload	Undisclosed	AU2017363246B2+Conjugate57+Linker	[13]
ADC Info	AU2017363246B2 Conjugate59	AU2017363246B2+Conjugate59+Payload	Undisclosed	AU2017363246B2+Conjugate59+Linker	[13]
ADC Info	AU2017363246B2 Conjugate61	AU2017363246B2+Conjugate61+Payload	Undisclosed	AU2017363246B2+Conjugate61+Linker	[13]
ADC Info	AU2017363246B2 Conjugate66	AU2017363246B2+Conjugate66+Payload	Undisclosed	AU2017363246B2+Conjugate66+Linker	[13]
ADC Info	AU2017363246B2 Conjugate76	AU2017363246B2+Conjugate76+Payload	Undisclosed	AU2017363246B2+Conjugate76+Linker	[13]
ADC Info	AU2017363246B2 Conjugate78	AU2017363246B2+Conjugate78+Payload	Undisclosed	AU2017363246B2+Conjugate78+Linker	[13]
ADC Info	AU2017363246B2 Conjugate79A	AU2017363246B2+Conjugate79+Payload	Undisclosed	AU2017363246B2+Conjugate79+Linker	[13]
ADC Info	AU2017363246B2 Conjugate79B	AU2017363246B2+Conjugate79+Payload	Undisclosed	AU2017363246B2+Conjugate79+Linker	[13]
ADC Info	AU2017363246B2 Conjugate83	AU2017363246B2+Conjugate83+Payload	Undisclosed	AU2017363246B2+Conjugate83+Linker	[13]
ADC Info	AU2017363246B2 Conjugate85	AU2017363246B2+Conjugate85+Payload	Undisclosed	AU2017363246B2+Conjugate85+Linker	[13]
ADC Info	WO2019126691A1 Conjugate No.20A	Conjugate No.10 Payload	Undisclosed	Conjugate No.5 Linker	[14]
ADC Info	WO2019126691A1 Conjugate No.73A	Conjugate No.67 Payload	Undisclosed	Conjugate No.73 Linker	[14]
ADC Info	WO2019126691A1 Conjugate No.94A	Conjugate No.94 Payload	Undisclosed	Conjugate No.94 Linker	[14]
ADC Info	WO2019126691A1 Conjugate No.135	Conjugate No.135 Payload	Undisclosed	Conjugate No.105 Linker	[14]
ADC Info	WO2019126691A1 Conjugate No.136	Conjugate No.136 Payload	Undisclosed	Conjugate No.105 Linker	[14]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	BSI-715	Undisclosed	Undisclosed	Undisclosed	[15]
ADC Info	Anti-NaPi3b antibody-drug conjugate (Genentech/Roche)	Monomethyl auristatin E	Microtubule (MT)	Undisclosed	[16]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	NaPi2b-STINGa	STINGa	Undisclosed	Undisclosed	[17]
ADC Info	ADRX-0134	AP052	Microtubule (MT)	Undisclosed	[18]

Ref 1	NaPi2b targeting antibody-drug conjugates and methods of use thereof.
Ref 2	Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 3	Quaternary ammonium compounds and their antibody-drug conjugates
Ref 4	Peptidomimetic compounds and antibody-drug conjugates thereof; 2015-09-03.
Ref 5	Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 6	1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 7	ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload. Cancer Res (2023) 83 (7_Supplement): 1533.
Ref 8	Anti-SLC34A2 antibodies, antibody-drug conjugates and methods of use
Ref 9	Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.
Ref 10	Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.
Ref 11	Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 12	Peptide-containing linkers for antibody-drug conjugates.
Ref 13	Peptide-containing linkers for antibody-drug conjugates
Ref 14	Pyrrolobenzodiazepine antibody conjugates
Ref 15	Introduction to basic information on ADC drug BSI-715.
Ref 16	Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. Ann Oncol. 2018 Apr 1;29(4):917-923.
Ref 17	Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses
Ref 18	ADRX-0134 as a novel auristatin-based NaPi2b antibody-drug conjugate with widened therapeutic window