General Information of This Antigen
Antigen ID
TAR0AABNG
Antigen Name
Sodium-dependent phosphate transport protein 2B (SLC34A2)
Gene Name
SLC34A2
Gene ID
10568
Synonym
Na(+)-dependent phosphate cotransporter 2B;NaPi3b;Sodium/phosphate cotransporter 2B;Solute carrier family 34 member 2
Sequence
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLI
DEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSS
AFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRA
AIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHY
LEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVK
IWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLP
DLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAI
LVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNA
LRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLI
PLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSL
KPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVK
APETFDNITISREAQGEVPASDSKTECTAL

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Family
SEZ6 family
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport.

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Uniprot Entry
NPT2B_HUMAN
HGNC ID
HGNC:11020
KEGG ID
hsa:10568
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
10H1.11.4B
ADC Info ADC Name Payload Target Linker Ref
CN109310885B ADC-4
CN109310885B ADC-4 payload
Undisclosed
CN109310885B ADC-4 linker
[1]
CN109310885B ADC-5
CN109310885B ADC-5 payload
Undisclosed
CN109310885B ADC-5 linker
[1]
CN109310885B ADC-6
CN109310885B ADC-6 payload
Undisclosed
CN109310885B ADC-6 linker
[1]
CN109310885B ADC-9
CN109310885B ADC-9 payload
Undisclosed
CN109310885B ADC-9 linker
[1]
CN109310885B ADC-10
CN109310885B ADC-10 payload
Undisclosed
CN109310885B ADC-10 linker
[1]
Anti-NaPi2b mAb 10H1.11.4B
ADC Info ADC Name Payload Target Linker Ref
NaPi2b PNU ADC3-1
NaPi2b PNU ADC3-1 payload
Undisclosed
NaPi2b PNU ADC3-1 linker
[2]
NaPi2b PNU ADC4-1
NaPi2b PNU ADC4-1 payload
Undisclosed
NaPi2b PNU ADC4-1 linker
[2]
NaPi2b-PNU-LD1
NaPi2b-PNU-LD1 payload
Undisclosed
NaPi2b-PNU-LD1 linker
[2]
NaPi2b-PNU-LD2
NaPi2b-PNU-LD2 payload
Undisclosed
NaPi2b-PNU-LD2 linker
[2]
NaPi2b-PNU-LD5
NaPi2b-PNU-LD5 payload
Undisclosed
NaPi2b-PNU-LD5 linker
[2]
NaPi2b-PNU-LD6
NaPi2b-PNU-LD6 payload
Undisclosed
NaPi2b-PNU-LD6 linker
[2]
NaPi2b-PNU-LD7
NaPi2b-PNU-LD7 payload
Undisclosed
NaPi2b-PNU-LD7 linker
[2]
Anti-NaPi2b-LC-K149C
ADC Info ADC Name Payload Target Linker Ref
Alpha-NaPi2b-LC-K149C-10
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 10
[3]
Alpha-NaPi2b-LC-K149C-11
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2
[3]
CN105828840B_ADC-134 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-134
CN105828840B_ADC-134 payload
Undisclosed
CN105828840B_ADC-134 linker
[4]
CN105828840B_ADC-135 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-135
CN105828840B_ADC-135 payload
Undisclosed
CN105828840B_ADC-135 linker
[4]
CN105828840B_ADC-136 antibody
ADC Info ADC Name Payload Target Linker Ref
CN105828840B ADC-136
CN105828840B_ADC-136 payload
Undisclosed
CN105828840B_ADC-136 linker
[4]
Fully humanized Anti-SLC34A2 IgG1 mAb
ADC Info ADC Name Payload Target Linker Ref
ZW-220
ZD06519
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly-AM
[5]
Lifastuzumab
ADC Info ADC Name Payload Target Linker Ref
Lifastuzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[6]
Thio Anti-Napi2B 10H1.11.4B LC V205C
ADC Info ADC Name Payload Target Linker Ref
WO2017214024A1 ADC-102
WO2017214024A1_ADC-102 payload
Undisclosed
WO2017214024A1_ADC-102 linker
[7]
Thio hu Anti-NaPi2b 10H1.11.4B LC K149C
ADC Info ADC Name Payload Target Linker Ref
WO2017059289A1 ADC-208
WO2017059289A1_ADC-208 payload
Undisclosed
WO2017059289A1_ADC-208 linker
[8]
Thio hu Anti-Napi3b 10H1.11.4B HC A118C
ADC Info ADC Name Payload Target Linker Ref
WO2014159981A2 ADC-205
WO2014159981A2_ADC-205 payload
Undisclosed
WO2014159981A2_ADC-205 linker
[9]
WO2014159981A2 ADC-SLC34A2-33
WO2014159981A2_ADC-SLC34A2-33 payload
Undisclosed
WO2014159981A2_ADC-SLC34A2-33 linker
[9]
WO2014159981A2 ADC-SLC34A2-37
WO2014159981A2_ADC-SLC34A2-37 payload
Undisclosed
WO2014159981A2_ADC-SLC34A2-37 linker
[9]
ADC Info ADC Name Payload Target Linker Ref
Upifitamab rilsodotin
Auristatin F hydroxypropylamide (AF-HPA)
Microtubule (MT)
Dolaflexin polymer
[10]
WO2018098269A2 conjugate 53A
WO2018098269A2_conjugate 53A payload
Undisclosed
WO2018098269A2_conjugate 53A linker
[11]
WO2018098269A2 conjugate 55A
WO2018098269A2_conjugate 55A payload
Undisclosed
WO2018098269A2_conjugate 55A linker
[11]
WO2018098269A2 conjugate 57
WO2018098269A2_conjugate 57 payload
Undisclosed
WO2018098269A2_conjugate 57 linker
[11]
WO2018098269A2 conjugate 59
WO2018098269A2_conjugate 59 payload
Undisclosed
WO2018098269A2_conjugate 59 linker
[11]
WO2018098269A2 conjugate 61
WO2018098269A2_conjugate 61 payload
Undisclosed
WO2018098269A2_conjugate 61 linker
[11]
WO2018098269A2 conjugate 66
WO2018098269A2_conjugate 66 payload
Undisclosed
WO2018098269A2_conjugate 66 linker
[11]
WO2018098269A2 conjugate 79A
WO2018098269A2_conjugate 79A payload
Undisclosed
WO2018098269A2_conjugate 79A linker
[11]
WO2018098269A2 conjugate 76
WO2018098269A2_conjugate 76 payload
Undisclosed
WO2018098269A2_conjugate 76 linker
[11]
WO2018098269A2 conjugate 83
WO2018098269A2_conjugate 83 payload
Undisclosed
WO2018098269A2_conjugate 83 linker
[11]
WO2018098269A2 conjugate 78
WO2018098269A2_conjugate 78 payload
Undisclosed
WO2018098269A2_conjugate 78 linker
[11]
WO2018098269A2 conjugate 85
WO2018098269A2_conjugate 85 payload
Undisclosed
WO2018098269A2_conjugate 85 linker
[11]
WO2018098269A2 conjugate 53B
WO2018098269A2_conjugate 53B payload
Undisclosed
WO2018098269A2_conjugate 53B linker
[11]
WO2018098269A2 conjugate 53C
WO2018098269A2_conjugate 53C payload
Undisclosed
WO2018098269A2_conjugate 53C linker
[11]
WO2018098269A2 conjugate 53D
WO2018098269A2_conjugate 53D payload
Undisclosed
WO2018098269A2_conjugate 53D linker
[11]
WO2018098269A2 conjugate 53E
WO2018098269A2_conjugate 53E payload
Undisclosed
WO2018098269A2_conjugate 53E linker
[11]
WO2018098269A2 conjugate 55B
WO2018098269A2_conjugate 55B payload
Undisclosed
WO2018098269A2_conjugate 55B linker
[11]
WO2018098269A2 conjugate 79B
WO2018098269A2_conjugate 79B payload
Undisclosed
WO2018098269A2_conjugate 79B linker
[11]
CN109310885B ADC-1
CN109310885B ADC-1 payload
Undisclosed
CN109310885B ADC-1 linker
[1]
CN109310885B ADC-2
CN109310885B ADC-2 payload
Undisclosed
CN109310885B ADC-2 linker
[1]
CN109310885B ADC-3
CN109310885B ADC-3 payload
Undisclosed
CN109310885B ADC-3 linker
[1]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
XMT-1592
Auristatin F hydroxypropylamide (AF-HPA)
Microtubule (MT)
Cys-13 ADC linker
[12]
BSI-715
Undisclosed
Undisclosed
Undisclosed
[13]
Anti-NaPi3b antibody-drug conjugate (Genentech/Roche)
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[14]
Tissue/Disease specific Abundances of This Antigen
Tissue specific Abundances of This Antigen
ICD Disease Classification 01
Click to Show/Hide the 1 Disease of This Class
Bacterial infection [ICD-11: 1A00-1C4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.330243367; Fold-change: 0.027363025; Z-score: 0.142733964
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 02
Click to Show/Hide the 22 Disease of This Class
Brain cancer [ICD-11: 2A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Brainstem
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.63902292; Fold-change: -0.027818332; Z-score: -1.383167705
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.45783172; Fold-change: -0.290701376; Z-score: -0.881628818
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem
The Specific Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.106223097; Fold-change: -0.176864527; Z-score: -1.047801379
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Nervous
The Specific Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 3.14E-21; Fold-change: 0.112726927; Z-score: 0.53830518
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic myeloid leukemia [ICD-11: 2A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.32125349; Fold-change: 0.049701756; Z-score: 0.415642565
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Whole blood
The Specific Disease Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.171630771; Fold-change: 0.098295308; Z-score: 0.836329149
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
MyeloDysplastic syndromes [ICD-11: 2A37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.003863287; Fold-change: 0.095782899; Z-score: 0.864754115
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.864365639; Fold-change: -0.020206453; Z-score: -0.178659164
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lymphoma [ICD-11: 2A90- 2A85]
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Differential expression pattern of antigen in diseases
The Studied Tissue Tonsil
The Specific Disease Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.529151048; Fold-change: -0.055596927; Z-score: -0.22719282
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Gastric cancer [ICD-11: 2B72]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric
The Specific Disease Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000109413; Fold-change: 0.25736855; Z-score: 5.270474676
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000415767; Fold-change: 0.074725411; Z-score: 0.332396516
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Colon cancer [ICD-11: 2B90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon
The Specific Disease Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.725940372; Fold-change: -0.009996794; Z-score: -0.053014789
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.398221494; Fold-change: -0.023035204; Z-score: -0.108606194
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pancreatic cancer [ICD-11: 2C10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pancreas
The Specific Disease Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.999410244; Fold-change: 0.062215107; Z-score: 0.061169598
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000193983; Fold-change: 0.474328577; Z-score: 0.84694959
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver cancer [ICD-11: 2C12]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.453302985; Fold-change: -0.038892415; Z-score: -0.155951832
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.64E-17; Fold-change: -0.320671701; Z-score: -1.058537622
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.423209734; Fold-change: 0.076603615; Z-score: 0.353820853
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lung cancer [ICD-11: 2C25]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 3.17E-60; Fold-change: -0.924680721; Z-score: -1.502679789
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 3.56E-39; Fold-change: -0.902191718; Z-score: -1.185418337
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Melanoma [ICD-11: 2C30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.033324945; Fold-change: -0.561260565; Z-score: -0.533247995
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sarcoma [ICD-11: 2C35]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.004884084; Fold-change: -0.032944816; Z-score: -0.193451934
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.539306635; Fold-change: -0.076315793; Z-score: -0.675496842
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Breast cancer [ICD-11: 2C60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Breast
The Specific Disease Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.73E-23; Fold-change: -0.911463459; Z-score: -1.071539413
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 9.16E-05; Fold-change: -0.758627639; Z-score: -0.731351566
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ovarian cancer [ICD-11: 2C73]
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Differential expression pattern of antigen in diseases
The Studied Tissue Ovarian
The Specific Disease Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000252513; Fold-change: 3.585892004; Z-score: 2.614444631
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 6.89E-05; Fold-change: 3.079569612; Z-score: 1.820907085
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cervical cancer [ICD-11: 2C77]
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Differential expression pattern of antigen in diseases
The Studied Tissue Cervical
The Specific Disease Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.984146868; Fold-change: 0.14386004; Z-score: 0.104713653
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Uterine cancer [ICD-11: 2C78]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.87E-09; Fold-change: -1.262990765; Z-score: -0.767880818
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 4.41E-18; Fold-change: 2.820195819; Z-score: 15.62792951
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Prostate cancer [ICD-11: 2C82]
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Differential expression pattern of antigen in diseases
The Studied Tissue Prostate
The Specific Disease Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.164638748; Fold-change: -0.383940288; Z-score: -0.334867609
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Bladder cancer [ICD-11: 2C94]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000183668; Fold-change: 0.515590765; Z-score: 2.260742679
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Retina cancer [ICD-11: 2D02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Uvea
The Specific Disease Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.890950718; Fold-change: 0.003433614; Z-score: 0.046074748
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thyroid cancer [ICD-11: 2D10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Thyroid
The Specific Disease Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.55E-53; Fold-change: 3.500705941; Z-score: 5.430210429
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 7.34E-13; Fold-change: 3.207566416; Z-score: 2.440300657
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Adrenal cancer [ICD-11: 2D11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adrenal cortex
The Specific Disease Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.129064182; Fold-change: 0.002357132; Z-score: 0.033671192
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Head and neck cancer [ICD-11: 2D42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Head and neck
The Specific Disease Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.47E-12; Fold-change: -0.673135038; Z-score: -0.397962606
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pituitary cancer [ICD-11: 2F37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pituitary
The Specific Disease Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.163208845; Fold-change: -0.260100331; Z-score: -0.19260112
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Pituitary
The Specific Disease Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.129943865; Fold-change: -0.094404486; Z-score: -0.082634588
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 03
Click to Show/Hide the 1 Disease of This Class
Thrombocytopenia [ICD-11: 3B64]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.713800112; Fold-change: -0.137757287; Z-score: -1.480584459
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 04
Click to Show/Hide the 2 Disease of This Class
Lupus erythematosus [ICD-11: 4A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.257642731; Fold-change: -0.023272831; Z-score: -0.076692965
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autoimmune disease [ICD-11: 4A4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral monocyte
The Specific Disease Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.681003779; Fold-change: -0.008771579; Z-score: -0.076531085
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 05
Click to Show/Hide the 1 Disease of This Class
Hyperlipoproteinaemia [ICD-11: 5C80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.940319193; Fold-change: 0.062309563; Z-score: 0.541784796
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 06
Click to Show/Hide the 1 Disease of This Class
Schizophrenia [ICD-11: 6A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Superior temporal cortex
The Specific Disease Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.43531226; Fold-change: 0.016995859; Z-score: 0.150869536
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 08
Click to Show/Hide the 3 Disease of This Class
Multiple sclerosis [ICD-11: 8A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Spinal cord
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.691026172; Fold-change: 0.00736888; Z-score: 0.041041837
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Plasmacytoid dendritic cells
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.147768034; Fold-change: 0.155538066; Z-score: 0.769519502
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Epilepsy [ICD-11: 8A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peritumoral cortex
The Specific Disease Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.546713009; Fold-change: 0.019557443; Z-score: 0.093811085
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cerebral ischaemic stroke [ICD-11: 8B11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000543151; Fold-change: 0.136541808; Z-score: 1.027661233
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.585101023; Fold-change: -0.014066242; Z-score: -0.113468598
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 1
Click to Show/Hide the 6 Disease of This Class
HIV [ICD-11: 1C60-1C62]
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Differential expression pattern of antigen in diseases
The Studied Tissue White matter
The Specific Disease HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.189150662; Fold-change: -0.021177265; Z-score: -0.069607541
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Influenza [ICD-11: 1E30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.322770537; Fold-change: 0.209821606; Z-score: 1.240858436
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic hepatitis C [ICD-11: 1E51.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.621975674; Fold-change: 0.034759135; Z-score: 0.159008894
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sepsis [ICD-11: 1G40-1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.530925172; Fold-change: -0.033461766; Z-score: -0.24936729
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Septic shock [ICD-11: 1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.888918556; Fold-change: -0.031287984; Z-score: -0.197265016
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pediatric respiratory syncytial virus infection [ICD-11: CA40.11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.746793043; Fold-change: -0.049284112; Z-score: -0.486276874
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 11
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Essential hypertension [ICD-11: BA00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.216022927; Fold-change: -0.192291774; Z-score: -3.964162525
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myocardial infarction [ICD-11: BA41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.19569741; Fold-change: -0.007994312; Z-score: -0.018052366
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Coronary artery disease [ICD-11: BA8Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.440053924; Fold-change: -0.116658498; Z-score: -0.636107484
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aortic stenosis [ICD-11: BB70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Calcified aortic valve
The Specific Disease Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.536997881; Fold-change: -0.010367892; Z-score: -0.064799635
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arteriosclerosis [ICD-11: BD40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.890715996; Fold-change: -0.000637447; Z-score: -0.006055544
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aneurysm [ICD-11: BD50]
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Differential expression pattern of antigen in diseases
The Studied Tissue Intracranial artery
The Specific Disease Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.309724792; Fold-change: 0.036165268; Z-score: 0.043123516
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 12
Click to Show/Hide the 8 Disease of This Class
Immunodeficiency [ICD-11: 4A00-4A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.918188955; Fold-change: -0.035321271; Z-score: -0.401037641
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Apnea [ICD-11: 7A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Hyperplastic tonsil
The Specific Disease Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.506646838; Fold-change: 0.04406933; Z-score: 0.183928145
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Olive pollen allergy [ICD-11: CA08.00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.599273155; Fold-change: -0.001049413; Z-score: -0.004971043
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic rhinosinusitis [ICD-11: CA0A]
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Differential expression pattern of antigen in diseases
The Studied Tissue Sinus mucosa
The Specific Disease Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.030677455; Fold-change: 2.303488973; Z-score: 4.581289432
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic obstructive pulmonary disease [ICD-11: CA22]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.033149838; Fold-change: -0.238960929; Z-score: -0.398235148
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Small airway epithelium
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.144621822; Fold-change: -0.219427711; Z-score: -0.307452269
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Asthma [ICD-11: CA23]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal and bronchial airway
The Specific Disease Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000210833; Fold-change: -2.210117466; Z-score: -1.037802983
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Human rhinovirus infection [ICD-11: CA42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal Epithelium
The Specific Disease Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.861219023; Fold-change: -0.174022413; Z-score: -0.326437701
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.925005444; Fold-change: -0.13509276; Z-score: -0.197170975
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 13
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Periodontal disease [ICD-11: DA0C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.20177116; Fold-change: 0.041910115; Z-score: 0.223946991
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Eosinophilic gastritis [ICD-11: DA42.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric antrum
The Specific Disease Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.072050436; Fold-change: -0.129054293; Z-score: -1.091696673
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver failure [ICD-11: DB99.7-DB99.8]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.37143275; Fold-change: 0.168654765; Z-score: 0.86079855
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ulcerative colitis [ICD-11: DD71]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon mucosal
The Specific Disease Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.024342562; Fold-change: -0.220337439; Z-score: -0.874712498
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Irritable bowel syndrome [ICD-11: DD91.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.558772868; Fold-change: 0.062669581; Z-score: 0.165448638
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 14
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Atopic dermatitis [ICD-11: EA80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.96E-06; Fold-change: 0.388959152; Z-score: 1.820083821
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Psoriasis [ICD-11: EA90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.011823318; Fold-change: -0.200934447; Z-score: -0.3592176
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 3.70E-12; Fold-change: -0.77253655; Z-score: -1.006485826
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Vitiligo [ICD-11: ED63.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.738826449; Fold-change: -0.225100449; Z-score: -0.221206389
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alopecia [ICD-11: ED70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin from scalp
The Specific Disease Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.418258918; Fold-change: 0.033435995; Z-score: 0.048695121
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sensitive skin [ICD-11: EK0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.013894185; Fold-change: -0.259216776; Z-score: -1.453290277
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 15
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Osteoarthritis [ICD-11: FA00-FA0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.863098401; Fold-change: 0.037059857; Z-score: 0.188951726
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthropathy [ICD-11: FA00-FA5Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.339559782; Fold-change: -0.017438096; Z-score: -0.159863798
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.708280658; Fold-change: 0.023165878; Z-score: 0.057974481
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rheumatoid arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.407597597; Fold-change: -0.023504246; Z-score: -0.102365738
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ankylosing spondylitis [ICD-11: FA92.0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pheripheral blood
The Specific Disease Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.827812277; Fold-change: -0.046612062; Z-score: -0.330682849
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Osteoporosis [ICD-11: FB83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.177875026; Fold-change: 0.161499276; Z-score: 1.216284144
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 16
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Endometriosis [ICD-11: GA10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.72545033; Fold-change: -0.051017223; Z-score: -0.023001698
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Interstitial cystitis [ICD-11: GC00.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.764966004; Fold-change: 0.065664643; Z-score: 0.822685731
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 19
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Preterm birth [ICD-11: KA21.4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Myometrium
The Specific Disease Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.380558148; Fold-change: -0.336398065; Z-score: -0.564831807
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 2
Click to Show/Hide the 8 Disease of This Class
Acute myelocytic leukemia [ICD-11: 2A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.085104095; Fold-change: -0.029756015; Z-score: -0.225340817
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myeloma [ICD-11: 2A83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.013524309; Fold-change: -0.258665799; Z-score: -1.430998025
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.962660174; Fold-change: 0.024688879; Z-score: 0.172728306
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Oral cancer [ICD-11: 2B6E]
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Differential expression pattern of antigen in diseases
The Studied Tissue Oral
The Specific Disease Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.113587185; Fold-change: -0.123329756; Z-score: -0.237261261
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.006810004; Fold-change: 0.093850137; Z-score: 0.275613083
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Esophagal cancer [ICD-11: 2B70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Esophagus
The Specific Disease Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.943720474; Fold-change: -0.100884511; Z-score: -0.618432166
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rectal cancer [ICD-11: 2B92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.070030077; Fold-change: -0.134706609; Z-score: -0.920716279
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.168485451; Fold-change: 0.069280813; Z-score: 0.484870837
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Skin cancer [ICD-11: 2C30-2C3Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.04E-21; Fold-change: -0.371667936; Z-score: -0.518473153
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 3.88E-40; Fold-change: -1.122091758; Z-score: -1.188455331
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Renal cancer [ICD-11: 2C90-2C91]
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Differential expression pattern of antigen in diseases
The Studied Tissue Kidney
The Specific Disease Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.889119713; Fold-change: -0.075827592; Z-score: -0.073894361
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.304839718; Fold-change: -0.449521768; Z-score: -0.556830297
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ureter cancer [ICD-11: 2C92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Urothelium
The Specific Disease Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.046641028; Fold-change: -0.089729537; Z-score: -0.882905683
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 20
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Simpson golabi behmel syndrome [ICD-11: LD2C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adipose
The Specific Disease Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.108155668; Fold-change: -0.163142988; Z-score: -2.210241813
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Tuberous sclerosis complex [ICD-11: LD2D.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Perituberal
The Specific Disease Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.008859299; Fold-change: 0.315261587; Z-score: 3.413161206
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 3
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Anemia [ICD-11: 3A00-3A9Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.124361881; Fold-change: 0.117714973; Z-score: 0.585266007
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sickle cell disease [ICD-11: 3A51.0-3A51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.017864122; Fold-change: 0.138803971; Z-score: 1.050797707
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thrombocythemia [ICD-11: 3B63]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.401227598; Fold-change: -0.001187209; Z-score: -0.010305973
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 4
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Scleroderma [ICD-11: 4A42.Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.75E-05; Fold-change: 0.172783418; Z-score: 2.202618971
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sjogren syndrome [ICD-11: 4A43]
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Differential expression pattern of antigen in diseases
The Studied Tissue Salivary gland
The Specific Disease Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.033217254; Fold-change: 0.264835525; Z-score: 1.066773381
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.189246231; Fold-change: -0.54139692; Z-score: -0.988681741
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Behcet disease [ICD-11: 4A62]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.499011595; Fold-change: 0.130761057; Z-score: 0.540827522
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autosomal dominant monocytopenia [ICD-11: 4B04]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.271044918; Fold-change: -0.034215769; Z-score: -0.280720832
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 5
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Type 2 diabetes [ICD-11: 5A11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.985338043; Fold-change: 0.027138608; Z-score: 0.068541834
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Polycystic ovary syndrome [ICD-11: 5A80.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Vastus lateralis muscle
The Specific Disease Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.994727632; Fold-change: 0.003863907; Z-score: 0.024078567
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Obesity [ICD-11: 5B81]
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Differential expression pattern of antigen in diseases
The Studied Tissue Subcutaneous Adipose
The Specific Disease Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.369986944; Fold-change: -0.021599273; Z-score: -0.142398127
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pompe disease [ICD-11: 5C51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Biceps muscle
The Specific Disease Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.664191997; Fold-change: -0.10179519; Z-score: -0.448428519
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Batten disease [ICD-11: 5C56.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.664475252; Fold-change: -0.029882142; Z-score: -0.263606565
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 6
Click to Show/Hide the 2 Disease of This Class
Autism [ICD-11: 6A02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.54855365; Fold-change: 0.020271053; Z-score: 0.134734756
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Anxiety disorder [ICD-11: 6B00-6B0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.354606516; Fold-change: -0.025081918; Z-score: -0.12463661
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 8
Click to Show/Hide the 7 Disease of This Class
Parkinson disease [ICD-11: 8A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Substantia nigra
The Specific Disease Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.826246122; Fold-change: -0.014845302; Z-score: -0.168087436
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Huntington disease [ICD-11: 8A01]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.291060792; Fold-change: 0.021272007; Z-score: 0.30931237
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alzheimer disease [ICD-11: 8A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Entorhinal cortex
The Specific Disease Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.77566996; Fold-change: 0.010641982; Z-score: 0.075273997
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Seizure [ICD-11: 8A60-8A6Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.036135887; Fold-change: -0.076033202; Z-score: -0.461082642
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lateral sclerosis [ICD-11: 8B60.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.218924068; Fold-change: -0.004325345; Z-score: -0.071427062
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Cervical spinal cord
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.849557623; Fold-change: -0.016419999; Z-score: -0.075375484
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Muscular atrophy [ICD-11: 8C70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.342463052; Fold-change: 0.060328394; Z-score: 0.4277928
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myopathy [ICD-11: 8C70.6]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.085663535; Fold-change: 0.106447307; Z-score: 1.033366118
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
References
Ref 1 NaPi2b targeting antibody-drug conjugates and methods of use thereof.
Ref 2 Peptidomimetic compounds and antibody-drug conjugates thereof; 2015-09-03.
Ref 3 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 4 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 5 ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload. Cancer Res (2023) 83 (7_Supplement): 1533.
Ref 6 Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer. Clin Cancer Res. 2020 Jan 15;26(2):364-372.
Ref 7 Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.
Ref 8 Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.
Ref 9 Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 10 The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b. Mol Cancer Ther. 2021 May;20(5):896-905.
Ref 11 Peptide-containing linkers for antibody-drug conjugates.
Ref 12 XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma. Cancer Res (2020) 80 (16_Supplement): 2894.
Ref 13 Introduction to basic information on ADC drug BSI-715.
Ref 14 Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. Ann Oncol. 2018 Apr 1;29(4):917-923.

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