Antigen Information

General Information of This Antigen (ID: TAR0AABNG)
Antigen Name
Sodium-dependent phosphate transport protein 2B (SLC34A2)
Gene Name
SLC34A2
Gene ID
10568
Synonym
Na(+)-dependent phosphate cotransporter 2B;NaPi3b;Sodium/phosphate cotransporter 2B;Solute carrier family 34 member 2
Sequence
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLI
DEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSS
AFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRA
AIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHY
LEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVK
IWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLP
DLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAI
LVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNA
LRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLI
PLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSL
KPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVK
APETFDNITISREAQGEVPASDSKTECTAL

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Family
SEZ6 family
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport.

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Uniprot Entry
NPT2B_HUMAN
HGNC ID
HGNC:11020
KEGG ID
hsa:10568
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
10H1.11.4B
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN109310885B ADC-4 [1]
CN109310885B ADC-4 payload
Undisclosed
CN109310885B ADC-4 linker
 ADC Info 
CN109310885B ADC-5 [1]
CN109310885B ADC-5 payload
Undisclosed
CN109310885B ADC-5 linker
 ADC Info 
CN109310885B ADC-6 [1]
CN109310885B ADC-6 payload
Undisclosed
CN109310885B ADC-6 linker
 ADC Info 
CN109310885B ADC-9 [1]
CN109310885B ADC-9 payload
Undisclosed
CN109310885B ADC-9 linker
 ADC Info 
CN109310885B ADC-10 [1]
CN109310885B ADC-10 payload
Undisclosed
CN109310885B ADC-10 linker
 ADC Info 
10H1.11.4B LC A149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-121 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-123 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-125 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-127 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN107206101B ADC-1 [3]
Dolastatin10
Undisclosed
MC-Sq-CIt-PAB
 ADC Info 
CN107206101B ADC-2-1 [3]
Tubulysin M
Undisclosed
MC-Sq-CIt-PAB
 ADC Info 
Anti- Napi2b Disulfide-Tubulysin M [3]
Tubulysin M
Undisclosed
Disulfide linker
 ADC Info 
10H1.11B HC A118C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-106 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-113 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
Anti-NaPi-2b antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
XMT-1592
AF-HPA
Microtubule (MT)
Cys-13 ADC linker
 ADC Info 
Anti-Napi2b Fc-silenced IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TUB-040
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG24)-Val-Cit-PABC
 ADC Info 
Anti-NaPi2b mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
YL205
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
Anti-NaPi2b mAb 10H1.11.4B
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NaPi2b PNU ADC3-1 [4]
NaPi2b PNU ADC3-1 payload
Undisclosed
NaPi2b PNU ADC3-1 linker
 ADC Info 
NaPi2b PNU ADC4-1 [4]
NaPi2b PNU ADC4-1 payload
Undisclosed
NaPi2b PNU ADC4-1 linker
 ADC Info 
NaPi2b-PNU-LD1 [4]
NaPi2b-PNU-LD1 payload
Undisclosed
NaPi2b-PNU-LD1 linker
 ADC Info 
NaPi2b-PNU-LD2 [4]
NaPi2b-PNU-LD2 payload
Undisclosed
NaPi2b-PNU-LD2 linker
 ADC Info 
NaPi2b-PNU-LD5 [4]
NaPi2b-PNU-LD5 payload
Undisclosed
NaPi2b-PNU-LD5 linker
 ADC Info 
NaPi2b-PNU-LD6 [4]
NaPi2b-PNU-LD6 payload
Undisclosed
NaPi2b-PNU-LD6 linker
 ADC Info 
NaPi2b-PNU-LD7 [4]
NaPi2b-PNU-LD7 payload
Undisclosed
NaPi2b-PNU-LD7 linker
 ADC Info 
Anti-NaPi2b-LC-K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-NaPi2b-LC-K149C-10 [5]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 10
 ADC Info 
Alpha-NaPi2b-LC-K149C-11 [5]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2
 ADC Info 
CN105828840B_ADC-134 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-134 [6]
CN105828840B_ADC-134 payload
Undisclosed
CN105828840B_ADC-134 linker
 ADC Info 
CN105828840B_ADC-135 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-135 [6]
CN105828840B_ADC-135 payload
Undisclosed
CN105828840B_ADC-135 linker
 ADC Info 
CN105828840B_ADC-136 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-136 [6]
CN105828840B_ADC-136 payload
Undisclosed
CN105828840B_ADC-136 linker
 ADC Info 
Fully humanized Anti-SLC34A2 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZW-220 [7]
ZD06519
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly-AM
 ADC Info 
Lifastuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Lifastuzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
OT1:cHv83-1b15.G1 (L328C)k
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AGL-01332-93 (BrAc) 2.43 [8]
CN114929286A 93
Undisclosed
AGL-01332 linker
 ADC Info 
AGL-01332-93CI 2.19 [8]
CN114929286A 93CI
Undisclosed
AGL-01332 linker
 ADC Info 
OT1:cHv83-3a23.G1 (L328C)k
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AGL-01332-93 (BrAc) 1.98 [8]
CN114929286A 93
Undisclosed
AGL-01332 linker
 ADC Info 
AGL-01332-93CI 1.82 [8]
CN114929286A 93CI
Undisclosed
AGL-01332 linker
 ADC Info 
Thio Anti-Napi2B 10H1.11.4B LC V205C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017214024A1 ADC-102 [9]
WO2017214024A1_ADC-102 payload
Undisclosed
WO2017214024A1_ADC-102 linker
 ADC Info 
Thio hu Anti-NaPi2b 10H1.11.4B LC K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-208 [10]
WO2017059289A1_ADC-208 payload
Undisclosed
WO2017059289A1_ADC-208 linker
 ADC Info 
Thio hu Anti-Napi3b 10H1.11.4B HC A118C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2014159981A2 ADC-205 [11]
WO2014159981A2_ADC-205 payload
Undisclosed
WO2014159981A2_ADC-205 linker
 ADC Info 
WO2014159981A2 ADC-SLC34A2-33 [11]
WO2014159981A2_ADC-SLC34A2-33 payload
Undisclosed
WO2014159981A2_ADC-SLC34A2-33 linker
 ADC Info 
WO2014159981A2 ADC-SLC34A2-37 [11]
WO2014159981A2_ADC-SLC34A2-37 payload
Undisclosed
WO2014159981A2_ADC-SLC34A2-37 linker
 ADC Info 
Upifitamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Upifitamab rilsodotin
AF-HPA
Microtubule (MT)
Dolaflexin polymer
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2018098269A2 conjugate 53A [12]
WO2018098269A2_conjugate 53A payload
Undisclosed
WO2018098269A2_conjugate 53A linker
 ADC Info 
WO2018098269A2 conjugate 55A [12]
WO2018098269A2_conjugate 55A payload
Undisclosed
WO2018098269A2_conjugate 55A linker
 ADC Info 
WO2018098269A2 conjugate 57 [12]
WO2018098269A2_conjugate 57 payload
Undisclosed
WO2018098269A2_conjugate 57 linker
 ADC Info 
WO2018098269A2 conjugate 59 [12]
WO2018098269A2_conjugate 59 payload
Undisclosed
WO2018098269A2_conjugate 59 linker
 ADC Info 
WO2018098269A2 conjugate 61 [12]
WO2018098269A2_conjugate 61 payload
Undisclosed
WO2018098269A2_conjugate 61 linker
 ADC Info 
WO2018098269A2 conjugate 66 [12]
WO2018098269A2_conjugate 66 payload
Undisclosed
WO2018098269A2_conjugate 66 linker
 ADC Info 
WO2018098269A2 conjugate 79A [12]
WO2018098269A2_conjugate 79A payload
Undisclosed
WO2018098269A2_conjugate 79A linker
 ADC Info 
WO2018098269A2 conjugate 76 [12]
WO2018098269A2_conjugate 76 payload
Undisclosed
WO2018098269A2_conjugate 76 linker
 ADC Info 
WO2018098269A2 conjugate 83 [12]
WO2018098269A2_conjugate 83 payload
Undisclosed
WO2018098269A2_conjugate 83 linker
 ADC Info 
WO2018098269A2 conjugate 78 [12]
WO2018098269A2_conjugate 78 payload
Undisclosed
WO2018098269A2_conjugate 78 linker
 ADC Info 
WO2018098269A2 conjugate 85 [12]
WO2018098269A2_conjugate 85 payload
Undisclosed
WO2018098269A2_conjugate 85 linker
 ADC Info 
WO2018098269A2 conjugate 53B [12]
WO2018098269A2_conjugate 53B payload
Undisclosed
WO2018098269A2_conjugate 53B linker
 ADC Info 
WO2018098269A2 conjugate 53C [12]
WO2018098269A2_conjugate 53C payload
Undisclosed
WO2018098269A2_conjugate 53C linker
 ADC Info 
WO2018098269A2 conjugate 53D [12]
WO2018098269A2_conjugate 53D payload
Undisclosed
WO2018098269A2_conjugate 53D linker
 ADC Info 
WO2018098269A2 conjugate 53E [12]
WO2018098269A2_conjugate 53E payload
Undisclosed
WO2018098269A2_conjugate 53E linker
 ADC Info 
WO2018098269A2 conjugate 55B [12]
WO2018098269A2_conjugate 55B payload
Undisclosed
WO2018098269A2_conjugate 55B linker
 ADC Info 
WO2018098269A2 conjugate 79B [12]
WO2018098269A2_conjugate 79B payload
Undisclosed
WO2018098269A2_conjugate 79B linker
 ADC Info 
CN109310885B ADC-1 [1]
CN109310885B ADC-1 payload
Undisclosed
CN109310885B ADC-1 linker
 ADC Info 
CN109310885B ADC-2 [1]
CN109310885B ADC-2 payload
Undisclosed
CN109310885B ADC-2 linker
 ADC Info 
CN109310885B ADC-3 [1]
CN109310885B ADC-3 payload
Undisclosed
CN109310885B ADC-3 linker
 ADC Info 
AU2017363246B2 Conjugate53A [13]
AU2017363246B2+Conjugate53+Payload
Undisclosed
AU2017363246B2+Conjugate53+Linker
 ADC Info 
AU2017363246B2 Conjugate53B [13]
AU2017363246B2+Conjugate53+Payload
Undisclosed
AU2017363246B2+Conjugate53+Linker
 ADC Info 
AU2017363246B2 Conjugate53C [13]
AU2017363246B2+Conjugate53+Payload
Undisclosed
AU2017363246B2+Conjugate53+Linker
 ADC Info 
AU2017363246B2 Conjugate53D [13]
AU2017363246B2+Conjugate53+Payload
Undisclosed
AU2017363246B2+Conjugate53+Linker
 ADC Info 
AU2017363246B2 Conjugate53E [13]
AU2017363246B2+Conjugate53+Payload
Undisclosed
AU2017363246B2+Conjugate53+Linker
 ADC Info 
AU2017363246B2 Conjugate55A [13]
AU2017363246B2+Conjugate55+Payload
Undisclosed
AU2017363246B2+Conjugate55+Linker
 ADC Info 
AU2017363246B2 Conjugate55B [13]
AU2017363246B2+Conjugate55+Payload
Undisclosed
AU2017363246B2+Conjugate55+Linker
 ADC Info 
AU2017363246B2 Conjugate55C [13]
AU2017363246B2+Conjugate55+Payload
Undisclosed
AU2017363246B2+Conjugate55+Linker
 ADC Info 
AU2017363246B2 Conjugate57 [13]
AU2017363246B2+Conjugate57+Payload
Undisclosed
AU2017363246B2+Conjugate57+Linker
 ADC Info 
AU2017363246B2 Conjugate59 [13]
AU2017363246B2+Conjugate59+Payload
Undisclosed
AU2017363246B2+Conjugate59+Linker
 ADC Info 
AU2017363246B2 Conjugate61 [13]
AU2017363246B2+Conjugate61+Payload
Undisclosed
AU2017363246B2+Conjugate61+Linker
 ADC Info 
AU2017363246B2 Conjugate66 [13]
AU2017363246B2+Conjugate66+Payload
Undisclosed
AU2017363246B2+Conjugate66+Linker
 ADC Info 
AU2017363246B2 Conjugate76 [13]
AU2017363246B2+Conjugate76+Payload
Undisclosed
AU2017363246B2+Conjugate76+Linker
 ADC Info 
AU2017363246B2 Conjugate78 [13]
AU2017363246B2+Conjugate78+Payload
Undisclosed
AU2017363246B2+Conjugate78+Linker
 ADC Info 
AU2017363246B2 Conjugate79A [13]
AU2017363246B2+Conjugate79+Payload
Undisclosed
AU2017363246B2+Conjugate79+Linker
 ADC Info 
AU2017363246B2 Conjugate79B [13]
AU2017363246B2+Conjugate79+Payload
Undisclosed
AU2017363246B2+Conjugate79+Linker
 ADC Info 
AU2017363246B2 Conjugate83 [13]
AU2017363246B2+Conjugate83+Payload
Undisclosed
AU2017363246B2+Conjugate83+Linker
 ADC Info 
AU2017363246B2 Conjugate85 [13]
AU2017363246B2+Conjugate85+Payload
Undisclosed
AU2017363246B2+Conjugate85+Linker
 ADC Info 
WO2019126691A1 Conjugate No.20A [14]
Conjugate No.10 Payload
Undisclosed
Conjugate No.5 Linker
 ADC Info 
WO2019126691A1 Conjugate No.73A [14]
Conjugate No.67 Payload
Undisclosed
Conjugate No.73 Linker
 ADC Info 
WO2019126691A1 Conjugate No.94A [14]
Conjugate No.94 Payload
Undisclosed
Conjugate No.94 Linker
 ADC Info 
WO2019126691A1 Conjugate No.135 [14]
Conjugate No.135 Payload
Undisclosed
Conjugate No.105 Linker
 ADC Info 
WO2019126691A1 Conjugate No.136 [14]
Conjugate No.136 Payload
Undisclosed
Conjugate No.105 Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BSI-715 [15]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-NaPi3b antibody-drug conjugate (Genentech/Roche) [16]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
NaPi2b-STINGa [17]
STINGa
Undisclosed
Undisclosed
 ADC Info 
ADRX-0134 [18]
AP052
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 NaPi2b targeting antibody-drug conjugates and methods of use thereof.
Ref 2 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 3 Quaternary ammonium compounds and their antibody-drug conjugates
Ref 4 Peptidomimetic compounds and antibody-drug conjugates thereof; 2015-09-03.
Ref 5 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 6 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 7 ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload. Cancer Res (2023) 83 (7_Supplement): 1533.
Ref 8 Anti-SLC34A2 antibodies, antibody-drug conjugates and methods of use
Ref 9 Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.
Ref 10 Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.
Ref 11 Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 12 Peptide-containing linkers for antibody-drug conjugates.
Ref 13 Peptide-containing linkers for antibody-drug conjugates
Ref 14 Pyrrolobenzodiazepine antibody conjugates
Ref 15 Introduction to basic information on ADC drug BSI-715.
Ref 16 Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. Ann Oncol. 2018 Apr 1;29(4):917-923.
Ref 17 Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses
Ref 18 ADRX-0134 as a novel auristatin-based NaPi2b antibody-drug conjugate with widened therapeutic window