Target Information

General Information of This Target
Target ID
PATR0EDEOA
Target Name
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Gene Name
MCL1
Gene ID
4170
Synonym
Bcl-2-like protein 3 (Bcl2-L-3); Bcl-2-related protein EAT/mcl1; mcl1/EAT; MCL1; BCL2L3
Sequence
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

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Family
Bcl-2 family
Function
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

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Uniprot Entry
MCL1_HUMAN
HGNC ID
HGNC:6943
KEGG ID
hsa:4170
Full List of The ADC Related to This Target
Phase 1/2
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
S-227928
Undisclosed
CD74
MIK665
valine-citrulline polyethylene glycol (PEG24)