Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0VNEYX
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| ADC Name |
t-ADC
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| Synonyms |
T-ADC
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| Organization |
CSPC MEGALITH BIOPHARMACEUTICAL CO.,LTD.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.5
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
(S)B19
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Payload Info | ||||
| Therapeutic Target |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
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Target Info | ||||
| Linker Name |
OXDc-VA-PAB (PEG)
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
LD38
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | 65% | Low HER2 expression (HER2+) | ||
| Method Description |
Investigated the antitumour effect of 3mg/kg T-ADC in a HER2low JIMT-1 xenograft NUNU mice tumour model, D26.
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| In Vivo Model | HER2-low JIMT-1 xenograft NUNU mice tumour model | ||||