Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0SUHDG
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| ADC Name |
wO2024169913A1 ADC04-01-8
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| Synonyms |
ADC04-01-8
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| Organization |
CSPC MEGALITH BIOPHARMACEUTICAL CO.,LTD.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
SYM004 (anti-DLL3)
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Antibody Info | ||||
| Antigen Name |
Delta-like protein 3 (DLL3)
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Antigen Info | ||||
| Payload Name |
B19
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Payload Info | ||||
| Therapeutic Target |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
LD01
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.06064 nM | High DLL3 expression (DLL3+++) | ||
| Method Description |
Cytotoxicity of ADC to NCI-H82 cells
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| In Vitro Model | Lung small cell carcinoma | NCI-H82 cells | CVCL_1591 | ||