Antibody Information

General Information of This Antibody

Antibody ID	ANI0UBOSC
Antibody Name	Anti-FGFR2 scFv ECD_FGFR2
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1 scFv
Antigen Name	Fibroblast growth factor receptor 2 (FGFR2)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

scFvF7-Fc-vcMMAE [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.89 nM	Positive FGFR2 expression (FGFR2+++/++)
Method Description	SNU-16, NCI-H716 and U2OS cells were seeded at a density of 5000 cells per well in a 96-well culture plate and treated with vcMMAE, scFvF7-Fc, or antibody-vcMMAE conjugate scFvF7-Fc-MMAE for 96 hours.
In Vitro Model	Gastric adenocarcinoma	SNU-16 cells		CVCL_0076
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	7.70 nM	Positive FGFR2 expression (FGFR2+++/++)
Method Description	SNU-16, NCI-H716 and U2OS cells were seeded at a density of 5000 cells per well in a 96-well culture plate and treated with vcMMAE, scFvF7-Fc, or antibody-vcMMAE conjugate scFvF7-Fc-MMAE for 96 hours.
In Vitro Model	Cecum adenocarcinoma	NCI-H716 cells		CVCL_1581

References

Ref 1	Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers. PLoS One. 2018 Feb 8;13(2):e0192194. doi: 10.1371/journal.pone.0192194. eCollection 2018.

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