Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0YRLWG
ADC Name
CN115429893A ADC7
Synonyms
CN115429893A ADC7
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Organization
Bio Thera Solutions Ltd
Drug Status
Investigative
Drug-to-Antibody Ratio
8.3
Structure
Antibody Name
Hrs9
  Antibody Info 
Antigen Name
Tumor-associated calcium signal transducer 2 (TACSTD2)
  Antigen Info 
Payload Name
CN115429893A ADC7 Payload
  Payload Info 
Linker Name
CN115429893A ADC7
  Linker Info 
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth lnhibition value (TGl) 
-20.85
%
Undisclosed Undisclosed
Tumor Growth lnhibition value (TGl) 
-20.85
%
Undisclosed Undisclosed
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl) -20.85% Positive Trop2 expression (Trop2+++/++)
Method Description
In the Capan-1 xenograft model, the ADCs were administered at 5 mg/kg (qwk × 3, IV).
In Vivo Model Capan-1 xenograft model
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl) -20.85% Positive Trop2 expression (Trop2+++/++)
Method Description
In the Capan-1 xenograft model, the ADCs were administered at 5 mg/kg (qwk × 3, IV).
In Vivo Model Capan-1 xenograft model
References
Ref 1 Drug conjugates and uses thereof