Payload Information
General Information of This Payload
| Payload ID | PAY0NXEST |
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|---|---|---|---|---|---|---|
| Name | CN115429893A ADC7 Payload |
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| Synonyms |
CN115429893A ADC7 Payload
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| Structure |
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| Formula | C22H20N2O5 |
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| Isosmiles | CC[C@@](C(C=C1C2=C(C(CC)=C3C(C=C(O)C=C3)=N2)CN1C4=O)=C4CO5)(O)C5=O |
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| InChI |
InChI=1S/C22H20N2O5/c1-3-12-13-6-5-11(25)7-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
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| InChIKey |
BHLPPDHMSXQHQJ-QFIPXVFZSA-N
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| Pharmaceutical Properties | Molecule Weight |
392.411 |
Polar area |
101.65 |
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Complexity |
1247.49406 |
xlogp Value |
2.3476 |
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Heavy Count |
29 |
Rot Bonds |
2 |
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Hbond acc |
7 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
CN115429893A ADC7 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
-20.85%
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Positive Trop2 expression (Trop2+++/++) | ||
| Method Description |
In the Capan-1 xenograft model, the ADCs were administered at 5 mg/kg (qwk × 3, IV).
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| In Vivo Model | Capan-1 xenograft model | ||||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
-20.85%
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Positive Trop2 expression (Trop2+++/++) | ||
| Method Description |
In the Capan-1 xenograft model, the ADCs were administered at 5 mg/kg (qwk × 3, IV).
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| In Vivo Model | Capan-1 xenograft model | ||||