Linker Information
General Information of This Linker
| Linker ID |
LIN0OCBVE
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| Linker Name |
CN115429893A ADC7
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C57H93N9O16
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| Isosmiles |
O=C(N1C[C@H]2CC[C@H](C(NCC(N=N3)=CN3CCOCCCOCCCOCCCOCCCOCCCOCCCOCCCOCCNC(COCC(N[C@@H](CCCCN)C(NC4=CC=C(C=C4)CO)=O)=O)=O)=O)CC2)C=CC1=O
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| InChI |
InChI=1S/C57H93N9O16/c58-21-2-1-10-51(57(73)61-49-17-13-47(43-67)14-18-49)62-53(69)45-82-44-52(68)59-22-38-80-36-8-34-78-32-6-30-76-28-4-26-74-24-3-25-75-27-5-29-77-31-7-33-79-35-9-37-81-39-23-65-42-50(63-64-65)40-60-56(72)48-15-11-46(12-16-48)41-66-54(70)19-20-55(66)71/h13-14,17-20,42,46,48,51,67H,1-12,15-16,21-41,43-45,58H2,(H,59,68)(H,60,72)(H,61,73)(H,62,69)/t46-,48-,51-/m0/s1
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| InChIKey |
VMGPCCOXHWFXHC-IFEXIISLSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1160.418
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Polar area
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313.81
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Complexity
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1978.629976
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xlogp Value
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2.3668
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Heavy Count
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82
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Rot Bonds
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51
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Hbond acc
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20
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN115429893A ADC7 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
-20.85%
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Positive Trop2 expression (Trop2+++/++) | ||
| Method Description |
In the Capan-1 xenograft model, the ADCs were administered at 5 mg/kg (qwk × 3, IV).
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| In Vivo Model | Capan-1 xenograft model | ||||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
-20.85%
|
Positive Trop2 expression (Trop2+++/++) | ||
| Method Description |
In the Capan-1 xenograft model, the ADCs were administered at 5 mg/kg (qwk × 3, IV).
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| In Vivo Model | Capan-1 xenograft model | ||||