Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0YOTWK
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| ADC Name |
cN113943310A ADC-15
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| Synonyms |
CN113943310A ADC-15
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| Organization |
SICHUAN BAILI PHARMACEUTICAL CO. LTD.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
7.5
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Compound 5
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase I (TOP1)
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Target Info | ||||
| Linker Name |
CN113943310A, ADC-12, Linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
L-H5
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | 95.96% | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
3x104 A431 cells were injected subcutaneously into the right shoulder of 4-6-week-old BALB/c nude mice, and when the average tumor size of the mice grew to 140 ~ 150mm3, they were randomly divided into 5 cells in each group. At day 0, day 7, day 14, day 21, intravenous injection of a blank control (blank buffer solution) and a dose of 10mg/kg antibody drug conjugate was administered. The tumor volume was measured at day 0, day 7, day 14, day 21, day 24, day 28, day 32, day 36 and the tumor growth inhibition rate on day 28 of d was calculated.
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| In Vivo Model | A431 tumor bearing nude mouse model | ||||