Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0YEVWK
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| ADC Name |
R&D (#893416)-MDpr-PEG (12)-gluc-MMAE
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| Synonyms |
R&D (#893416)-MDpr-PEG (12)-gluc-MMAE
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| Organization |
SEAGEN INC.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
R&D (#893416)
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Antibody Info | ||||
| Antigen Name |
Melanotransferrin (MELTF)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
MDpr-PEG (12)gluc
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
MDpr-PEG (12)gluc-MMAE
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
4 nM
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| Method Description |
Tumor cells (RPMI-7951+p97) were incubated with CD228 ADCs for 96-144 hours at 37°C. Cell viability was measured using Cell Titer Glo according to manufacturer'sinstructions.
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| In Vitro Model | Malignant melanoma | RPMI-7951 cells | CVCL_1666 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
6 nM
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| Method Description |
Tumor cells (SK-MEL-28) were incubated with CD228 ADCs for 96-144 hours at 37°C. Cell viability was measured using Cell Titer Glo according to manufacturer'sinstructions.
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| In Vitro Model | Cutaneous melanoma | SK-MEL-5 cells | CVCL_0527 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
55 nM
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| Method Description |
Tumor cells (SK-MEL-5) were incubated with CD228 ADCs for 96-144 hours at 37°C. Cell viability was measured using Cell Titer Glo according to manufacturer'sinstructions.
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| In Vitro Model | Cutaneous melanoma | SK-MEL-5 cells | CVCL_0527 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 444 nM | Moderate MELTF expression (MELTF++) | ||
| Method Description |
Tumor cells (A2058) were incubated with CD228 ADCs for 96-144 hours at 37°C. Cell viability was measured using Cell Titer Glo according to manufacturer'sinstructions.
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| In Vitro Model | Melanoma | A2058 cells | CVCL_1059 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 1000 nM | |||
| Method Description |
Tumor cells (RPMI-7951) were incubated with CD228 ADCs for 96-144 hours at 37°C. Cell viability was measured using Cell Titer Glo according to manufacturer'sinstructions.
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| In Vitro Model | Malignant melanoma | RPMI-7951 cells | CVCL_1666 | ||