Antigen Information

General Information of This Antigen
Antigen ID
TAR0IFMJZ
Antigen Name
Melanotransferrin (MELTF)
Gene Name
MELTF
Gene ID
4241
Synonym
MAP97; MFI2; Melanoma-associated antigen p97;CD_antigen=CD228
Sequence
MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA
DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT
IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS
YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT
LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ
RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN
RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL
SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF
GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ
GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE
LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKM
FDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAP
LLPLLLPALAARLLPPAL

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Family
Transferrin family
Function
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

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Uniprot Entry
TRFM_HUMAN
HGNC ID
HGNC:7037
KEGG ID
hsa:4241
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CD228 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BA1302
MMAE
Microtubule (MT)
MC-β-Ala-(glucuronide)-PABC
 ADC Info 
Biolegend (#363101)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Biolegend (#363101)-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
Chimeric L49
 Antibody Info 
ADC Name Payload Target Linker ADC Info
cL49-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
ADC Name Payload Target Linker ADC Info
SGN-CD228A
MMAE
Microtubule (MT)
Mal PEG12 based β-glucuronide linker
 ADC Info 
PF-08046031 [2]
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hL49-HALC
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49-HALC-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
hL49-HALC-AuristatinT [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-TubulysinM [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-LipophilicMMAF [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-PBD [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-MC-VC-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hL49-HALC-MDpr-gluc-MMAE [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49_27D_Ala
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_27D_Ala-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_27D_Gln
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_27D_Gln-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_27D_Tyr
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_27D_Tyr-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_34_Ala
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_34_Ala-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_34_Gln
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_34_Gln-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_34_Tyr
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_34_Tyr-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_3x_Ala
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_3x_Ala-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_3x_Gln
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_3x_Gln-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_3x_Tyr
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_3x_Tyr-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
hIgG-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
Humanized Anti-CD228 SGN-CD228A mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
mouse L235
 Antibody Info 
ADC Name Payload Target Linker ADC Info
mL235-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
mouse L49
 Antibody Info 
ADC Name Payload Target Linker ADC Info
mL49-MDpr-PEG (12)gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
R&D (#893416)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
R&D (#893416)-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
Santa Cruz (#271633)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Santa Cruz (#271633)-MDpr-PEG (12)gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
References
Ref 1 Anti-CD228 antibodies and antibody-drug conjugates
Ref 2 PF-08046031: A promising first-in-class antibody-drug conjugate for targeting novel tumor antigen in melanoma
Ref 3 Anti-cd228 antibodies and antibody-drug conjugates; 2022-02-10.