Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0XXGYA
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| ADC Name |
CN117337196A Compound88
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| Synonyms |
30kmPEG (SCAHer2 (1)xSCAHer2 (2))-3 (Val-Cit-PAB-DEA-SN38)
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| Organization |
Shenzhen Enduring Biotech Ltd.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
1
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| Structure |
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| Antibody Name |
SCAHer2 (1)xSCAHer (2)
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Active metabolite of irinotecan SN38
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
30kmPEG-Lys (PEG2 - Mal)-3 (Val-Cit-PAB-DEA)
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
30kmPEG-Lys (PEG2 - Mal)-3 (Val-Cit-PAB-DEA-SN38)
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Cell growth inhibition ratio | 10-40 % | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Her2-positive tumor cell line BXPC-3 cells were selected to be inoculated into 96-well plates with 3000 cells/well and treated with the compound 88 with a dose of 10 ug/mL. Cell viability was measured by Cell Counting Kit-8 (CCK-8), and cell proliferation inhibition rate was calculated
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||