Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0XSBGL
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| ADC Name |
PF-08046876
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| Synonyms |
PF-08046876
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| Organization |
Pfizer (Top20 MNC) (Originator)
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| Drug Status |
Phase 1
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
Sigvotatug
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Antibody Info | ||||
| Antigen Name |
Integrin beta-6 (ITGB6)
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Antigen Info | ||||
| Payload Name |
AMDCPT
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
Mal based β-glucuronide linker
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Linker Info | ||||
| Conjugate Type |
Random Cysteines
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Head and neck cancer |
1 Trials
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| Lung cancer |
1 Trials
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| Oesophageal cancer |
1 Trials
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| Pancreatic cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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| Urothelial cancer |
1 Trials
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