Antigen Information

General Information of This Antigen
Antigen ID
TAR0AIVIM
Antigen Name
Integrin beta-6 (ITGB6)
Gene Name
ITGB6
Sequence
MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCD
TPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQT
LQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEK
PVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPE
GGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNE
YSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNI
LQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVT
VNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCA
CHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCD
NFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCG
KCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEE
DFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAIL
LIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQ
KVDLSTDC

    Click to Show/Hide
Family
Integrin alpha chain family
Function
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G- D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.

    Click to Show/Hide
Uniprot Entry
ITB6_HUMAN
HGNC ID
HGNC:6161
KEGG ID
hsa:3694
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-ITGB6 full human IgG1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
sKB105
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Kthiol (pyrimidine-thiol) oligopeptide linker
Anti-ITGB6 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
pF-08052667
MMAE
Microtubule (MT)
Mal PEG12 based β-glucuronide linker
Sigvotatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Sigvotatug vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
Sigvotatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PF-08046876
AMDCPT
DNA topoisomerase 1 (TOP1)
Mal based β-glucuronide linker
 [1]
References
Ref 1 PF-08046876: A new camptothecin antibody-drug conjugate directed to integrin beta-6 with potent antitumor activity in multiple preclinical solid tumor models