Antigen Information

General Information of This Antigen
Antigen ID
TAR0UKZBL
Antigen Name
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Gene Name
IL13RA2
Gene ID
3598
Synonym
IL13R; Interleukin-13-binding protein;CD_antigen=CD213a2
Sequence
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD
HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ
SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH
ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP
PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE
TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG
LLLRKPNTYPKMIPEFFCDT

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Family
Cytokine receptor type I family
Function
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

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Uniprot Entry
I13R2_HUMAN
HGNC ID
HGNC:5975
KEGG ID
hsa:3598
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2025019776A2ADC 22-2
Monomethyl auristatin E
Microtubule (MT)
WO2025019776A2, ADC 22-2, Linker
 [1]
 ADC Info 
WO2025019776A2ADC 22-8
Belotecan
DNA topoisomerase 1 (TOP1)
WO2025019776A2, ADC 22-8, Linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2025019776A2ADC 33-2
Monomethyl auristatin E
Microtubule (MT)
WO2025019776A2, ADC 22-2, Linker
 [1]
 ADC Info 
WO2025019776A2ADC 33-8
Belotecan
DNA topoisomerase 1 (TOP1)
WO2025019776A2, ADC 22-8, Linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2025019776A2ADC 52-2
Monomethyl auristatin E
Microtubule (MT)
WO2025019776A2, ADC 22-2, Linker
 [1]
 ADC Info 
WO2025019776A2ADC 52-8
Belotecan
DNA topoisomerase 1 (TOP1)
WO2025019776A2, ADC 22-8, Linker
 [1]
Anti-IL13RA2 mAb 2E10
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-IL13RA2 PBD ADC
SGD-1882
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 [2]
Anti-IL13RA2 mAb huCl47
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ADCT-211
SG2000
Human Deoxyribonucleic acid (hDNA)
Vali-Ala cleavable linker
 [3]
Anti-IL13RA2 PF-06473811 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-IL13RA2-ADC
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuCL47-B1
B4 Payload
Deoxyribonucleic acid (DNA)
US20230285580A1 B12-B2 linker
 [5]
 ADC Info 
HuCL47-B2
US20230285580A1 B12-B3 payload
Undisclosed
US20230285580A1 B12-B2 linker
 [5]
 ADC Info 
HuCL47-B3
US20230285580A1 B12-B3 payload
Undisclosed
US20230285580A1 B12-B6 linker
 [5]
 ADC Info 
HuCL47-B4
US20230285580A1 B12-B4 payload
Undisclosed
US20230285580A1 B12-B6 linker
 [5]
 ADC Info 
HuCL47-B6
B4 Payload
Deoxyribonucleic acid (DNA)
US20230285580A1 B12-B6 linker
 [5]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
LM-306
Undisclosed
Undisclosed
Undisclosed
 [6]
References
Ref 1 Interleukin-13 receptor subunit alpha-2 antibody-drug conjugates and uses thereof
Ref 2 Design considerations of an IL13R2 antibody-drug conjugate for diffuse intrinsic pontine glioma. Acta Neuropathol Commun. 2021 May 17;9(1):88. doi: 10.1186/s40478-021-01184-9.
Ref 3 Preclinical development of ADCT-211, a novel pyrrolobenzodiazepine dimer-based antibody-drug conjugate targeting solid tumors expressing IL13RA2. Cancer Res (2023) 83 (7_Supplement): 1604.
Ref 4 Targeting and pharmacology of an anti-IL13R2 antibody and antibody-drug conjugate in a melanoma xenograft model. MAbs. 2021 Jan-Dec;13(1):1958662.
Ref 5 Anti-IL-13Rα2 conjugates
Ref 6 Pre-clinical evaluation of a novel antibody drug conjugate (ADC) LM-306 targeting IL-13R2 in immuno-oncology. Cancer Res (2023) 83 (7_Supplement): 1881.