Antigen Information

General Information of This Antigen (ID: TAR0UKZBL)
Antigen Name
Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Gene Name
IL13RA2
Gene ID
3598
Synonym
IL13R; Interleukin-13-binding protein;CD213a2
Sequence
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD
HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ
SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH
ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP
PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE
TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG
LLLRKPNTYPKMIPEFFCDT

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Family
Cytokine receptor type I family
Function
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

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Uniprot Entry
I13R2_HUMAN
HGNC ID
HGNC:5975
KEGG ID
hsa:3598
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
WO2025019776A2ADC 22-2 [1]
Monomethyl auristatin E
Microtubule (MT)
WO2025019776A2, ADC 22-2, Linker
 ADC Info 
WO2025019776A2ADC 22-8 [1]
Belotecan
DNA topoisomerase 1 (TOP1)
WO2025019776A2, ADC 22-8, Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2025019776A2ADC 33-2 [1]
Monomethyl auristatin E
Microtubule (MT)
WO2025019776A2, ADC 22-2, Linker
 ADC Info 
WO2025019776A2ADC 33-8 [1]
Belotecan
DNA topoisomerase 1 (TOP1)
WO2025019776A2, ADC 22-8, Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2025019776A2ADC 52-2 [1]
Monomethyl auristatin E
Microtubule (MT)
WO2025019776A2, ADC 22-2, Linker
 ADC Info 
WO2025019776A2ADC 52-8 [1]
Belotecan
DNA topoisomerase 1 (TOP1)
WO2025019776A2, ADC 22-8, Linker
 ADC Info 
Anti-IL13RA2 mAb 2E10
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-IL13RA2 PBD ADC [2]
SGD-1882
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
Anti-IL13RA2 mAb huCl47
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ADCT-211 [3]
SG2000
Human Deoxyribonucleic acid (hDNA)
Vali-Ala cleavable linker
 ADC Info 
Anti-IL13RA2 PF-06473811 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-IL13RA2-ADC [4]
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
HuCL47-B1 [5]
B4 Payload
Deoxyribonucleic acid (DNA)
US20230285580A1 B12-B2 linker
 ADC Info 
HuCL47-B2 [5]
US20230285580A1 B12-B3 payload
Undisclosed
US20230285580A1 B12-B2 linker
 ADC Info 
HuCL47-B3 [5]
US20230285580A1 B12-B3 payload
Undisclosed
US20230285580A1 B12-B6 linker
 ADC Info 
HuCL47-B4 [5]
US20230285580A1 B12-B4 payload
Undisclosed
US20230285580A1 B12-B6 linker
 ADC Info 
HuCL47-B6 [5]
B4 Payload
Deoxyribonucleic acid (DNA)
US20230285580A1 B12-B6 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
LM-306 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Interleukin-13 receptor subunit alpha-2 antibody-drug conjugates and uses thereof
Ref 2 Design considerations of an IL13R2 antibody-drug conjugate for diffuse intrinsic pontine glioma. Acta Neuropathol Commun. 2021 May 17;9(1):88. doi: 10.1186/s40478-021-01184-9.
Ref 3 Preclinical development of ADCT-211, a novel pyrrolobenzodiazepine dimer-based antibody-drug conjugate targeting solid tumors expressing IL13RA2. Cancer Res (2023) 83 (7_Supplement): 1604.
Ref 4 Targeting and pharmacology of an anti-IL13R2 antibody and antibody-drug conjugate in a melanoma xenograft model. MAbs. 2021 Jan-Dec;13(1):1958662.
Ref 5 Anti-IL-13Rα2 conjugates
Ref 6 Pre-clinical evaluation of a novel antibody drug conjugate (ADC) LM-306 targeting IL-13R2 in immuno-oncology. Cancer Res (2023) 83 (7_Supplement): 1881.