Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0UJMPA
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| ADC Name |
BA1302
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| Synonyms |
BA1302
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| Organization |
BioRay Biopharmaceutical (Boan Biotech) (Originator)
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| Drug Status |
Phase 1
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
Anti-CD228 antibody
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Antibody Info | ||||
| Antigen Name |
Melanotransferrin (MELTF)
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Antigen Info | ||||
| Payload Name |
MMAE
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
MC-β-Ala-(glucuronide)-PABC
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Linker Info | ||||
| Conjugate Type |
Random Cysteines
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| Combination Type |
BNLD11
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Pancreatic cancer |
1 Trials
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| Lung cancer |
1 Trials
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| Melanoma |
1 Trials
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| Breast cancer |
1 Trials
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Inclusion criteria require histologically confirmed metastatic/unresectable solid tumors (Part A: any advanced solid tumors; Part B: specific cancers including melanoma, breast cancer, NSCLC, or pancreatic adenocarcinoma) with progression after standard therapy, ECOG ≤1, measurable disease by RECIST v1.1, and available tumor tissue for biomarker analysis. Exclusions comprise other active malignancies within 5 years (except certain cured cancers), recent anticancer treatments (≤28 days), severe drug hypersensitivity, pregnancy/lactation, or conditions compromising safety/study compliance.
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| Administration Dosage |
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| Related Clinical Trial | |||||
| NCT Number | NCT06596915 | Clinical Status | PHASE1 | ||
| Clinical Description | A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Preliminary Efficacy of BA1302 in Patients With Advanced Solid Malignancies | ||||
| Primary Endpoint |
The primary safety endpoints include the number of participants experiencing dose-limiting toxicities (DLTs) within the first 21 days and adverse events (AEs) recorded through 28 days after the last treatment.
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| Other Endpoint |
Key secondary endpoints focus on pharmacokinetics (AUC0-t, AUC0-inf, Cmax, t1/2, and AUC at steady state) and immunogenicity (ADA incidence), all evaluated over approximately one year. Efficacy measures comprise objective response rate (ORR) and duration of response (DOR) per RECIST v1.1.
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