Antigen Information

General Information of This Antigen
Antigen ID
TAR0KILQS
Antigen Name
Tomoregulin-2 (TMEFF2)
Gene Name
TMEFF2
Gene ID
23671
Synonym
HPP1; TENB2; TPEF; UNQ178; PRO204; Hyperplastic polyposis protein 1;Transmembrane protein with EGF-like and two follistatin-like domains
Sequence
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYD
DRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAA
CKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWC
VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG
HYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHC
EKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGH
YSSDNTTRASTRLI

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Family
TNFR8 family
Function
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

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Uniprot Entry
TEFF2_HUMAN
HGNC ID
HGNC:11867
KEGG ID
hsa:23671
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-TENB2 monoclonal Anti-ody (mAb)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-TenB2 antibody drug conjugate
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
Anti-TMEFF2 mAb huPr1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huPr1-vcMMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
References
Ref 1 Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer. Oncotarget. 2019 Oct 22;10(58):6234-6244. doi: 10.18632/oncotarget.27263. eCollection 2019 Oct 22.
Ref 2 An overview of huPr1-vcMMAE.

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