Antigen Information

General Information of This Antigen (ID: TAR0KILQS)
Antigen Name
Tomoregulin-2 (TMEFF2)
Gene Name
TMEFF2
Gene ID
23671
Synonym
HPP1; TENB2; TPEF; UNQ178; PRO204; Hyperplastic polyposis protein 1;Transmembrane protein with EGF-like and two follistatin-like domains
Sequence
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYD
DRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAA
CKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWC
VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG
HYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHC
EKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGH
YSSDNTTRASTRLI

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Family
TNFR8 family
Function
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

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Uniprot Entry
TEFF2_HUMAN
HGNC ID
HGNC:11867
KEGG ID
hsa:23671
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-TENB2 monoclonal Anti-ody (mAb)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-TenB2 antibody drug conjugate [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-TMEFF2 mAb huPr1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
huPr1-vcMMAE [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
References
Ref 1 Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer. Oncotarget. 2019 Oct 22;10(58):6234-6244. doi: 10.18632/oncotarget.27263. eCollection 2019 Oct 22.
Ref 2 An overview of huPr1-vcMMAE.