Linker Information
General Information of This Linker
| Linker ID |
LIN0JTHRT
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| Linker Name |
CN118001423A+ADC3+Linker
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Unclear
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| Structure |
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| Formula |
C43H75BrN6O16
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| Isosmiles |
COCCOCCOCCOCCN(CCOCCOCCOCCOC)C(C1=C(CO)C=CC(NC([C@@H](NC(CNC(CCOCCOCCNC(CBr)=O)=O)=O)CCCCN)=O)=C1)=O
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| InChI |
InChI=1S/C43H75BrN6O16/c1-57-17-19-63-27-29-65-25-23-61-15-11-50(12-16-62-24-26-66-30-28-64-20-18-58-2)43(56)37-31-36(7-6-35(37)34-51)48-42(55)38(5-3-4-9-45)49-41(54)33-47-39(52)8-13-59-21-22-60-14-10-46-40(53)32-44/h6-7,31,38,51H,3-5,8-30,32-34,45H2,1-2H3,(H,46,53)(H,47,52)(H,48,55)(H,49,54)/t38-/m0/s1
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| InChIKey |
CAGOMVDNYVTKDN-LHEWISCISA-N
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| Pharmaceutical Properties |
Molecule Weight
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1012.003
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Polar area
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275.26
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Complexity
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1325.745946
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xlogp Value
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-0.3836
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Heavy Count
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66
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Rot Bonds
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45
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Hbond acc
|
17
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN118001423A ADC3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
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| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
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| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
CN118001423A ADC4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
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| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
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| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 200≈1000 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
References