Payload Information
General Information of This Payload
| Payload ID | PAY0XMTUJ |
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| Name | CN118001423A+ADC4+payload |
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| Synonyms |
CN118001423A+ADC4+payload
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| Structure |
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| Formula | C28H31N3O7 |
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| Isosmiles | CC[C@@](C(C=C1C2C(CN31)=C(C4=CC(OCO5)=C5C=C4N2)CCNC6CCOCC6)=C(C3=O)CO7)(O)C7=O |
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| InChI |
InChI=1S/C28H31N3O7/c1-2-28(34)20-10-22-25-18(12-31(22)26(32)19(20)13-36-27(28)33)16(3-6-29-15-4-7-35-8-5-15)17-9-23-24(38-14-37-23)11-21(17)30-25/h9-11,15,25,29-30,34H,2-8,12-14H2,1H3/t25?,28-/m0/s1
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| InChIKey |
UJBMBDJTZBOUSP-NMXAJACMSA-N
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| Pharmaceutical Properties | Molecule Weight |
521.57 |
Polar area |
120.28 |
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Complexity |
1384.092281 |
xlogp Value |
2.3241 |
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Heavy Count |
38 |
Rot Bonds |
5 |
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Hbond acc |
10 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
CN118001423A ADC4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
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| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
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| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 200≈1000 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
References