Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0TOZVI
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
WO2024193682A1 8H10-ADC
|
|||||
| Synonyms |
8H10-ADC
Click to Show/Hide
|
|||||
| Organization |
XADCERA BIOPHARMACEUTICAL (SUZHOU) CO., LTD.
|
|||||
| Drug Status |
Investigative
|
|||||
| Antibody Name |
8H10
|
Antibody Info | ||||
| Antigen Name |
Trophoblast glycoprotein (TPBG)
|
Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
|
Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
|
Target Info | ||||
| Linker Name |
Undisclosed
|
|||||
General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
1.138 ug/ml
|
|||
| Method Description |
Series diluted ADCs (maximum concentration: 20 ug/mL, 3-fold dilutions, 10 gradients)were used to treat human lung squamous carcinoma NCI-H226 5000cells cultured in a cellculture plate, and the killing activity was detected after 72 hours of incubation in IncuCyte (Sartorius AG, IncuCytee S3).
|
||||
| In Vitro Model | Pleural epithelioid mesothelioma | NCI-H226 cells | CVCL_1544 | ||