Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0SWSSG
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| ADC Name |
AU2023308528A1 ADC7
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| Synonyms |
AU2023308528A1 ADC7
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| Organization |
PHEON THERAPEUTICS LTD
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2.1
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
N- (4- ((S)-2- ((S)-2-amino-3- methylbutanamido)propanamido)phenyl)-4- (4- (4- (4- (( (S)-2-methoxy-12-oxo-6a,7,8,9,10,12-hexahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-3-yl)oxy)butanamido)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamide
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase I (TOP1)
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Target Info | ||||
| Linker Name |
(S)-75-oxo-76- (4- (3-tosyl-2- (tosylmethyl)propanoyl)benzamido) 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71-tetracosaoxa-74 azanonaheptacontan-79-oic acid
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
(S)-N5- ((S)-1- (( (S)-1- ((4- (4- (4- (4- (4- (( (S)-2-Methoxy-12-oxo-6a,7,8,9,10,12 hexahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-3-yl)oxy)butanamido)-1-methyl-1H pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)amino)-1 oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-2- (4- (3-tosyl-2 (tosylmethyl)propanoyl)benzamido)-N1- (2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71 tetracosaoxatriheptacontan-73-yl)pentanediamide
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