Linker Information

General Information of This Linker
Linker ID
LIN0TTWZX
Linker Name
AcLys-Val-Cit-PABC-DMAE
Linker Type
Cathepsin-cleavable linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C31H53N9O7
Isosmiles
CNCCN(C)C(=O)OCc1ccc(NC(=O)C(CCCNC(N)=O)NC(=O)C(NC(=O)C(CCCCN)NC(C)=O)C(C)C)cc1
InChI
InChI=1S/C31H53N9O7/c1-20(2)26(39-28(43)24(36-21(3)41)9-6-7-15-32)29(44)38-25(10-8-16-35-30(33)45)27(42)37-23-13-11-22(12-14-23)19-47-31(46)40(5)18-17-34-4/h11-14,20,24-26,34H,6-10,15-19,32H2,1-5H3,(H,36,41)(H,37,42)(H,38,44)(H,39,43)(H3,33,35,45)
InChIKey
HPLLJPILYHTYNS-UHFFFAOYSA-N
Pharmaceutical Properties
Molecule Weight
663.821
Polar area
239.11
Complexity
47
xlogp Value
0.1207
Heavy Count
47
Rot Bonds
21
Hbond acc
9
Hbond Donor
8
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
PF-06888667 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 100.00% (Day 35) High HER2 expression (HER2+++)
Method Description
Athymic mice were inoculated with HER2-positive N87 tumor cells. When tumors reached approximately 300 mm3, mice were administered PBS vehicle or the indicated ADCs at 1 mg/kg every 4 days (days 1, 5, 9, 13).
In Vivo Model NCI-N87 CDX model
In Vitro Model Gastric tubular adenocarcinoma NCI-N87 cells CVCL_1603
References
Ref 1 Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjug Chem. 2019 Jan 16;30(1):200-209. doi: 10.1021/acs.bioconjchem.8b00843. Epub 2018 Dec 13.

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