Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0NAZIB)
| ADC Name |
AZD0516
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| Synonyms |
AZD0516
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| Organization |
AstraZeneca (Top20 MNC) (Originator)
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| Drug Status |
Phase 1/2
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| Antibody Name |
Anti-STEAP2 mAb
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Antibody Info | ||||
| Antigen Name |
Metalloreductase STEAP2 (STEAP2)
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Antigen Info | ||||
| Payload Name |
Exatecan
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Payload Info | ||||
| Payload Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
A cleavable linker
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Linker Info | ||||
| Conjugate Type |
Random Cysteines
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2027 Update
The disease landscape of This ADC
2027 Update
The clinical trial pipelines of This ADC
| Indication | Phase 1 | Phase 2 | Phase 3 | Approved | ||
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| Prostate cancer |
1 Trials
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2027 Update
ADC-specific functional property
Bystander Killing Effect
| Bystander Killing Effect | Description | Reference |
|---|---|---|
| yes |
Exatecan-driven bystander cell killing from intracellular release of payload was demonstrated in co-culture systems involving STEAP2-positive and negative cell lines.
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[1]
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References