Antigen Information
General Information of This Antigen (ID: TAR0PHQVA)
| Antigen Name | Metalloreductase STEAP2 (STEAP2) |
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|---|---|---|---|---|---|---|
| Gene Name | STEAP2 |
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| Gene ID | ||||||
| Synonym | PCANAP1; STAMP1; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1 |
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| Sequence |
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGS
RNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNM RINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIE LARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYA RNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQ CRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMY ISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFE EEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIP HVSPERVTVM Click to Show/Hide
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| Family | STEAP family |
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| Function |
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
| KEGG ID | ||||||
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Anti-STEAP2 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN110088138A ADC-1
[1]
|
CN110088138A ADC-1 payload |
Undisclosed |
CN110088138A ADC-1 linker |
|
|
AZD0516
[2]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
A cleavable linker |
|
|
TRSQ-ZP3A-LP4
[3]
|
CL202203715A1 P34 |
Undisclosed |
BCN-PEG4-EvcPAB linker |
|
|
TRSQ-ZP3A-LP5
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-GGG linker |
|
|
TRSQ-ZP3A-LP6
[3]
|
CL202203715A1 P34 |
Undisclosed |
BCN-GGGG linker |
|
|
TRSQ-ZP3A-LP7
[3]
|
CL202203715A1 P34 |
Undisclosed |
DIBAC-PEG4-GGFG linker |
|
|
TRSQ-ZP3A-LP8
[3]
|
CL202203715A1 P34 |
Undisclosed |
BCN-PEG4-GGFG linker |
|
|
TRSQ-ZP3A-LP9
[3]
|
CL202203715A1 P51 |
Undisclosed |
COT-PEG3-HOPAS linker |
|
|
TRSQ-ZP3A-LP11
[3]
|
CL202203715A1 P1 |
Undisclosed |
BCN-PEG4-GGFG linker |
|
|
TRSQ-ZP3A-LP10
[3]
|
CL202203715A1 P1 |
Undisclosed |
BCN-GGFG linker |
|
|
TRSQ-ZP3A-LP12
[3]
|
CL202203715A1 P7 |
Undisclosed |
DIBAC-PEG4-vcPAB-Gly linker |
|
|
TRSQ-ZP3A-LP13
[3]
|
CL202203715A1 P7 |
Undisclosed |
DIBAC-PEG4-vcPAB |
|
|
TRSQ-ZP3A-LP26
[3]
|
CL202203715A1 P7 |
Undisclosed |
DIBAC-PEG4-EvcPAB-Gly linker |
|
|
CTRL-ZP3A-LP26
[3]
|
CL202203715A1 P7 |
Undisclosed |
DIBAC-PEG4-EvcPAB-Gly linker |
|
|
TRSQ-ZP3A-LP16
[3]
|
CL202203715A1 P5 |
Undisclosed |
DIBAC-PEG4-EvcPAB linker |
|
|
TRSQ-ZP3A-LP18
[3]
|
CL202203715A1 P5 |
Undisclosed |
DIBAC-PEG4-GGG linker |
|
|
TRSQ-ZP3A-LP19
[3]
|
CL202203715A1 P5 |
Undisclosed |
BCN-PEG4-GGFG linker |
|
|
TRSQ-ZP3A-LP20
[3]
|
CL202203715A1 P11 |
Undisclosed |
DIBAC-PEG4-vcPAB |
|
|
TRSQ-ZP3A-LP21
[3]
|
CL202203715A1 P11 |
Undisclosed |
DBCO-PEG3-amine |
|
|
TRSQ-ZP3A-LP22
[3]
|
CL202203715A1 P43 |
Undisclosed |
DIBAC-PEG4 linker |
|
|
CTRL-ZP3A-LP22
[3]
|
CL202203715A1 P43 |
Undisclosed |
DIBAC-PEG4 linker |
|
|
TRSQ-ZP3A-LP25
[3]
|
CL202203715A1 P46 |
Undisclosed |
DIBAC-PEG4-vcPAB |
|
|
TRSQ-ZP3A-LP24
[3]
|
CL202203715A1 P47 |
Undisclosed |
DIBAC-PEG4 linker |
|
|
CTRL-ZP3A-LP24
[3]
|
CL202203715A1 P47 |
Undisclosed |
DIBAC-PEG4 linker |
|
|
TRSQ-ZP3A- LP4-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
DIBAC-PEG4-vcPAB |
|
|
CTRL-ZP3A-LP4-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
DIBAC-PEG4-vcPAB |
|
|
TRSQ-ZP3A- LP25-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-EDA- (GLCA)PAB linker |
|
|
CTRL-ZP3A- LP25-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-EDA- (GLCA)PAB linker |
|
|
TRSQ-ZP3A- LP26-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-EDA- (GLC)PAB linker |
|
|
CTRL-ZP3A- LP26-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-EDA- (GLC)PAB linker |
|
|
TRSQ-ZP3A-LP17-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-GG linker |
|
|
TRSQ-ZP3A-LP13-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
DIBAC-GGG- linker |
|
|
TRSQ-ZP3A- LP19-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-GGGG linker |
|
|
TRSQ-ZP3A- LP20-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
DIBAC-GGFG linker |
|
|
TRSQ-ZP3A- LP21-Ve
[3]
|
CL202203715A1 P34 |
Undisclosed |
COT-GGG-E linker |
|
|
TRSQ-ZP3A- LP6-Vb
[3]
|
CL202203715A1 Vb |
Undisclosed |
DIBAC-PEG4 linker |
|
|
TRSQ-ZP3A- LP24-Vb
[3]
|
CL202203715A1 Vb |
Undisclosed |
DIBAC-GGFG linker |
|
|
TRSQ-ZP3A- LP23-Vb
[3]
|
CL202203715A1 Vb |
Undisclosed |
COT-GGGG linker |
|
|
TRSQ-ZP3A- LP15-Vlh
[3]
|
CL202203715A1 Vlh |
Undisclosed |
DIBAC-PEG4-vcPAB |
H1H7841N
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
H1H7841N-7
[4]
|
undisclosed |
Undisclosed |
Undisclosed |
References