Antigen Information

General Information of This Antigen
Antigen ID
TAR0PHQVA
Antigen Name
Metalloreductase STEAP2 (STEAP2)
Gene Name
STEAP2
Synonym
PCANAP1; STAMP1; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
Sequence
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGS
RNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNM
RINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIE
LARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYA
RNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQ
CRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMY
ISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFE
EEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIP
HVSPERVTVM

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Family
STEAP family
Function
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.

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Uniprot Entry
STEA2_HUMAN
HGNC ID
HGNC:17885
KEGG ID
hsa:261729
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-STEAP2 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN110088138A ADC-1
CN110088138A ADC-1 payload
Undisclosed
CN110088138A ADC-1 linker
 [1]
 ADC Info 
AZD0516
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [2]
 ADC Info 
TRSQ-ZP3A-LP4
CL202203715A1 P34
Undisclosed
BCN-PEG4-EvcPAB linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP5
CL202203715A1 P34
Undisclosed
COT-GGG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP6
CL202203715A1 P34
Undisclosed
BCN-GGGG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP7
CL202203715A1 P34
Undisclosed
DIBAC-PEG4-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP8
CL202203715A1 P34
Undisclosed
BCN-PEG4-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP9
CL202203715A1 P51
Undisclosed
COT-PEG3-HOPAS linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP11
CL202203715A1 P1
Undisclosed
BCN-PEG4-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP10
CL202203715A1 P1
Undisclosed
BCN-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP12
CL202203715A1 P7
Undisclosed
DIBAC-PEG4-vcPAB-Gly linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP13
CL202203715A1 P7
Undisclosed
DIBAC-PEG4-vcPAB
 [3]
 ADC Info 
TRSQ-ZP3A-LP26
CL202203715A1 P7
Undisclosed
DIBAC-PEG4-EvcPAB-Gly linker
 [3]
 ADC Info 
CTRL-ZP3A-LP26
CL202203715A1 P7
Undisclosed
DIBAC-PEG4-EvcPAB-Gly linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP16
CL202203715A1 P5
Undisclosed
DIBAC-PEG4-EvcPAB linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP18
CL202203715A1 P5
Undisclosed
DIBAC-PEG4-GGG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP19
CL202203715A1 P5
Undisclosed
BCN-PEG4-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP20
CL202203715A1 P11
Undisclosed
DIBAC-PEG4-vcPAB
 [3]
 ADC Info 
TRSQ-ZP3A-LP21
CL202203715A1 P11
Undisclosed
DBCO-PEG3-amine
 [3]
 ADC Info 
TRSQ-ZP3A-LP22
CL202203715A1 P43
Undisclosed
DIBAC-PEG4 linker
 [3]
 ADC Info 
CTRL-ZP3A-LP22
CL202203715A1 P43
Undisclosed
DIBAC-PEG4 linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP25
CL202203715A1 P46
Undisclosed
DIBAC-PEG4-vcPAB
 [3]
 ADC Info 
TRSQ-ZP3A-LP24
CL202203715A1 P47
Undisclosed
DIBAC-PEG4 linker
 [3]
 ADC Info 
CTRL-ZP3A-LP24
CL202203715A1 P47
Undisclosed
DIBAC-PEG4 linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP4-Ve
CL202203715A1 P34
Undisclosed
DIBAC-PEG4-vcPAB
 [3]
 ADC Info 
CTRL-ZP3A-LP4-Ve
CL202203715A1 P34
Undisclosed
DIBAC-PEG4-vcPAB
 [3]
 ADC Info 
TRSQ-ZP3A- LP25-Ve
CL202203715A1 P34
Undisclosed
COT-EDA- (GLCA)PAB linker
 [3]
 ADC Info 
CTRL-ZP3A- LP25-Ve
CL202203715A1 P34
Undisclosed
COT-EDA- (GLCA)PAB linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP26-Ve
CL202203715A1 P34
Undisclosed
COT-EDA- (GLC)PAB linker
 [3]
 ADC Info 
CTRL-ZP3A- LP26-Ve
CL202203715A1 P34
Undisclosed
COT-EDA- (GLC)PAB linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP17-Ve
CL202203715A1 P34
Undisclosed
COT-GG linker
 [3]
 ADC Info 
TRSQ-ZP3A-LP13-Ve
CL202203715A1 P34
Undisclosed
DIBAC-GGG- linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP19-Ve
CL202203715A1 P34
Undisclosed
COT-GGGG linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP20-Ve
CL202203715A1 P34
Undisclosed
DIBAC-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP21-Ve
CL202203715A1 P34
Undisclosed
COT-GGG-E linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP6-Vb
CL202203715A1 Vb
Undisclosed
DIBAC-PEG4 linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP24-Vb
CL202203715A1 Vb
Undisclosed
DIBAC-GGFG linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP23-Vb
CL202203715A1 Vb
Undisclosed
COT-GGGG linker
 [3]
 ADC Info 
TRSQ-ZP3A- LP15-Vlh
CL202203715A1 Vlh
Undisclosed
DIBAC-PEG4-vcPAB
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H1H7841N-7
undisclosed
Undisclosed
Undisclosed
 [4]
References
Ref 1 Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof.
Ref 2 Preclinical characterization of AZD0516, a novel STEAP2 antibody-drug conjugate (ADC) for the treatment of prostate cancer
Ref 3 Tubulysins and protein-tubulysin conjugates
Ref 4 Anti-STEAP2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind STEAP2 and CD3, and uses thereof