Payload Information
General Information of This Payload
| Payload ID | PAY0QUEHW |
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|---|---|---|---|---|---|---|
| Name | Tubulysin analogue 3 |
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| Synonyms |
Tubulysin analogue 3
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| Target(s) | Microtubule (MT) | |||||
| Structure |
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| Formula | C38H57N5O7S |
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| Isosmiles | CCC(C)C(NC(=O)C1CCCCN1C)C(=O)N(C)C(CC(OC(C)=O)c1nc(C(=O)NC(Cc2ccccc2)CC(C)C(=O)O)cs1)C(C)C |
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| InChI |
InChI=1S/C38H57N5O7S/c1-9-24(4)33(41-35(46)30-17-13-14-18-42(30)7)37(47)43(8)31(23(2)3)21-32(50-26(6)44)36-40-29(22-51-36)34(45)39-28(19-25(5)38(48)49)20-27-15-11-10-12-16-27/h10-12,15-16,22-25,28,30-33H,9,13-14,17-21H2,1-8H3,(H,39,45)(H,41,46)(H,48,49)
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| InChIKey |
POBZYODNVHQLFG-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
727.969 |
Polar area |
158.24 |
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Complexity |
51 |
xlogp Value |
5.0875 |
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Heavy Count |
51 |
Rot Bonds |
18 |
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Hbond acc |
9 |
Hbond Donor |
3 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half-maximal effective concentration (EC50) | 0.72 | nmol/L |
L-540 cells
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Hodgkin lymphoma
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[1] | |
| Half-maximal effective concentration (EC50) | 0.9 | nmol/L |
L-428 cells
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Hodgkin lymphoma
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[1] | |
| Half-maximal effective concentration (EC50) | 4 | nmol/L |
786-O cells
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Renal cell carcinoma
|
[1] |
Each Antibody-drug Conjugate Related to This Payload
References
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