B-NDG mice were engrafted in the right flank with gastric cancer patient-derived tumortissue fragments (2 mm x 2 mm x 2 mm). The immunofluorescence staining results showed that TPBG-positive cells and MET-positive cells in the gastric tumor fragments were 10.1 1% and 1.19%, respectively, When the tumors in the mice reached a volume of about 200-300 mm³, the mice were randomly placed into different groups based on the tumor volume. The mice werethen injected with 6mg/kg ADC's by i.v, QW, administration. Determined tumor volume after the experiment, measured at day 35.

B-NDG mice were engrafted in the right flank with pancreatic cancer patient-derivedtumor tissue fragments (2 mm x 2 mm x 2 mm). The immunofluorescence staining results showed that TPGB-positive cells and MET-positive cells in the pancreatic tumor fragments were 19.54% and 8.31%, respectively. When the tumors in the mice reached a volume of about 200-300 mm³, the mice were randomly placed into different groups based on the tumor volume. Themice were then injected with 3mg/kg ADC's by i.v, BIW, administration. Determined tumor volume after the experiment, measured at day 32.

B-NDG mice were engrafted in the right flank with pancreatic cancer patient-derivedtumor tissue fragments (2 mm x 2 mm x 2 mm). The immunofluorescence staining results showed that TPGB-positive cells and MET-positive cells in the pancreatic tumor fragments were 31.01% and 76.96%, respectively. When the tumors in the mice reached a volume of about 200-300mm³, the mice were randomly placed into different groups based on the tumor volume. Themice were then injected with 6mg/kg ADC's by i.v, QW, administration. Determined tumor volume after the experiment, measured at day 25.