Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0MOPXT)
| ADC Name |
AU2023308528A1 ADC5
|
|||||
|---|---|---|---|---|---|---|
| Synonyms |
AU2023308528A1 ADC5
Click to Show/Hide
|
|||||
| Organization |
PHEON THERAPEUTICS LTD
|
|||||
| Drug Status |
Investigative
|
|||||
| Drug-to-Antibody Ratio |
6.7
|
|||||
| Antibody Name |
Trastuzumab
|
Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (HER2)
|
Antigen Info | ||||
| Payload Name |
4- ((S)-2- ((S)-2-amino-3-methylbutanamido)propanamido)benzyl ((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamate
|
Payload Info | ||||
| Payload Target |
DNA topoisomerase I (TOP1)
|
Target Info | ||||
| Linker Name |
Mal-amido-PEG8-acid
|
Linker Info | ||||
| Conjugate Type |
site 2-formylglycine (fGly)residue random conjugation
|
|||||
| Combination Type |
4- ((2S,5S)-37- (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-2-methyl-4,7,35-trioxo-10,13,16,19,22,25,28,31-octaoxa-3,6,34-triazaheptatriacontanamido)benzyl ((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamate
|
|||||