Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0KWGRK
ADC Name
IMMU-140
Synonyms
IMMU140; IMMU 140
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Organization
Immunomedics, Inc.; Gilead Sciences, Inc.
Drug Status
Investigative
Indication
In total 5 Indication(s)
Acute lymphoblastic leukemia
Clinical candidate
.
Acute myeloid leukaemia
Clinical candidate
.
B-cell lymphoma
Clinical candidate
.
Multiple myeloma
Clinical candidate
.
Non Hodgkin lymphoma
Clinical candidate
.
Drug-to-Antibody Ratio
6.1
Structure
Antibody Name
IMMU-114
  Antibody Info 
Antigen Name
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)
  Antigen Info 
Payload Name
Active metabolite of irinotecan SN38
  Payload Info 
Therapeutic Target
DNA topoisomerase 1 (TOP1)
  Target Info 
Linker Name
CL2A
  Linker Info 
Conjugate Type
Inter-chain cysteine.
Combination Type
Govitecan