Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0KNJWR
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| ADC Name |
H1D8-DC
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| Synonyms |
H1D8-DC
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| Organization |
Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, PR China.
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| Drug Status |
Investigative
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| Structure |
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| Antibody Name |
H1D8
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Antibody Info | ||||
| Antigen Name |
CD44 antigen (CD44)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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General Information of The ADMET Data Related to This ADC(2027 Update)
Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Elimination Half-Life (t1/2) | 4 | day |
Briefly, for serum pharmacokinetics, H1D8-DC and its parental mAb, H1D8, were intravenously injected into nude mice. Serum was collected at the indicated times, and the antibody concentrations were evaluated by ELISA. Pharmacokinetic studies demonstrated that drug conjugation had little effect on H1D8 exposure time, and the half-life (T1/2) of H1D8-DC was nearly 4 days.
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References