Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ICCWP
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| ADC Name |
Elatatug vedotin
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| Synonyms |
TORL-2-307; TORL-2-307-ADC; CLDN18.2-307-ADC
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| Organization |
TORL Biotherapeutics (Originator);University of California, Los Angeles
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| Drug Status |
Phase 1 (discontinued)
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| Drug-to-Antibody Ratio |
4
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| Antibody Name |
Anti-CLDN18.2 antibody
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Antibody Info | ||||
| Antigen Name |
Claudin-18.2 (CLDN18.2)
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Antigen Info | ||||
| Payload Name |
MMAE
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
A cleavable linker
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Linker Info | ||||
| Conjugate Type |
Undisclosed
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Gastric cancer |
1 Trials
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| Gastroesophageal junction adenocarcinoma |
1 Trials
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| Pancreatic cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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General Information of The Activity Data Related to This ADC
Identified from the Human Clinical Data
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT05156866 | Clinical Status | Phase 1 | ||
| Clinical Description | A phase 1, first in human, dose-escalation study of TORL-2-307-ADC in participants with advanced cancer. | ||||
| Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
| Patients Enrolled |
Eligible patients had advanced solid tumors (RECIST v1.1 measurable), ECOG 0-1, and adequate organ function. Exclusions included: unresolved toxicities (>Grade 1); recent anticancer therapy (14 days small molecule/28 days biologic); active brain metastases; uncontrolled comorbidities; cardiac disease; MDS/AML history; secondary malignancies (except curatively treated skin/DClS/low-risk prostate cancer); pregnancy/breastfeeding.
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| Administration Dosage |
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| Related Clinical Trial | |||||
| NCT Number | NCT05156866 | Clinical Status | PHASE1 | ||
| Clinical Description | A Phase 1, First in Human, Dose-Escalation Study of TORL-2-307-ADC in Participants With Advanced Cancer | ||||
| Primary Endpoint |
Safety assessments included AE/SAE incidence (NCI-CTCAE v5.0 graded) over 2 years, with MTD determined as the highest dose causing <33% DLTs among 6 evaluable participants in cycle 1 (28 days). RP2D derived from MTD, safety, and PK data.
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| Other Endpoint |
Efficacy measures (ORR/DOR/PFS/TTR) followed RECIST 1.1 over 2 years, with 1-/2-year OS rates tracked. PK profiles (Cmax/Cmin/Tmax/t1/2/AUC/Vz/CL/Rac) for TORL-2-307-ADC were analyzed at steady state (63 days) and single-dose (21 days). ADA positivity was monitored.
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References