Antigen Information

General Information of This Antigen
Antigen ID
TAR0IBZAS
Antigen Name
Claudin-18.2 (CLDN18.2)
Gene Name
CLDN18.2
Gene ID
51208
Sequence
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF
TECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT
SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV
AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI
YDGGARTEDEVQSYPSKHDYV

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Family
CD99 family
Function
Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling. Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency. Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways.

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Uniprot Entry
CLD18_HUMAN
HGNC ID
HGNC:2039
KEGG ID
hsa:51208
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Name Payload Target Linker ADC Info
BL-M05D1
Ed-04
DNA topoisomerase 1 (TOP1)
Gly-Mal-Gly-Gly-Phe-Gly
 ADC Info 
Anti-CLDN18.2 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DA-3501
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Elatatug vedotin [1]
Monomethyl auristatin E
Microtubule (MT)
A cleavable linker
 ADC Info 
BDC-4182
Undisclosed
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
A non-cleavable linker
 ADC Info 
XNW27011
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
SO-N102
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Pentaglycine-EDA uncleavable linker
 ADC Info 
ATG-022
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
PR301
Duostatin 5
Microtubule (MT)
A cleavable linker
 ADC Info 
SKB315
Belotecan-derivative
DNA topoisomerase 1 (TOP1)
Kthiol (pyrimidine-thiol) oligopeptide linker
 ADC Info 
SIBP-A18
DXd
DNA topoisomerase 1 (TOP1)
Mc-VASGFG
 ADC Info 
AZD4360
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-CLDN18.2 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TQB2103
2-DDDX-d
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-CLDN18.2 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Arcotatug tavatecan
Exatecan
DNA topoisomerase 1 (TOP1)
Synaffix linker
 ADC Info 
JS107
Monomethyl auristatin E
Microtubule (MT)
Maleimide linker of vc PAB
 ADC Info 
CN107667118A ADC-1 [2]
CN107667118A ADC-1 linker payload
Undisclosed
CN107667118A ADC-1 linker
 ADC Info 
CN107667118A ADC-2 [2]
CN107667118A ADC-2 linker payload
Undisclosed
CN107667118A ADC-2 linker
 ADC Info 
Anti-CLDN18.2 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYSA1801
Monomethyl auristatin E
Microtubule (MT)
PEG3-Val-Cit-PABC
 ADC Info 
Ciletatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ciletatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CM311-18A9-VH7/VL2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CM311-18A9-VH7/VL2-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CM311-18D10-VH3/VL2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CM311-18D10-VH3/VL2-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CM311-18D10-VH6/VL1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CM311-18D10-VH6/VL1-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CM311-18D10-VH6/VL2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CM311-18D10-VH6/VL2-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Garetatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Garetatug rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2021115426A1 ADC-2 [4]
WO2021115426A1 ADC-2 payload
Undisclosed
WO2021115426A1 ADC-2 linker
 ADC Info 
WO2021115426A1 ADC-3 [4]
WO2021115426A1 ADC-3 payload
Undisclosed
WO2021115426A1 ADC-3 linker
 ADC Info 
WO2021115426A1 ADC-4 [4]
WO2021115426A1 ADC-4 payload
Undisclosed
WO2021115426A1 ADC-4 linker
 ADC Info 
WO2021115426A1 ADC-5 [4]
WO2021115426A1 ADC-5 payload
Undisclosed
WO2021115426A1 ADC-5 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2021115426A1 ADC-1 [4]
WO2021115426A1 ADC-1 payload
Undisclosed
WO2021115426A1 ADC-1 linker
 ADC Info 
WO2021115426A1 ADC-6 [4]
WO2021115426A1 ADC-6 payload
Undisclosed
WO2021115426A1 ADC-6 linker
 ADC Info 
WO2021115426A1 ADC-7 [4]
WO2021115426A1 ADC-7 payload
Undisclosed
WO2021115426A1 ADC-7 linker
 ADC Info 
WO2021115426A1 ADC-8 [4]
WO2021115426A1 ADC-8 payload
Undisclosed
WO2021115426A1 ADC-8 linker
 ADC Info 
WO2021115426A1 ADC-9 [4]
WO2021115426A1 ADC-9 payload
Undisclosed
WO2021115426A1 ADC-9 linker
 ADC Info 
H239H-2b-K-6a-1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN115429893A ADC8 [5]
CN115429893A ADC3 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
CN115429893A ADC9 [5]
CN115429893A ADC3 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
CN115429893A ADC10 [5]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
CN115429893A ADC11 [5]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
CN115429893A ADC12 [5]
CN115429893A ADC2 Payload
Undisclosed
CB07 linker
 ADC Info 
H239H-2b-K-6a-2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN115429893A ADC13 [5]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
CN115429893A ADC14 [5]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1a-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1b-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1c-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1d-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1e-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1f-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1g-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1h-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1i-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
hCL1j-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HClaudin18.2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LCB02A
PR301839
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
IMAB362-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
IMAB362-MC-Val-Cit-PAB-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
IMAB362-LC-G2-PNU [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IMAB362-DM4
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IMAB362-vCMMAE
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
RGCLN18.2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RGCLN18.2-MC-Val-Cit-PAB-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
RGCLN18.2-D07-Val-Cit-PAB-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
D07-Val-Cit-PABC
 ADC Info 
RGCLN18.2-PY-Val-Cit-PAB-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
PY-VC-PABC
 ADC Info 
Sonesitatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Sonesitatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
SYM003 (anti-Claudin 18.2)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024169913A1 ADC03-01-8 [9]
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
(Linker-03)SMCC-TAZ-PEG-VC-PAB
 ADC Info 
WO2024169913A1 ADC03-01-4 [9]
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
 ADC Info 
Tecotabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tecotabart vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Zolbetuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN118873678A ADC-17 [10]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN118873678A ADC-18 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LNL-008 [11]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
BSI-706 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
BSI-077 [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MIL-106 [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Alpha-CLDN-VC0101 [15]
Auristatin 0101
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CPO-102 [16]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
alphaCLDN18.2-MMAE [17]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody-Drug Conjugate for Treatment of CLDN18.2-Positive Cancers
Ref 2 Drug conjugates comprising antibodies against claudin 18.2.
Ref 3 Antibody-drug conjugate and application thereof
Ref 4 Anti-claudin antibody-drug conjugate and pharmaceutical use thereof; 2021-06-17.
Ref 5 Drug conjugates and uses thereof
Ref 6 Tumor-specific claudin 18.2 antibody-drug complex
Ref 7 Introduction to basic information on ADC drug IMAB362-VCMMAE.
Ref 8 Anti-claudin 18.2 antibody and antibody-drug conjugate thereof; 2022-11-17.
Ref 9 Domide molecular glue derivative and use thereof
Ref 10 Antibody-drug conjugates and uses thereof
Ref 11 Introduction to basic information on ADC drug LNL-008.
Ref 12 Introduction to basic information on ADC drug BSI-706.
Ref 13 Introduction to basic information on ADC drug BSI-077.
Ref 14 Introduction to basic information on ADC drug MIL-106.
Ref 15 Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer. Sci Rep. 2019 Jun 10;9(1):8420. doi: 10.1038/s41598-019-44874-0.
Ref 16 Conjupro biotherapeutics product pipeline
Ref 17 Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer