General Information of This Antibody-drug Conjugate (ID: DRG0GQWJI)
ADC Name
M7437
Synonyms
M7437
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Organization
Merck KGaA (Top20 MNC) (Originator)
Drug Status
Phase 1
Antibody Name
Anti-Ly6E antibody
 Antibody Info 
Antigen Name
Lymphocyte antigen 6E (LY6E)
 Antigen Info 
Payload Name
Exatecan
 Payload Info 
Payload Target
DNA topoisomerase 1 (TOP1)
 Target Info 
Linker Name
Undisclosed
Conjugate Type
Undisclosed
2027 Update
The disease landscape of This ADC
2027 Update
The clinical trial pipelines of This ADC
Indication Phase 1 Phase 2 Phase 3 Approved
Unspecific solid tumor
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00
Gastric cancer
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00
Pancreatic cancer
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00
Lung cancer
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00
Breast cancer
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00
Ovarian cancer
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00
Head and neck cancer
1 Trials
Trial ID
NCT07360314; NCT07311603; jRCT2031250678; EudraCT2025-523232-39; EUCT2025-523232-39-00